Abstract:
:The principles and historical development of clinical trials are outlined briefly. Some issues that extend the basic philosophy first put forward by Sir Austin Bradford Hill 40 years ago and that will need consideration in the future application of clinical trials are discussed.
journal_name
Stat Medjournal_title
Statistics in medicineauthors
Holland WW,Breeze E,Swan AVdoi
10.1002/sim.4780010414subject
Has Abstractpub_date
1982-10-01 00:00:00pages
361-8issue
4eissn
0277-6715issn
1097-0258journal_volume
1pub_type
传,历史文章,杂志文章abstract::We develop analysis methods for clinical trials with time-to-event outcomes which correct for treatment changes during follow-up, yet are based on comparisons of randomized groups and not of selected groups. A causal model relating observed event times to event times that would have been observed under other treatment...
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journal_title:Statistics in medicine
pub_type: 杂志文章
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abstract::The coefficient of individual equivalence is a permutation-based measure of agreement between two observers making replicated readings on each subject. It compares the observed disagreement between the observers to the expected disagreement under individual equivalence. Individual equivalence of observers requires tha...
journal_title:Statistics in medicine
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journal_title:Statistics in medicine
pub_type: 杂志文章
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更新日期:1989-12-01 00:00:00
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
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journal_title:Statistics in medicine
pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2002-11-30 00:00:00
abstract::We propose to use a very simple model to test whether a cancer cluster is due to chance alone. We focus on the acute childhood leukaemia cluster in Columbus, Ohio. In 1975, 12 leukaemia cases were observed in Columbus while the expected number is 6 cases per year. According to our simple model, the probability of such...
journal_title:Statistics in medicine
pub_type: 杂志文章
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更新日期:2000-08-30 00:00:00
abstract::Quality of life (QOL) assessment is a key component of many clinical studies and frequently requires the use of single global summary measures that capture the overall balance of findings from a potentially wide-ranging assessment of QOL issues. We propose and evaluate an irregular multilevel latent variable model sui...
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journal_title:Statistics in medicine
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更新日期:2014-02-10 00:00:00
abstract::Box-Cox transformation is investigated for regression models for left-censored data. Examples are provided using coronary calcification data from the Multi-Ethnic Study of Atherosclerosis and pharmacokinetic data of a nicotine nasal spray. ...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.1925
更新日期:2004-12-15 00:00:00
abstract::Both the variation of positive responses (negative responses) among individuals and the internal correlation among responses for the same individual affect the precision of the estimate of sensitivity (specificity). To estimate the sensitivity (specificity) of a medical diagnostic test, this paper proposes a Bayesian ...
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pub_type: 杂志文章
doi:10.1002/sim.4780081007
更新日期:1989-10-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1002/sim.1180
更新日期:2002-07-30 00:00:00
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journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.1120
更新日期:2002-05-30 00:00:00
abstract::To study the effect of a mega hydropower dam in southwest Ethiopia on malaria incidence, we have set up a longitudinal study. To gain insight in temporal and spatial aspects, that is, in time (period = year-season combination) and location (village), we need models that account for these effects. The frailty model w...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.5752
更新日期:2013-08-15 00:00:00
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pub_type: 杂志文章
doi:10.1002/sim.2397
更新日期:2005-12-30 00:00:00
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pub_type: 杂志文章
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journal_title:Statistics in medicine
pub_type: 临床试验,杂志文章,随机对照试验
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