Perceived risk of prenatal diagnostic procedure-related miscarriage and Down syndrome among pregnant women.

Abstract:

OBJECTIVE:The objective of the study was to identify correlates of perceived risk of carrying a Down syndrome-affected fetus or experiencing a procedure-related miscarriage among a diverse group of pregnant women. STUDY DESIGN:We conducted a cross-sectional survey of 1081 English-, Spanish-, or Chinese-speaking women receiving prenatal care in the San Francisco Bay area. Perceived risk of procedure-related miscarriage or carrying a Down syndrome-affected fetus was assessed using a linear rating scale from 0 (no risk) to 1 (high risk). Bivariate and multivariable analyses were used to explore associations between maternal characteristics including age, race/ethnicity, and socioeconomic status and perceived risks of carrying a Down syndrome-affected fetus or experiencing a procedure-related miscarriage. RESULTS:Women aged 35 years old or older had a higher perceived risk of Down syndrome than younger women (0.28 vs 0.22 on a scale from 0 to 1, P < .001) but a lower perceived risk of a procedure-related miscarriage (0.31 vs 0.36, P = .004). In multivariable linear regression analysis among women younger than age 35 years, the perceived risk of carrying a Down syndrome-affected fetus was higher in women who had not attended college (+0.06, P = .019) or had poor self-perceived health status (+0.08, P = .045). Latinas (+0.11, P = .008), women with an annual income less than $35,000 (+0.09, P = .003), and those who had difficulty conceiving (+0.09, P = .026) had higher perceived procedure-related miscarriage risk. Among women aged 35 years or older, perceived risk of carrying a Down syndrome-affected fetus was associated with the inclination to undergo prenatal diagnosis. CONCLUSION:Women's perceived risks of carrying a Down syndrome-affected fetus or having a procedure-related miscarriage are associated with numerous characteristics that have not been shown to be associated with the actual risks of these events. These perceived risks are associated with prenatal diagnostic test inclination. Understanding patients' risk perceptions and effectively communicating risk is critical to helping patients make informed decisions regarding use of invasive prenatal testing.

journal_name

Am J Obstet Gynecol

authors

Caughey AB,Washington AE,Kuppermann M

doi

10.1016/j.ajog.2007.09.045

subject

Has Abstract

pub_date

2008-03-01 00:00:00

pages

333.e1-8

issue

3

eissn

0002-9378

issn

1097-6868

pii

S0002-9378(07)01189-1

journal_volume

198

pub_type

杂志文章
  • Use of cardiac index in pregnancy: is it justified?

    abstract:OBJECTIVE:The aim of this study was to test the hypothesis that standardization of cardiac output in pregnancy by correcting for body surface area, and thus obtaining cardiac index, is justified. STUDY DESIGN:Cardiac output was determined by thoracic electrical bioimpedance monitoring in 78 pregnant women; recordings ...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/0002-9378(95)90367-4

    authors: van Oppen AC,van der Tweel I,Duvekot JJ,Bruinse HW

    更新日期:1995-09-01 00:00:00

  • Trends in demographic and clinical characteristics in women diagnosed with corpus cancer and their potential impact on the increasing number of deaths.

    abstract:OBJECTIVE:The purpose of this study was to determine factors responsible for the increasing number of deaths from corpus cancer over three time periods. STUDY DESIGN:Data were collected from the Surveillance, Epidemiology and End Results database from 1988-2001. Kaplan-Meier and Cox proportional hazards regression ana...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/j.ajog.2007.08.075

    authors: Ueda SM,Kapp DS,Cheung MK,Shin JY,Osann K,Husain A,Teng NN,Berek JS,Chan JK

    更新日期:2008-02-01 00:00:00

  • Quantitative assessment of Langerhans' cells in human cervical intraepithelial neoplasia and wart virus infection.

    abstract::Langerhans' cell density was assessed quantitatively in cervical wart virus infection (cervical condyloma), cervical intraepithelial neoplasia, and koilocytic dysplasia with use of an antibody to S100 protein and an indirect immunoperoxidase technique. When compared with normal ectocervix, Langerhans' cell density was...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/0002-9378(86)90592-2

    authors: McArdle JP,Muller HK

    更新日期:1986-03-01 00:00:00

  • A randomized trial of ofloxacin versus cefoxitin and doxycycline in the outpatient treatment of acute salpingitis.

    abstract::The object of this randomized study was to compare the safety and efficacy of oral ofloxacin, 400 mg twice daily for 10 days, versus intramuscular cefoxitin, 2 gm, plus oral probenecid, 1 gm, followed by oral doxycycline, 100 mg twice daily for 10 days, in the outpatient treatment of uncomplicated acute salpingitis. T...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/0002-9378(91)91479-g

    authors: Wendel GD Jr,Cox SM,Bawdon RE,Theriot SK,Heard MC,Nobles BJ

    更新日期:1991-05-01 00:00:00

  • Postpartum hemorrhage with concurrent massive inferior epigastric artery bleeding after cesarean delivery.

    abstract::Postpartum hemorrhage with concurrent massive inferior epigastric artery bleeding after cesarean delivery is unusual. In the current case, besides embolization of the bilateral hypogastric arteries, recognition and successful embolization of a clinically overlooked active bleeding source in the abdominal wall was cruc...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1067/mob.2002.122417

    authors: Ko SF,Lin H,Ng SH,Lee TY,Wan YL

    更新日期:2002-07-01 00:00:00

  • Buserelin versus danazol in the treatment of endometriosis-associated infertility.

    abstract::A total of 62 infertile women with a laparoscopic diagnosis of endometriosis were allocated randomly to two treatment groups, one of which (32 patients) received oral danazol 600 micrograms/day and the other (30 patients) received intranasal buserelin 1200 micrograms/day for 6 months. Suppression of serum levels of es...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/0002-9378(89)90739-4

    authors: Fedele L,Bianchi S,Arcaini L,Vercellini P,Candiani GB

    更新日期:1989-10-01 00:00:00

  • The effect of in utero exposure to indomethacin on the need for surgical closure of a patent ductus arteriosus in the neonate.

    abstract:OBJECTIVE:Our purpose was to determine the effect of in utero exposure to indomethacin on the need for surgical closure of a patent ductus arteriosus (PDA). STUDY DESIGN:Perinatal variables were compared between infants at <32 weeks who required surgical closure of PDA after failed medical management and those who did...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1067/mob.2002.127464

    authors: Suarez VR,Thompson LL,Jain V,Olson GL,Hankins GD,Belfort MA,Saade GR

    更新日期:2002-10-01 00:00:00

  • Sclerema neonatorum and joint contractures at birth as a potential complication of chronic in utero hypoxia.

    abstract::Three term neonates presented with an unusual combination of skin changes (sclerema) and joint contractures at birth. In each case a prolonged period of fetal hyporeactivity was reported by the mother. Each child demonstrated a number of clinical findings consistent with chronic fetal hypoxia. Each child recovered wit...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/0002-9378(86)90834-3

    authors: Molteni RA,Ames MR

    更新日期:1986-08-01 00:00:00

  • Oxytocin given in a pulsatile manner to the ewe at 120 to 140 days' gestational age increases fetal sheep plasma cortisol.

    abstract::A single intravenous injection of oxytocin into pregnant sheep (123 to 144 days' gestational age) causes a bout of myometrial activity and an increase in fetal plasma corticotropin levels. We hypothesized that a sustained increased frequency of myometrial contractures accelerates the normal increase in fetal adrenal s...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/0002-9378(92)91859-9

    authors: Sadowsky DW,Martel J,Cabalum T,Poore MG,Nathanielsz PW

    更新日期:1992-01-01 00:00:00

  • Measurement of endometrial stripe thickness by obstetrics and gynecology residents.

    abstract:OBJECTIVE:How well do obstetrics and gynecology residents measure the endometrial stripe by transvaginal sonography? STUDY DESIGN:Three obstetrics and gynecology residents at the University of Texas Medical Branch from each year level were tested for their ability to perform endometrial stripe measurements. Measuremen...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/j.ajog.2005.08.030

    authors: Breitkopf DM,Smith ER,Herbert WN

    更新日期:2005-11-01 00:00:00

  • Prediction of safe and successful vaginal twin birth.

    abstract:OBJECTIVE:The objective of the study was to establish predictors of vaginal twin birth and evaluate perinatal morbidity according to mode of delivery. STUDY DESIGN:One thousand twenty-eight twin pregnancies were prospectively recruited. For this prespecified secondary analysis, obstetric characteristics and a composit...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/j.ajog.2011.05.033

    authors: Breathnach FM,McAuliffe FM,Geary M,Daly S,Higgins JR,Dornan J,Morrison JJ,Burke G,Higgins S,Dicker P,Manning F,Carroll S,Malone FD,Perinatal Ireland Research Consortium.

    更新日期:2011-09-01 00:00:00

  • Derivation of new mathematic formulas for determining whether a D-positive father is heterozygous or homozygous for the D antigen.

    abstract:OBJECTIVES:This article derives new mathematic formulas to calculate the probability that the husband of a D-negative woman is heterozygous for the D antigen. STUDY DESIGN:Current published formulas and tables that estimate this probability are biased in that they incorrectly assume that the father is randomly selecte...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/0002-9378(92)91830-4

    authors: Kanter MH

    更新日期:1992-01-01 00:00:00

  • The effect of actinomycin D on estrogen-induced uterine blood flow.

    abstract::The effect of actinomycin D on estrogen-induced uterine blood flow was studied in four nonpregnant, oophorectomized sheep, utilizing electromagnetic flow probes chronically implanted around the uterine arteris. Two hours after the intravenous injection of 1 mug of estradiol-17beta per kilogram of body weight, incorpor...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 历史文章,杂志文章

    doi:10.1016/0002-9378(75)90166-0

    authors: Resnik R,Battaglia FC,Makowski EL,Meschia G

    更新日期:1975-06-01 00:00:00

  • Heart rate and blood pressure variabilities are increased in pregnancy-induced hypertension.

    abstract:OBJECTIVE:Our purpose was to study whether cardiovascular changes in pregnancy-induced hypertension are associated with the increase in sympathetic control of hemodynamics and change in sympathovagal balance. STUDY DESIGN:Fourteen women with pregnancy-induced hypertension and 16 women with uncomplicated pregnancies of...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/s0002-9378(97)70041-3

    authors: Ekholm EM,Tahvanainen KU,Metsälä T

    更新日期:1997-11-01 00:00:00

  • Inferior vena cava compression in the pregnant dog.

    abstract::Attempts were made to produce inferior vena cava (IVC) compression in 14 pregnant and 12 nonpregnant bitches. Ligation of the iliac veins, the IVC below the renal veins, or the left renal vein separately produced minimal hemodynamic disturbances. Only ligation of the two renal veins or of the IVC above the renal veins...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/0002-9378(78)90365-4

    authors: Abitbol MM

    更新日期:1978-01-15 00:00:00

  • The obstetrical and neonatal impact of maternal opioid detoxification in pregnancy.

    abstract:OBJECTIVE:The purpose of this study was to analyze the obstetric and neonatal impact of an opioid detoxification program during pregnancy, as well as to examine variables associated with successful opioid detoxification. STUDY DESIGN:This is a retrospective cohort study of women electing inpatient detoxification and s...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/j.ajog.2013.05.026

    authors: Stewart RD,Nelson DB,Adhikari EH,McIntire DD,Roberts SW,Dashe JS,Sheffield JS

    更新日期:2013-09-01 00:00:00

  • Transvaginal ultrasonographic characterization of ovarian masses by means of color flow-directed Doppler measurements and a morphologic scoring system.

    abstract:OBJECTIVE:The aim of the study was to test the hypothesis that a combination of a previously devised morphologic scoring system and color flow-directed Doppler measurements would afford better discrimination between benign and malignant ovarian masses. STUDY DESIGN:The scoring system and color flow-directed Doppler me...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/s0002-9378(12)90843-1

    authors: Timor-Tritsch LE,Lerner JP,Monteagudo A,Santos R

    更新日期:1993-03-01 00:00:00

  • Pathophysiology of placental-derived fetal growth restriction.

    abstract::Placental-related fetal growth restriction arises primarily due to deficient remodeling of the uterine spiral arteries supplying the placenta during early pregnancy. The resultant malperfusion induces cell stress within the placental tissues, leading to selective suppression of protein synthesis and reduced cell proli...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章,评审

    doi:10.1016/j.ajog.2017.11.577

    authors: Burton GJ,Jauniaux E

    更新日期:2018-02-01 00:00:00

  • Parturitional factors associated with membrane stripping.

    abstract:OBJECTIVE:Our purpose was to determine what factors occurring after digital separation of the chorionic membranes from the lower uterine segment (membrane stripping) are involved in observed clinical changes compared with patients not so treated. STUDY DESIGN:Thirty patients were randomly divided among a study populat...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/0002-9378(93)90134-5

    authors: McColgin SW,Bennett WA,Roach H,Cowan BD,Martin JN Jr,Morrison JC

    更新日期:1993-07-01 00:00:00

  • The fetal central venous pressure waveform in normal pregnancy and in umbilical placental insufficiency.

    abstract:OBJECTIVE:Our purpose was to study the fetal central venous pressure waveform recorded noninvasively from the inferior vena cava in normal and complicated pregnancies by means of newly developed equipment to follow the vessel lumen diameter. STUDY DESIGN:A paired ultrasonic phase-locked loop echo tracking system with ...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/0002-9378(95)90083-7

    authors: Mori A,Trudinger B,Mori R,Reed V,Takeda Y

    更新日期:1995-01-01 00:00:00

  • The effect of the postnatal environment on altered fetal programming of adult vascular function in mice that lack endothelial nitric oxide synthase.

    abstract:OBJECTIVE:The purpose of this study was to investigate vascular reactivity in heterozygous and homozygous offspring with a genetic predisposition for hypertension after postnatal cross-fostering to mothers with the opposite genetic inheritance of the NOS3 knockout allele. STUDY DESIGN:Homozygous NOS3 knockout (C57BL/6...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/j.ajog.2007.01.031

    authors: Clark SM,Makhlouf M,Hankins GD,Anderson GD,Saade GR,Longo M

    更新日期:2007-04-01 00:00:00

  • SMFM Special Report: Putting the "M" back in MFM: Addressing education about disparities in maternal outcomes and care.

    abstract::At the 36th Annual meeting of the Society for Maternal-Fetal Medicine (SMFM), leaders in the field of maternal-fetal medicine (MFM) convened to address maternal outcome and care inequities from 3 perspectives: (1) education, (2) clinical care, and (3) research. Meeting attendees identified knowledge gaps regarding dis...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 共识发展会议,杂志文章

    doi:10.1016/j.ajog.2017.11.592

    authors: Moroz L,Riley LE,D'Alton M,Brown HL,Davis AR,Foley M,Graves CR,Sheffield JS,Zerden ML,Bryant AS

    更新日期:2018-02-01 00:00:00

  • Racial/ethnic differences in perineal, vaginal and cervical lacerations.

    abstract:OBJECTIVE:To determine if variation exists between ethnicities for risk of perineal, vaginal, and cervical laceration at vaginal delivery. STUDY DESIGN:Retrospective cohort study of nulliparous women who underwent vaginal delivery of a vertex presentation. Predictor variable was ethnicity with outcome variables cervic...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/j.ajog.2004.12.007

    authors: Hopkins LM,Caughey AB,Glidden DV,Laros RK Jr

    更新日期:2005-08-01 00:00:00

  • Who returns for postpartum glucose screening following gestational diabetes mellitus?

    abstract:OBJECTIVE:The objective of the study was to determine the prevalence of postpartum impaired glucose regulation (IGR) and factors associated with glucose screening following gestational diabetes mellitus (GDM). STUDY DESIGN:This was a prospective cohort study of 707 women with GDM who delivered at the University Hospit...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/j.ajog.2007.09.015

    authors: Hunt KJ,Conway DL

    更新日期:2008-04-01 00:00:00

  • Puerperal septic pelvic thrombophlebitis: incidence and response to heparin therapy.

    abstract:OBJECTIVE:Before the availability of modern imaging studies the diagnosis of septic pelvic thrombophlebitis causing prolonged puerperal fever was difficult to confirm without surgical exploration. With the use of computed tomography infection-related pelvic phlebitis can now be confirmed, and this study was designed to...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s0002-9378(99)70450-3

    authors: Brown CE,Stettler RW,Twickler D,Cunningham FG

    更新日期:1999-07-01 00:00:00

  • Ceramide lactoside in amniotic fluid: high concentration in chorioamnionitis and in preterm labor.

    abstract::The mechanisms responsible for the onset and progression of preterm labor are poorly understood. In the present study a total of 115 amniotic fluid specimens were analyzed for a lipid that has not previously been detected in amniotic fluid. This glycolipid was identified as ceramide lactoside. It was found in two-dime...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/0002-9378(89)90508-5

    authors: Hallman M,Bry K,Pitkänen O

    更新日期:1989-08-01 00:00:00

  • The changing thermal response to endurance exercise during pregnancy.

    abstract::This study was designed to test the hypothesis that the thermal response to endurance exercise is altered by the thermal adaptations to pregnancy. Accordingly, rectal temperature was monitored in 18 recreational athletes before, during, and after 20 minutes of continuous exercise before conception and every 6 to 8 wee...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/0002-9378(91)90015-j

    authors: Clapp JF 3rd

    更新日期:1991-12-01 00:00:00

  • A comparison of visual analyses of intrapartum fetal heart rate tracings according to the new national institute of child health and human development guidelines with computer analyses by an automated fetal heart rate monitoring system.

    abstract:OBJECTIVES:The aim of this study was to compare the visual analyses of fetal heart rate tracings by observers according to recent National Institute of Child Health and Human Development interpretative guidelines both with each other and with those of a computerized fetal heart rate analysis and alerting system. STUDY...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1067/mob.2000.107665

    authors: Devoe L,Golde S,Kilman Y,Morton D,Shea K,Waller J

    更新日期:2000-08-01 00:00:00

  • Comparative study of MMP-2 (matrix metalloproteinase 2) immune expression in normal uterine cervix, intraepithelial neoplasias, and squamous cells cervical carcinoma.

    abstract:OBJECTIVE:This study was undertaken to evaluate the levels of matrix metalloproteinase 2 (MMP-2) in the precursors lesions and in the invasive cervical carcinoma and to quantify the immune reactive expression of MMP-2, using MMP-2 immunohistochemistry, in intraepithelial cervical neoplasias and in the invading cervical...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/j.ajog.2003.12.017

    authors: Gaiotto MA,Focchi J,Ribalta JL,Stávale JN,Baracat EC,Lima GR,Guerreiro da Silva ID

    更新日期:2004-05-01 00:00:00

  • The risk of large for gestational age across increasing categories of pregnancy glycemia.

    abstract:OBJECTIVE:We sought to estimate the risk of large for gestational age (LGA) across categories of glucose tolerance. STUDY DESIGN:In a cohort of 89,141 participants, women without gestational diabetes mellitus (GDM) were categorized by their screening and diagnostic test results; those with GDM were categorized as meet...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/j.ajog.2010.10.907

    authors: Ehrlich SF,Crites YM,Hedderson MM,Darbinian JA,Ferrara A

    更新日期:2011-03-01 00:00:00