The effects of 3,5,5-trimethylcyclohexanol on hepatic cholesterol synthesis, bile flow and biliary lipid secretion in the rat.

abstract：:Cellular electrophysiological effects of membrane lipid peroxidation by t-butyl hydroperoxide (TBH) were studied in the rabbit sinoatrial (SA) node. Superfusion for 1-5 min with 300 microM TBH caused an initial increase and subsequent decrease in the spontaneous firing frequency of the SA node. Voltage clamp experimen...

journal_title：British journal of pharmacology

authors： Sato N,Nishimura M,Tanaka H,Homma N,Watanabe Y

更新日期：1989-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Substance P (SP) and calcitonin gene-related peptide (CGRP) released from capsaicin-sensitive sensory nerves induce local neurogenic inflammation; somatostatin exerts systemic anti-inflammatory actions presumably via sst4/sst1 receptors. This study investigates the effects of a high affinity, sst...

journal_title：British journal of pharmacology

authors： Helyes Z,Pintér E,Németh J,Sándor K,Elekes K,Szabó A,Pozsgai G,Keszthelyi D,Kereskai L,Engström M,Wurster S,Szolcsányi J

更新日期：2006-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Partial agonists selective for α4β2 nicotinic ACh receptors have been developed for smoking cessation as they induce weak activation of native α4β2* receptors and inhibit effect of nicotine. However, it is unclear whether at brain functions there is an existence of receptor reserve that allows we...

journal_title：British journal of pharmacology

authors： Chen Y,Broad LM,Phillips KG,Zwart R

更新日期：2012-02-01 00:00:00

abstract：:Ischaemia is amongst the leading causes of death. Despite this importance, there are only a few therapeutic approaches to protect from ischaemia-reperfusion injury (IRI). In experimental studies, the amino acid glycine effectively protected from IRI. In the prevention of IRI by glycine in cells and isolated perfused o...

journal_title：British journal of pharmacology

authors： Petrat F,Boengler K,Schulz R,de Groot H

更新日期：2012-04-01 00:00:00

abstract：:The concentration in rat striatum of the meta and para isomers of tyramine and alpha-methyltyramine, after the administration of (+)-amphetamine, alpha-methyl-p-tyrosine (AMPT) and alpha-methylphenylalanine (AMPA) has been determined using chemical ionization gas chromatography mass spectrometry (c.i.g.c.m.s.). Twenty...

journal_title：British journal of pharmacology

authors： Dougan DF,Duffield AM,Duffield PH,Wade DN

更新日期：1983-10-01 00:00:00

abstract：:1. Adenosine 5'-triphosphate (ATP) is known to augment cardiac contractile activity and cause an increase in intracellular Ca(2+) concentration ([Ca(2+)](i)) in isolated cardiomyocytes. However, no information regarding the ATP-mediated signal transduction in the myocardium in congestive heart failure (CHF) is availab...

journal_title：British journal of pharmacology

authors： Saini HK,Shao Q,Musat S,Takeda N,Tappia PS,Dhalla NS

更新日期：2005-01-01 00:00:00

abstract：:1. The distribution of sympathetic adrenergic nerves on the rat middle cerebral artery and on the arterioles which originated from it was determined by use of gloxylic histochemistry. 2. Whereas the middle cerebral artery and proximal arterioles arising from this artery received a sympathetic innervation, the distal r...

journal_title：British journal of pharmacology

authors： Edwards FR,Hards D,Hirst GD,Silverberg GD

更新日期：1989-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The histamine H4 receptor is widely expressed in cells of immune origin and has been shown to play a role in a variety of inflammatory processes mediated by histamine. In this report, we describe the in vitro and in vivo anti-inflammatory properties of a potent histamine H4 receptor antagonist, A...

journal_title：British journal of pharmacology

authors： Strakhova MI,Cuff CA,Manelli AM,Carr TL,Witte DG,Baranowski JL,Vortherms TA,Miller TR,Rundell L,McPherson MJ,Adair RM,Brito AA,Bettencourt BM,Yao BB,Wetter JM,Marsh KC,Liu H,Cowart MD,Brioni JD,Esbenshade TA

更新日期：2009-05-01 00:00:00

abstract：:Asthma is an inflammatory disease of the lungs and the transcription factor NF-kappa B regulates the production of numerous inflammatory mediators that may have a role in the pathogenesis of asthma. Hence, the signalling pathways leading to NF-kappa B activation are considered prime targets for novel anti-inflammatory...

journal_title：British journal of pharmacology

authors： Catley MC,Chivers JE,Holden NS,Barnes PJ,Newton R

更新日期：2005-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The renal sodium-glucose cotransporter 2 (SGLT2) plays an important role in the reuptake of filtered glucose in the proximal tubule and therefore may be an attractive target for the treatment of diabetes mellitus. This study characterizes the pharmacological profile of TS-071 ((1S)-1,5-anhydro-1-...

journal_title：British journal of pharmacology

authors： Yamamoto K,Uchida S,Kitano K,Fukuhara N,Okumura-Kitajima L,Gunji E,Kozakai A,Tomoike H,Kojima N,Asami J,Toyoda H,Arai M,Takahashi T,Takahashi K

更新日期：2011-09-01 00:00:00

abstract：:1 Endothelin-1 (ET-1), an endothelium-derived vasoactive peptide, participates in the regulation of endothelial function through mechanisms that are not fully elucidated. This study examined the impact of ET-1 on oxidative stress, apoptosis and cell proliferation in human umbilical vein endothelial cells (HUVEC). HUVE...

journal_title：British journal of pharmacology

authors： Dong F,Zhang X,Wold LE,Ren Q,Zhang Z,Ren J

更新日期：2005-06-01 00:00:00

abstract：:Cyclic adenosine monophosphate (cAMP) is one of the second messengers critically involved in the molecular mechanisms underlying memory formation. In the CNS, the availability of cAMP is tightly controlled by phosphodiesterase 4 (PDE4), a family of enzymes that degrades the cyclic nucleotide to inactive AMP. Among the...

journal_title：British journal of pharmacology

authors： Ricciarelli R,Fedele E

更新日期：2015-10-01 00:00:00

abstract：:The above article, published by the British Journal of Pharmacology in October 2015 (https://bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bph.13259), has been retracted by agreement between the authors, the journal Editor in Chief and John Wiley & Sons Limited. The retraction has been agreed owing to the discovery...

journal_title：British journal of pharmacology

authors：

更新日期：2018-07-01 00:00:00

abstract：:1. A study was made to exclude the notion that adenosine receptor agonists exert a direct physical blockade of the depolarization-secretion process. Reduced temperature was employed as a tool for distinguishing between physico-chemical processes (such as those which mediate evoked transmitter release) and biochemical ...

journal_title：British journal of pharmacology

authors： Silinsky EM,Hirsh JK

更新日期：1988-04-01 00:00:00

abstract：:1. In pithed rats, preganglionic vagal nerve stimulation (at 5 Hz) elicited a bradycardia. This bradycardia was potentiated by the angiotensin converting enzyme inhibitor, captopril (1 mg kg-1, i.v.) by about 40%. Subsequent angiotensin II infusion (0.03 micrograms kg-1 min-1) reversed this effect. A similar facilitat...

journal_title：British journal of pharmacology

authors： Rechtman M,Majewski H

更新日期：1993-09-01 00:00:00

abstract：:1. We compared the relaxant effect of pituitary adenylate cyclase activating peptide (PACAP) 1-27 with that of a newly developed PACAP 1-27 analogue, [Arg15,20,21Leu17]-PACAP-Gly-Lys-Arg-NH2, in the guinea-pig trachea and primate bronchi in vitro (n = 4-5). 2. In the guinea-pig trachea precontracted by a submaximally ...

journal_title：British journal of pharmacology

authors： Yoshihara S,Lindén A,Kashimoto K,Nagano Y,Ichimura T,Nadel JA

更新日期：1997-08-01 00:00:00

abstract：:1. To see if arachidonic acid (AA) plays a role in the sustained suppression of voltage-gated calcium channel currents produced by muscarinic receptor stimulation by carbachol (CCh), the effects of AA on membrane currents were examined in whole-cell voltage-clamped smooth muscle cells of the guinea-pig ileum. 2. In ce...

journal_title：British journal of pharmacology

authors： Unno T,Komori S,Ohashi H

更新日期：1996-09-01 00:00:00

abstract：:1. The effect of histamine H1-receptor stimulation on inositol phospholipid hydrolysis has been investigated in the hamster vas deferens smooth muscle cell line, DDT1MF-2. 2. Histamine (EC50 = 27 microM) stimulated the accumulation of [3H]-inositol phosphates in DDT1MF-2 cells prelabelled with [3H]-myo-inositol. 2-Thi...

journal_title：British journal of pharmacology

authors： White TE,Dickenson JM,Hill SJ

更新日期：1993-01-01 00:00:00

abstract：:Histamine has been one of the most studied substances in medicine, playing a major role in diverse (patho)physiological processes. It elicits its multifaceted modulatory functions by activating four types of GPCRs, designated as H1-4 . Despite the heterogeneity and the complexity of histamine receptor pharmacology, ma...

journal_title：British journal of pharmacology

authors： Tiligada E,Ennis M

更新日期：2020-02-01 00:00:00

abstract：:1. The role of alpha2-adrenoceptor (AR) subtypes in the modulation of acute nociception, motor behaviour and body temperature, has been investigated by determining the activity of the alpha2AR selective agonist dexmedetomidine (Dex) in mice devoid of individual alpha2AR subtypes through either a point (alpha2A) or nul...

journal_title：British journal of pharmacology

authors： Hunter JC,Fontana DJ,Hedley LR,Jasper JR,Lewis R,Link RE,Secchi R,Sutton J,Eglen RM

更新日期：1997-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Hydrogen sulphide reduces uterine contractility and is of potential interest as a treatment for uterine disorders. The aim of this study was to explore the mechanism of sodium sulphide (Na2 S)-induced relaxation of rat uterus, investigate the importance of redox effects and ion channel-mediated m...

journal_title：British journal of pharmacology

authors： Mijušković A,Kokić AN,Dušić ZO,Slavić M,Spasić MB,Blagojević D

更新日期：2015-07-01 00:00:00

abstract：:1. The measurement of changes in spike generation and membrane resistance in the guinea-pig taenia coli, using the sucrose gap extracellular recording method, has been shown to be a useful way to demonstrate the intrinsic sympathomimetic activity of the beta adrenoceptor blocking agents.2. Pronethalol, INPEA, MJ 1999,...

journal_title：British journal of pharmacology

authors： Davis WG

更新日期：1970-01-01 00:00:00

abstract：:The kallikrein-kinin system is subdivided into the plasma and tissue-kallikrein-kinin system, with bradykinin (BK) and kallidin (KAL) (Lys(0)-bradykinin) as functional peptides. This occurs in both humans and other mammals. Both peptides are released by plasma and tissue-kallikrein. BK, but not KAL, has been detected ...

journal_title：British journal of pharmacology

authors： Hilgenfeldt U,Stannek C,Lukasova M,Schnölzer M,Lewicka S

更新日期：2005-12-01 00:00:00

abstract：:1. In order to explore whether 5-HT4 receptor subtypes exist, we have characterized further the 5-HT4 receptor that mediates tachycardia in the piglet isolated right atrium. All experiments were carried out in the presence of propranolol (400 nM) and cocaine (6 microM). We used tryptamine derivatives, substituted benz...

journal_title：British journal of pharmacology

authors： Medhurst AD,Kaumann AJ

更新日期：1993-11-01 00:00:00

abstract：:In vitro preparations of rabbit heart were made from which measurements of effective refractory period (ERP), atrio-Hisian (A-H) and His-Purkinje (H-P) conduction times could be obtained, analogous to electrophysiological measurements customarily carried out in vivo. Intracellular potentials also were recorded from th...

journal_title：British journal of pharmacology

authors： Millar JS,Vaughan Williams EM

更新日期：1983-07-01 00:00:00

abstract：:Muscularis mucosa of the distal oesophagus of the opossum contains nerves which release acetylcholine and substance P(SP)-like material on field stimulation. The release of SP-like material appeared to be inhibited by the presence of exogenous muscarinic agonists and potentiated by muscarinic antagonists. Analysis of ...

journal_title：British journal of pharmacology

authors： Daniel EE,Jury J,Robotham KH

更新日期：1986-07-01 00:00:00

abstract：:1. The effect of basal tension (transmural tensions 235 +/- 29 mg wt (low tension: equivalent to approximately 16 mmHg) and 305 +/- 34 mg wt (high tension: equivalent to 35 mmHg)) on rat pulmonary resistance artery responses to endothelin-1 (ET-1) and the selective ET(B)-receptor agonist sarafotoxin S6c (S6c) were stu...

journal_title：British journal of pharmacology

authors： MacLean MR,McCulloch KM

更新日期：1998-03-01 00:00:00

abstract：:1. Both in mammalian tissues and in transfected cells, only low levels of alpha1D-adrenoceptors are detected in radioligand binding studies. It has been implicated that the comparatively long N-terminal tail of the alpha1D-adrenoceptor is responsible for the inefficient surface expression of the receptor. 2. In the pr...

journal_title：British journal of pharmacology

authors： Petrovska R,Kapa I,Klovins J,Schiöth HB,Uhlén S

更新日期：2005-03-01 00:00:00

abstract：:The role of extracellular signal-regulated kinase (ERK)-1 and ERK-2 in controlling histamine-induced tone in bovine trachealis was investigated. PD 098059, an inhibitor of mitogen-activated protein kinase kinase (MKK)-1, had no effect on the histamine concentration-response relationship that described contraction. How...

journal_title：British journal of pharmacology

authors： Koch A,Nasuhara Y,Barnes PJ,Lindsay MA,Giembycz MA

更新日期：2000-11-01 00:00:00

abstract：:1. Diabetic modifications of nicotinic receptor-operated noncontractile Ca2- mobilization observed in the presence of anticholinesterase were investigated by measuring Ca(2+)-aequorin luminescence in diaphragm muscles of mice with diabetes induced by injections of streptozotocin (150 mg kg-1, bolus i.v.) and alloxan (...

journal_title：British journal of pharmacology

authors： Kimura I,Tsuneki H,Dezaki K,Kimura M

更新日期：1995-11-01 00:00:00