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Comparison of bleeding risks related to venous thromboembolism prophylaxis in laparoscopic vs open colorectal cancer surgery: a multicenter study in Japanese patients.

Abstract：

BACKGROUND:Venous thromboembolism is the most common preventable cause of hospital death. The objective of this study was to clarify risk factors for postoperative bleeding related to thromboprophylaxis after laparoscopic colorectal cancer surgery. METHODS:The study was conducted at 23 Japanese institutions and included patients with colorectal cancer who underwent laparoscopic or open surgery followed by fondaparinux treatment. We performed a retrospective analysis from a prospectively maintained database. We used multivariate analyses to evaluate clinical risk factors for prophylaxis-related bleeding events. RESULTS:After multivariate analysis, male gender, intraoperative blood loss of less than 25 mL, and a preoperative platelet count below 15 × 104/μL were found to be independent risk factors in the laparoscopic surgery group. Only the preoperative platelet count was an independent risk factor in the open surgery group. CONCLUSIONS:Different prophylactic treatments for postoperative venous thromboembolism may be necessary in laparoscopic vs open surgery for colorectal cancer.

journal_name

Am J Surg

journal_title

American journal of surgery

authors

Yasui M,Ikeda M,Miyake M,Ide Y,Okuyama M,Shingai T,Kitani K,Ikenaga M,Hasegawa J,Akamatsu H,Murata K,Takemasa I,Mizushima T,Yamamoto H,Sekimoto M,Nezu R,Doki Y,Mori M,Clinical Study Group of Osaka University (CSGO), C

doi

10.1016/j.amjsurg.2015.10.019

subject

Has Abstract

pub_date

2017-01-01 00:00:00

pages

43-49

issue

1

eissn

0002-9610

issn

1879-1883

pii

S0002-9610(15)00674-1

journal_volume

213

pub_type

杂志文章,多中心研究

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