Honokiol induces cytotoxic and cytostatic effects in malignant melanoma cancer cells.

Abstract:

BACKGROUND:Melanomas are aggressive neoplasms with limited therapeutic options. Therefore, developing new therapies with low toxicity is of utmost importance. Honokiol is a natural compound that recently has shown promise as an effective anticancer agent. METHODS:The effect of honokiol on melanoma cancer cells was assessed in vitro. Proliferation and physiologic changes were determined using hexosaminidase assay and transmission electron microscopy. Protein expression was assessed by immunoblotting. RESULTS:Honokiol treatment inhibited cell proliferation and induced death. Electron microscopy showed autophagosome formation. Reduced levels of cyclin D1 accompanied cell-cycle arrest. Honokiol also decreased phosphorylation of AKT (known as protein kinase B) and mammalian target of rapamycin, and inhibited γ-secretase activity by down-regulating the expression of γ-secretase complex proteins, especially anterior pharynx-defective 1. CONCLUSIONS:Honokiol is highly effective in inhibiting melanoma cancer cells by attenuating AKT/mammalian target of rapamycin and Notch signaling. These studies warrant further clinical evaluation for honokiol alone or with present chemotherapeutic regimens for the treatment of melanomas.

journal_name

Am J Surg

authors

Kaushik G,Ramalingam S,Subramaniam D,Rangarajan P,Protti P,Rammamoorthy P,Anant S,Mammen JM

doi

10.1016/j.amjsurg.2012.09.001

subject

Has Abstract

pub_date

2012-12-01 00:00:00

pages

868-73

issue

6

eissn

0002-9610

issn

1879-1883

pii

S0002-9610(12)00515-6

journal_volume

204

pub_type

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