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Derivation of new mathematic formulas for determining whether a D-positive father is heterozygous or homozygous for the D antigen.

Abstract：

OBJECTIVES:This article derives new mathematic formulas to calculate the probability that the husband of a D-negative woman is heterozygous for the D antigen. STUDY DESIGN:Current published formulas and tables that estimate this probability are biased in that they incorrectly assume that the father is randomly selected from the general population. With Bayes' theorem, new formulas were derived to eliminate this bias. RESULTS:The probability of the husband being homozygous or heterozygous for the D antigen can be expressed as a function of the number of previous D-positive children. If he has any D-negative children, he is an obligate heterozygote. CONCLUSION:Previously published formulas and tables that estimate the likelihood of the father being heterozygous or homozygous at the D locus should no longer be used in the obstetric setting.

journal_name

Am J Obstet Gynecol

journal_title

American journal of obstetrics and gynecology

authors

Kanter MH

doi

10.1016/0002-9378(92)91830-4

subject

Has Abstract

pub_date

1992-01-01 00:00:00

pages

61-3

issue

1 Pt 1

eissn

0002-9378

issn

1097-6868

pii

0002-9378(92)91830-4

journal_volume

166

pub_type

杂志文章

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