Abstract:
:The addition of a T-cell growth-promoting medium (PHA-TCM) to culture conditions that support growth of multi-lineage hemopoietic colonies enhances the proliferation of cells with lymphoid morphology within these colonies. These cells were identified as T lymphocytes by their ability to form rosettes with SRBC and their reaction with monoclonal antibodies (OKT3, OKT4) directed against T-cell-specific surface components. They continue to proliferate extensively under the influence of PHA-TCM after transfer of mixed colonies into liquid suspension culture. Supportive evidence for a common progenitor of myeloid and lymphoid cells within single mixed colonies is provided by Y-chromatin body analysis of E-rosette positive and negative cells in colonies grown in cocultures of male and female bone marrow cells.
journal_name
Bloodjournal_title
Bloodauthors
Messner HA,Izaquirre CA,Jamal Nsubject
Has Abstractpub_date
1981-08-01 00:00:00pages
402-5issue
2eissn
0006-4971issn
1528-0020journal_volume
58pub_type
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