Abstract:
:Starzak and Starzak (1978. IEEE Trans. Biomed. Eng. 25:201-204.) proposed that, in cyclic application of current and voltage-clamps, the fidelity of the match of the output current with the original stimulus could be used to measure the spatial uniformity of voltage in a membrane. However, they failed to find such a match in experiments on either squid axons or an electronic model of a membrane patch. Computer simulations of such experiments show that the failure to return the initial pattern may arise from shortcomings of the instruments or instability of membrane characteristics. Logical arguments show that such cyclic experiments are not able to provide information about spatial gradients of membrane voltage.
journal_name
Biophys Jjournal_title
Biophysical journalauthors
Moore JW,Stockbridge N,Schiff SJdoi
10.1016/S0006-3495(82)84482-2subject
Has Abstractpub_date
1982-12-01 00:00:00pages
259-62issue
3eissn
0006-3495issn
1542-0086pii
S0006-3495(82)84482-2journal_volume
40pub_type
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