Possible mechanism of the synergistic effect of heparin and dihydroergotamine.

Abstract:

:A combination of heparin and dihydroergotamine mesylate (Heparin-Dihydergot) has been shown to be more effective than either of these drugs alone in preventing postoperative venous thromboembolism. The possible mechanism for the synergistic effect of heparin and dihydroergotamine was assessed. Phlebograms obtained after administration of 0.5 mg of dihydroergotamine showed marked constriction of the tibial and soleal veins with a significant reduction in the mean diameter of the femoral vein. The effect on the coagulation mechanism was assessed in 28 patients. Blood samples were withdrawn from the femoral vein during varicose vein operations. A significant difference was observed in antithrombin III activity, kaolin-cephalin clotting time, beta-thromboglobulin, and fibrino-peptide levels between the control, dihydroergotamine, heparin, and the combination groups.

journal_name

Am J Surg

authors

Kakkar VV,Welzel D,Murray WJ,Malone P,Jones D

subject

Has Abstract

pub_date

1985-10-08 00:00:00

pages

33-8

issue

4A

eissn

0002-9610

issn

1879-1883

journal_volume

150

pub_type

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