Tension-free hernia repair is associated with an increase in inflammatory response markers against the mesh.

Abstract:

BACKGROUND:The purpose of this study was to evaluate the involvement of inflammatory mediators in patients undergoing Lichtenstein tension-free hernioplasty (LH) using polypropylene prosthetic materials or conventional Bassini hernia repair (BH). METHODS:Thirty patients male with unilateral inguinal hernia without complications or recurrence were included in this study. Randomly, patients underwent LH or BH. Peripheral venous bloods samples were collected 24 hours prior to surgery and then 6, 24, 48 and 168 hours postoperatively. RESULTS:We present evidences that LH patients showed a higher increased serum level of fibrinogen, C-reactive protein, alpha-1-antitrypsin, and interleukin-6 than BH patients. Postoperative visual analogue scales for pain were reduced on mobilization for patients undergoing LH compared with BH. Neutrophils were significantly increased only in LH compared with baseline. Ceruloplasmin, transferrin, and albumin levels were unmodified after BH or LH. CONCLUSIONS:In conclusion our data show that although LH induces less pain and more rapid postoperative recovery, it is associated with an higher inflammatory response compared with BH, likely due to polypropylene mesh.

journal_name

Am J Surg

authors

Di Vita G,Milano S,Frazzetta M,Patti R,Palazzolo V,Barbera C,Ferlazzo V,Leo P,Cillari E

doi

10.1016/s0002-9610(00)00445-1

subject

Has Abstract

pub_date

2000-09-01 00:00:00

pages

203-7

issue

3

eissn

0002-9610

issn

1879-1883

pii

S0002-9610(00)00445-1

journal_volume

180

pub_type

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