Abstract：
:1. Immunohistochemical and functional studies have been performed to localize and determine the effects of neuropeptide Y (NPY) in the rat seminal vesicle. 2. An abundant presence of NPY-immunoreactive nerves, mainly concentrated in the smooth muscle layer of the seminal vesicle was found. Chronic 6-hydroxydopamine treatment (four doses of 50 mg kg-1 i.p. on days 1, 2, 4 and 6; rats killed one week after the last injection) led to a large reduction but not abolition of the NPY-immunoreactivity. 3. NPY (1-250 nM) did not affect the resting tone of the seminal vesicle. 4. The seminal vesicle was contracted by electrical field stimulation (EFS) and by exposure to 5 microM noradrenaline (NA). These contractions were abolished by phentolamine (1 microM). Tetrodotoxin (0.5 microM) abolished EFS-evoked contractions but did not affect NA-evoked contractions. 5. Seminal vesicles, from animals chronically-treated with reserpine (5 mg kg-1 i.p. on days 1 and 2; rats killed on day 3), were contracted by NA but not by EFS. 6. NPY (0.25-250 nM), concentration-dependently, inhibited EFS-evoked contractions by up to 70% maximum inhibition. Contractions evoked by EFS with short trains of pulses were inhibited by NPY to a greater degree than those with longer trains. 7. NPY had no significant effect on NA-evoked contractions. 8. These data provide strong evidence that the motor transmission in rat seminal vesicle is predominantly if not exclusively, adrenergic. It is further concluded that a rich NPY-containing innervation is present in the smooth muscle layer of rat seminal vesicle. The primary effect of NPY is modulation of adrenergic motor transmission by a prejunctional inhibition of NA release.
journal_name
Br J Pharmacoljournal_title
British journal of pharmacologyauthors
Iravani MM,Zar MAdoi
10.1111/j.1476-5381.1994.tb17074.xsubject
Has Abstractpub_date
1994-11-01 00:00:00pages
877-82issue
3eissn
0007-1188issn
1476-5381journal_volume
113pub_type
杂志文章abstract：:1 The butyrophenone tranquilizer, azaperone, was administered intramuscularly, at dose levels of 0.4 and 0.8 mg/kg, to ponies and its effects on cardiovascular and respiratory functions assessed. 2 Arterial blood pH, CO2 tension (PaCO2) and O2 tension (PaO2) remained relatively constant throughout the course of action...
journal_title：British journal of pharmacology
pub_type： 杂志文章
doi：10.1111/j.1476-5381.1976.tb07637.x
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journal_title：British journal of pharmacology
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doi：10.1111/j.1476-5381.1987.tb08961.x
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pub_type： 杂志文章
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更新日期：1982-08-01 00:00:00
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pub_type： 评论,杂志文章
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pub_type： 杂志文章
doi：10.1111/j.1476-5381.1976.tb07700.x
更新日期：1976-09-01 00:00:00
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更新日期：2007-03-01 00:00:00
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journal_title：British journal of pharmacology
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doi：10.1111/j.1476-5381.1996.tb16690.x
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journal_title：British journal of pharmacology
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doi：10.1111/j.1476-5381.1977.tb07518.x
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doi：10.1111/bph.12784
更新日期：2014-09-01 00:00:00
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journal_title：British journal of pharmacology
pub_type： 杂志文章
doi：10.1111/bph.15382
更新日期：2021-01-21 00:00:00
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journal_title：British journal of pharmacology
pub_type： 杂志文章
doi：10.1111/j.1476-5381.1983.tb10031.x
更新日期：1983-10-01 00:00:00
