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Control of adenosine-3',5'-monophosphate level in human amnion by prostaglandin E1 and isoproterenol.

Abstract：

:The adenosine-3',5'-monophosphate (cAMP) level in human amnion has been measured in vitro during short-term incubations, with or without prostaglandin E1 (PGE1) or isoproterenol. Concentration-response and kinetic curves were obtained. Isoproterenol and PGE1 stimulated cAMP production by amnion in a time-dependent manner. The stimulating effect of isoproterenol and noradrenalin on cAMP level was abolished by the addition of propranolol. Our study, demonstrating cAMP production by amniotic membranes and its stimulation by PGE1 and beta-agonists, suggests that hormones could modulate the amniotic cell metabolism through the cAMP system.

journal_name

Am J Obstet Gynecol

journal_title

American journal of obstetrics and gynecology

authors

Kirkpatrick C,Bogaert C,Vansande J,Rodesch F

doi

10.1016/s0002-9378(16)32592-3

subject

Has Abstract

pub_date

1981-09-15 00:00:00

pages

195-8

issue

2

eissn

0002-9378

issn

1097-6868

pii

S0002-9378(16)32592-3

journal_volume

141

pub_type

杂志文章

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