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Mechanisms by which proteolytic enzymes prolong the golden period of antibiotic action.

Abstract：

:These experimental studies provide an explanation for the therapeutic value of proteolytic enzymes as adjuncts to antibiotic treatment of contaminated wounds. After wounding, a fibrinous coagulum develops on the wound surface. This coagulum surrounds the bacteria and protects them from contact with sustemically or topically administered antibiotics. Treatment of the wound surface with proteolytic enzymes disrupts the coagulum and exposes the bacteria to the action of the antibiotic. The topical use of enzymes is also associated with significant increases in the concentration of antibiotic at the wound and thus a decrease in the rate of infection.

journal_name

Am J Surg

journal_title

American journal of surgery

authors

Rodeheaver GT,Rye DG,Rust R,Marsh D,Edgerton MT,Edlich RF

doi

10.1016/0002-9610(78)90299-4

subject

Has Abstract

pub_date

1978-09-01 00:00:00

pages

379-82

issue

3

eissn

0002-9610

issn

1879-1883

pii

0002-9610(78)90299-4

journal_volume

136

pub_type

杂志文章

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