SH2 domain-mediated targeting, but not localization, of Syk in the plasma membrane is critical for FcepsilonRI signaling.

abstract：:The expansion of follicular lymphomas (FLs) resembles, both morphologically and functionally, normal germinal center B-cell growth. The tumor cells proliferate in networks of follicular dendritic cells and are believed to be capable of somatic hypermutation and isotype switching. To investigate the relation between so...

journal_title：Blood

authors： Aarts WM,Bende RJ,Steenbergen EJ,Kluin PM,Ooms EC,Pals ST,van Noesel CJ

更新日期：2000-05-01 00:00:00

abstract：:CD10/neutral endopeptidase 24.11 (NEP) regulates peptidemediated proliferation of lymphoid progenitors and certain epithelial cells and is itself regulated by cellular proliferation. To further characterize mechanisms by which cell-surface signaling might regulate CD10/NEP expression, we determined whether CD10/NEP wa...

journal_title：Blood

authors： Ganju RK,Shpektor RG,Brenner DG,Shipp MA

更新日期：1996-12-01 00:00:00

abstract：:We have studied a family with homozygous lethal, blood coagulation factor VII (FVII) deficiency. To identify the mutation responsible for the deficiency, exons 2 to 8 and the intron-exon junctions of their FVII genes were amplified from peripheral white blood cell DNA by polymerase chain reaction and screened by singl...

journal_title：Blood

authors： McVey JH,Boswell EJ,Takamiya O,Tamagnini G,Valente V,Fidalgo T,Layton M,Tuddenham EG

更新日期：1998-08-01 00:00:00

abstract：:Age-associated clonal hematopoiesis caused by acquired mutations in myeloid cancer-associated genes is highly prevalent in the normal population. Its etiology, biological impact on hematopoiesis, and oncogenic risk is poorly defined at this time. To gain insight into this phenomenon, we analyzed a cohort of 2530 relat...

journal_title：Blood

authors： Buscarlet M,Provost S,Zada YF,Barhdadi A,Bourgoin V,Lépine G,Mollica L,Szuber N,Dubé MP,Busque L

更新日期：2017-08-10 00:00:00

abstract：:Previous analyses of the roles of alpha4 integrins in hematopoiesis by other groups have led to conflicting evidence. alpha4 integrin mutant cells developing in [alpha4 integrin(-/-): wt] chimeric mice are not capable of completing lymphomyeloid differentiation, whereas conditional inactivation of alpha4 integrin in a...

journal_title：Blood

authors： Gribi R,Hook L,Ure J,Medvinsky A

更新日期：2006-07-15 00:00:00

abstract：:Factor V Leiden (factor V Arg506Gln), the genetic defect underlying resistance to activated protein C, is the most common risk factor for venous thrombosis. The relationship between this genetic abnormality and arterial disease is still unresolved. To assess whether factor V Leiden increases the risk of myocardial inf...

journal_title：Blood

authors： Rosendaal FR,Siscovick DS,Schwartz SM,Beverly RK,Psaty BM,Longstreth WT Jr,Raghunathan TE,Koepsell TD,Reitsma PH

更新日期：1997-04-15 00:00:00

abstract：:Some patients lose chimerism following nonmyeloablative hematopoietic cell transplantation (HCT), yet, surprisingly, enjoy sustained tumor remissions. We hypothesized that host-versus-graft (HVG) alloresponses might induce antitumor effects against recipient tumors. We explored this question in mice by administering r...

journal_title：Blood

authors： Rubio MT,Kim YM,Sachs T,Mapara M,Zhao G,Sykes M

更新日期：2003-09-15 00:00:00

abstract：:Molecular diagnostics has generated substantial dividends in dissecting the genetic basis of myeloid neoplasms with eosinophilia. The family of diseases generated by dysregulated fusion tyrosine kinase (TK) genes is recognized by the World Health Organization (WHO) category, "Myeloid/lymphoid neoplasms with eosinophil...

journal_title：Blood

authors： Reiter A,Gotlib J

更新日期：2017-02-09 00:00:00

abstract：:We have identified a small molecular weight compound, SCH 14988, which specifically stimulates in vitro granulocyte-colony stimulating factor (G-CSF) production from activated human peripheral blood mononuclear cells and monocytes but not other cytokines or CSFs with hematoregulatory activity. In vivo administration o...

journal_title：Blood

authors： Fine JS,Cai XY,Justice L,Gommoll CP Jr,Hamilton LD,Waters TA,Narula SK,Bober LA,Grace MJ

更新日期：1997-07-15 00:00:00

abstract：:The effects of transforming growth factor-beta 1 (TGF-beta 1) on proliferation and hemoglobinization in K-562 cells, a human multipotential hematopoietic cell line, were studied. We found that TGF-beta 1 could induce hemoglobin accumulation in K-562 cells. Various clones were selected on the basis of the inducibility ...

journal_title：Blood

authors： Chen LL,Dean A,Jenkinson T,Mendelsohn J

更新日期：1989-11-15 00:00:00

abstract：:Investigators in the United Kingdom have shown that hereditary amyloidosis can be misdiagnosed as Ig light-chain (AL) amyloidosis because family history is an ineffective screen, and tissue staining used to type amyloid is unreliable. Misdiagnosis of AL can lead to inappropriate use of chemotherapy and failure to diag...

journal_title：Blood

authors： Comenzo RL,Zhou P,Fleisher M,Clark B,Teruya-Feldstein J

更新日期：2006-05-01 00:00:00

abstract：:Reconstitution of cellular immunity by 3 months after hematopoietic stem cell transplantation (HSCT) is a critical determinant of the long-term success of the transplantation. We analyzed the factors affecting recovery of cytomegalovirus (CMV)-specific CD4+ and CD8+ function at 3 months after HSCT by univariate and mu...

journal_title：Blood

authors： Hakki M,Riddell SR,Storek J,Carter RA,Stevens-Ayers T,Sudour P,White K,Corey L,Boeckh M

更新日期：2003-10-15 00:00:00

abstract：:Single-center experiences have shown that intensified treatments with autologous transplantation are a promising therapeutic strategy for patients with high-risk follicle-center lymphoma (FCL) at diagnosis, whereas data from prospective multicenter trials are still lacking. This paper describes the results of a prospe...

journal_title：Blood

authors： Ladetto M,Corradini P,Vallet S,Benedetti F,Vitolo U,Martelli M,Brugiatelli M,Coser P,Perrotti A,Majolino I,Fioritoni G,Morandi S,Musso M,Zambello R,Chisesi T,Di Renzo N,Vivaldi P,De Crescenzo A,Gallamini A,Salvi F,

更新日期：2002-09-01 00:00:00

abstract：:Gadd45a has been involved in DNA damage response and in many malignancies, including leukemia. However, the function of Gadd45a in hematopoietic stem cells (HSCs) remains unknown. Here, we reported that Gadd45a-deficient (Gadd45a(-/-)) mice showed a normal hematologic phenotype under homeostatic conditions. However, f...

journal_title：Blood

authors： Chen Y,Ma X,Zhang M,Wang X,Wang C,Wang H,Guo P,Yuan W,Rudolph KL,Zhan Q,Ju Z

更新日期：2014-02-06 00:00:00

abstract：:Most patients with chronic lymphocytic leukemia (CLL) are diagnosed with early-stage disease and managed with active surveillance. The individual course of patients with early-stage CLL is heterogeneous, and their probability of needing treatment is hardly anticipated at diagnosis. We aimed at developing an internatio...

journal_title：Blood

authors： Condoluci A,Terzi di Bergamo L,Langerbeins P,Hoechstetter MA,Herling CD,De Paoli L,Delgado J,Rabe KG,Gentile M,Doubek M,Mauro FR,Chiodin G,Mattsson M,Bahlo J,Cutrona G,Kotaskova J,Deambrogi C,Smedby KE,Spina V,Brusc

更新日期：2020-05-21 00:00:00

abstract：:Antithymocyte globulin (ATG) has recently been popularized as an effective treatment in myelodysplastic syndrome (MDS). We treated 8 anemic MDS patients (refractory anemia [RA] and refractory anemia with excess blasts [RAEB-1]) with ATG (40 mg/kg/d for 4 days) and prednisone in a phase 2 trial. The study was stopped e...

journal_title：Blood

authors： Steensma DP,Dispenzieri A,Moore SB,Schroeder G,Tefferi A

更新日期：2003-03-15 00:00:00

abstract：:We performed a pilot study to test the effectiveness of allogeneic bone marrow transplantation in the treatment of chronic myelogenous leukemia. Five patients in the advanced stages of chronic myelogenous leukemia (four in blast crisis, one in accelerated phase) with abnormal chromosomes underwent matched-sibling allo...

journal_title：Blood

authors： McGlave PB,Miller WJ,Hurd DD,Arthur DC,Kim T

更新日期：1981-11-01 00:00:00

abstract：:Haploinsufficiency of ribosomal proteins (RPs) has been proposed to be the common basis for the anemia observed in Diamond-Blackfan anemia (DBA) and myelodysplastic syndrome with loss of chromosome 5q [del(5q) MDS]. We have modeled DBA and del(5q) MDS in zebrafish using antisense morpholinos to rps19 and rps14, respec...

journal_title：Blood

authors： Payne EM,Virgilio M,Narla A,Sun H,Levine M,Paw BH,Berliner N,Look AT,Ebert BL,Khanna-Gupta A

更新日期：2012-09-13 00:00:00

abstract：:The recombinant thrombopoietins have been shown to be effective stimulators of platelet production in cancer patients. It was therefore of interest to determine if one of these, pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF), could be used to increase platelet counts and conseque...

journal_title：Blood

authors： Kuter DJ,Goodnough LT,Romo J,DiPersio J,Peterson R,Tomita D,Sheridan W,McCullough J

更新日期：2001-09-01 00:00:00

abstract：:Complex molecular mechanisms control B-cell fate to become a memory or a plasma cell. Interleukin-24 (IL-24) is a class II family cytokine of poorly understood immune function that regulates the cell cycle. We previously observed that IL-24 is strongly expressed in leukemic memory-type B cells. Here we show that IL-24...

journal_title：Blood

authors： Maarof G,Bouchet-Delbos L,Gary-Gouy H,Durand-Gasselin I,Krzysiek R,Dalloul A

更新日期：2010-03-04 00:00:00

abstract：:Histone deacetylases (HDACs) are epigenetic erasers of lysine-acetyl marks. Inhibition of HDACs using small molecule inhibitors (HDACi) is a potential strategy in the treatment of various diseases and is approved for treating hematological malignancies. Harnessing the therapeutic potential of HDACi requires knowledge ...

journal_title：Blood

authors： Heideman MR,Wilting RH,Yanover E,Velds A,de Jong J,Kerkhoven RM,Jacobs H,Wessels LF,Dannenberg JH

更新日期：2013-03-14 00:00:00

abstract：:Monitoring unfractionated heparin (UFH) is crucial to prevent over- or under-anticoagulation. However, the optimal parameters for monitoring UFH in children are not well established. The study objectives were to investigate (1) the relationship between UFH dose and its anticoagulant effect as assessed by anti-Xa, acti...

journal_title：Blood

authors： Hanslik A,Kitzmüller E,Tran US,Thom K,Karapetian H,Prutsch N,Voitl J,Michel-Behnke I,Newall F,Male C

更新日期：2015-10-29 00:00:00

abstract：:Tissue factor (TF), the cellular receptor for factor VIIa (FVIIa), besides initiating blood coagulation, is believed to play an important role in tissue repair, inflammation, angiogenesis, and tumor metastasis. Like TF, the chemokine interleukin-8 (IL-8) is shown to play a critical role in these processes. To elucidat...

journal_title：Blood

authors： Hjortoe GM,Petersen LC,Albrektsen T,Sorensen BB,Norby PL,Mandal SK,Pendurthi UR,Rao LV

更新日期：2004-04-15 00:00:00

abstract：:One of the most serious complications of successful treatments for Hodgkin's disease is an increased incidence of acute nonlymphocytic leukemia (ANLL) and other malignancies. A retrospective analysis carried out on 1032 consecutive patients with Hodgkin's disease admitted to our Institute between 1965 and 1978 and tre...

journal_title：Blood

authors： Valagussa P,Santoro A,Fossati Bellani F,Franchi F,Banfi A,Bonadonna G

更新日期：1982-03-01 00:00:00

abstract：:The mechanical properties of sickle erythrocyte membranes were evaluated in the ektacytometer. When ghosts from the total red blood cell population were examined, the rigidity of the resealed ghosts and their rate of fragmentation by shear stress (t1/2) were normal. However, fractionation on Stractan density gradients...

journal_title：Blood

authors： Messmann R,Gannon S,Sarnaik S,Johnson RM

更新日期：1990-04-15 00:00:00

abstract：:Infection by human immunodeficiency virus type 1 (HIV-1) results in a progressive depletion of CD4+ T lymphocytes, leading to fatal immunodeficiency. The mechanisms causing the marked loss of CD4+ T lymphocytes are incompletely understood. However, several lines of evidence indicate that direct cytopathology mediated ...

journal_title：Blood

authors： Cantin R,Fortin JF,Lamontagne G,Tremblay M

更新日期：1997-08-01 00:00:00

abstract：:Interleukin-21 (IL-21) is a recently described immunoregulatory cytokine. It has been identified as a very potent immunotherapeutic agent in several cancer types in animal models, and clinical studies are ongoing. IL-21 belongs to the type I cytokine family of which other members, ie, IL-2, IL-15, and IL-4, have been ...

journal_title：Blood

authors： Castermans K,Tabruyn SP,Zeng R,van Beijnum JR,Eppolito C,Leonard WJ,Shrikant PA,Griffioen AW

更新日期：2008-12-15 00:00:00

abstract：:Retrospective studies of patients with thrombotic microangiopathies (TMAs) have shown that a deficient activity of von Willebrand factor (vWF)-cleaving protease is involved in thrombotic thrombocytopenic purpura (TTP) but not in the hemolytic-uremic syndrome (HUS). To further analyze the relevance of this enzymatic ac...

journal_title：Blood

authors： Veyradier A,Obert B,Houllier A,Meyer D,Girma JP

更新日期：2001-09-15 00:00:00

abstract：:Before the contemporary development of rationally designed antineoplastic therapies, cladribine was identified as a lymphocyte-specific agent. Its profound impact on the natural history of hairy cell leukemia, with responses approaching 100% and a median duration of response of nearly a decade after only a single 7-da...

journal_title：Blood

authors： Sigal DS,Miller HJ,Schram ED,Saven A

更新日期：2010-10-21 00:00:00

abstract：:Stem cell homing into the bone microenvironment is the first step in the initiation of marrow-derived blood cells. It is reported that human severe combined immunodeficient (SCID) repopulating cells home and accumulate rapidly, within a few hours, in the bone marrow and spleen of immunodeficient mice previously condit...

journal_title：Blood

authors： Kollet O,Spiegel A,Peled A,Petit I,Byk T,Hershkoviz R,Guetta E,Barkai G,Nagler A,Lapidot T

更新日期：2001-05-15 00:00:00