Abstract:
BACKGROUND:Peritoneal macrophages play an important role in the immune response after abdominal operations. The stress response after these operations has been associated with impaired phagocytosis by peritoneal macrophages. This study examined the influence of minimally invasive techniques and preoperative corticosteroid administration on postoperative peritoneal macrophage phagocytic activity. METHODS:After IACUC approval, 66 Sprague Dawley rats were randomly divided into 7 groups: baseline animals (B), anesthesia controls (AC), open cecectomy (OC), and laparoscopic cecectomy (LC). Within the AC, OC, and LC groups, half received intraperitoneal (IP) dexamethasone (10 mg/kg) 1 hour before surgery (+S), and the other half received an equal volume of normal saline IP (-S). Animals were observed postoperatively for 24 hours and were then euthanized. Peritoneal macrophages were harvested via intraperitoneal lavage. A phagocytosis assay was performed to calculate the net phagocytosis and percent response to the effector agent. Statistical analysis was performed using analysis of variance and a Student t test between groups. A P value of <.05 was considered significant. RESULTS:Significant differences were observed between groups. The B group had a response rate of 94.2% +/- 56.7%, which was not different from the AC groups (-S, P = .28; +S, P = .16) or the LC-S group (P = .9). The lowest phagocytic activity rate was in the OC-S group with a response rate of 33.8% +/- 28.5%. The highest phagocytic response rates occurred in the AC +S (145.2% +/- 60.2%) and LC +S (198.1% +/- 103.5%). These were not significantly different from each other (P = .3). The LC +S group had a significantly higher percent response than all of the other groups. The phagocytic response rate of the OC +S group was not different from either the AC-S group (P = .07) or the LC-S group (P = .8); however, it was less than the AC +S group (P = .02) and the LC +S group (P = .003). CONCLUSION:Open cecectomy resulted in greater impairment of the phagocytic activity of peritoneal macrophages than laparoscopic cecectomy. The addition of preoperative corticosteroids improved phagocytic activity back to baseline function. The combination of minimally invasive surgical technique and preoperative corticosteroid administration resulted in the greatest postoperative phagocytic function of peritoneal macrophages in a rat model.
journal_name
Am J Surgjournal_title
American journal of surgeryauthors
Schmelzer TM,Heath JJ,Hope WW,Mostafari A,Novitsky YW,Heniford BTdoi
10.1016/j.amjsurg.2008.07.023subject
Has Abstractpub_date
2008-12-01 00:00:00pages
920-4; discussion 924-5issue
6eissn
0002-9610issn
1879-1883pii
S0002-9610(08)00628-4journal_volume
196pub_type
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journal_title:American journal of surgery
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更新日期:1986-08-01 00:00:00
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journal_title:American journal of surgery
pub_type: 评论,杂志文章
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abstract:BACKGROUND:Expression profiles of p21, p27, p53, Ki-67, and thymidylate synthase may be associated with response to neoadjuvant chemoradiation. The relationship between post-treatment protein expression and regional lymph node involvement has not been fully explored. METHODS:Tumor cores from 126 rectal cancer patients...
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abstract::Seroma is a frequent sequelae of neck dissection involving cervical lymphadenectomy. The incidence is correlated with flap elevation, lymphovascular interruption, and tissue removal. Current methods of resolving seroma, such as vacuum drainage, are not risk free. A novel approach to this problem was the use of intraop...
journal_title:American journal of surgery
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journal_title:American journal of surgery
pub_type: 杂志文章,评审
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journal_title:American journal of surgery
pub_type: 杂志文章
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更新日期:2013-04-01 00:00:00
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pub_type: 杂志文章
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journal_title:American journal of surgery
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:1976-06-01 00:00:00
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pub_type: 杂志文章
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更新日期:2015-08-01 00:00:00
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pub_type: 杂志文章
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journal_title:American journal of surgery
pub_type: 传,历史文章,杂志文章
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更新日期:1991-02-01 00:00:00
abstract::Injuries to the inferior vena cava are being seen with increasing frequency in the civilian population. A review of the experience at UCLA/Harbor General Hospital Medical Center over a ten year period (1966 to 1976) discloses thirty-four patients with major injuries to the inferior vena cava, with an overall mortality...
journal_title:American journal of surgery
pub_type: 杂志文章,评审
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更新日期:1977-07-01 00:00:00
abstract::Thirty-two rats had truncal vagotomy either with or without pyloroplasty. After 2 or 4 weeks, respectively, the pancreas was excised and weighed. Measurements of amylase, trypsin, lipase, total protein, and DNA were obtained from the homogenated pancreatic tissue. Isolated pancreatic lobules were incubated with and wi...
journal_title:American journal of surgery
pub_type: 杂志文章
doi:10.1016/0002-9610(89)90615-6
更新日期:1987-09-01 00:00:00
abstract::A recent retrospective study proposed that the following screening criteria be used in identifying critically ill trauma patients receiving aminoglycosides who are at significant risk to develop renal dysfunction: (1) post-admission shock, (2) minimum serum concentration more than 2 mg/L, and (3) diagnosis of septicem...
journal_title:American journal of surgery
pub_type: 临床试验,杂志文章
doi:10.1016/s0002-9610(05)81007-4
更新日期:1990-11-01 00:00:00
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journal_title:American journal of surgery
pub_type: 杂志文章
doi:10.1016/j.amjsurg.2016.11.018
更新日期:2017-08-01 00:00:00
abstract::Recent advances in molecular biology have greatly accelerated knowledge relating to the significance of the enterohepatic circulation of bile salts. This review highlights the role that both oxysterols and bile salts play as ligands which, when bound to nuclear hormone receptors, activate transcription factors that se...
journal_title:American journal of surgery
pub_type: 杂志文章,评审
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更新日期:2003-02-01 00:00:00