Direct effect of cortisol and cortisone on insulin and glucagon secretion.

abstract：:Recent evidence indicates that catecholamines may directly alter anterior pituitary function. In the present study, an in vitro perifusion system was used to investigate whether catecholamines affect the gonadotrope. Pituitary tissue from castrated ram lambs was incubated in the presence of epinephrine (EPI), norepine...

journal_title：Endocrinology

authors： Swartz SR,Moberg GP

更新日期：1986-06-01 00:00:00

abstract：:Several lines of indirect evidence suggest that a monocyte family precursor gives rise to the osteoclast, although this hypothesis is controversial. Starting with a uniform population of nonspecific esterase positive, tartrate-sensitive, acid phosphatase-producing, mannose receptor-bearing mononuclear cells, prepared ...

journal_title：Endocrinology

authors： Alvarez JI,Teitelbaum SL,Blair HC,Greenfield EM,Athanasou NA,Ross FP

更新日期：1991-05-01 00:00:00

abstract：:Mammary gland explants from mature virgin mice, rats, and rabbits exhibit an increased rate of both DNA and casein syntheses when cultured in the presence of specific combinations of insulin, hydrocortisone, and PRL. If cytosine arabinoside, a potent inhibitor of DNA synthesis, is added to the culture medium, casein s...

journal_title：Endocrinology

authors： Nicholas KR,Bolander FF Jr,Sankaran L,Topper YJ

更新日期：1983-03-01 00:00:00

abstract：:We have recently disclosed sustained episodes of LH release (minisurges) during the afternoons of the juvenile-peripubertal transition period in the female rat. To determine if these LH minisurges are gonad independent, i.e. develop in the absence of the ovaries, animals were ovariectomized when neonates, and the mode...

journal_title：Endocrinology

authors： Urbanski HF,Ojeda SR

更新日期：1986-03-01 00:00:00

abstract：:Cysteamine [2-aminoethanethiol (CySH)] reduces measurable PRL concentrations in vivo and in vitro. Since secretion is also inhibited, CySH may block conversion from a poorly assayable hormone storage form(s) to readily assayable, releasable PRL. This would represent a previously unrecognized mechanism for secretory re...

journal_title：Endocrinology

authors： Lorenson MY,Jacobs LS

更新日期：1984-10-01 00:00:00

abstract：:GH and IGF-I control over 80% of postnatal growth. We recently established that TNFalpha impairs the ability of IGF-I to increase protein synthesis and promote expression of myogenin in myoblasts. Here we extend these results by showing that ceramide, a second messenger in both TNFalpha and IL-1beta receptor signaling...

journal_title：Endocrinology

authors： Strle K,Broussard SR,McCusker RH,Shen WH,Johnson RW,Freund GG,Dantzer R,Kelley KW

更新日期：2004-10-01 00:00:00

abstract：:Somatostatin (SRIH) inhibits cell proliferation by interacting with five distinct SRIH receptor subtypes (SSTRs) activating several pathways in many tissues. We previously demonstrated that SRIH, by activating Src homology-2-containing protein, inhibits cell proliferation of the human medullary thyroid carcinoma cell ...

journal_title：Endocrinology

authors： Tagliati F,Zatelli MC,Bottoni A,Piccin D,Luchin A,Culler MD,Degli Uberti EC

更新日期：2006-07-01 00:00:00

abstract：:Dehydroepiandrosterone (DHEA) and its sulfate ester are the most abundant circulating adrenal steroids in humans. Administration of DHEA has been reported to have beneficial effects on obesity, hyperlipidemia, diabetes, and atherosclerosis in obese rodents, although its effects on insulin resistance have not been full...

journal_title：Endocrinology

authors： Kimura M,Tanaka S,Yamada Y,Kiuchi Y,Yamakawa T,Sekihara H

更新日期：1998-07-01 00:00:00

abstract：:Down regulation of insulin receptor number by insulin at physiological concentrating (10(-9) M) has been demonstrated in primary cultures of adult rat liver parenchymal cells in monolayer. However, because insulin is rapidly degraded in this culture system, special efforts are necessary to maintain the concentration o...

journal_title：Endocrinology

authors： Blackard WG,Guzelian PS,Small ME

更新日期：1978-08-01 00:00:00

abstract：:The gastrointestinal tract of the pig undergoes enhanced growth as well as morphological and functional differentiation during the perinatal period. Concurrently, porcine neonates ingest physiologically significant amounts of insulin-like growth factor-I (IGF-I) via colostrum and milk. The objectives of this study wer...

journal_title：Endocrinology

authors： Schober DA,Simmen FA,Hadsell DL,Baumrucker CR

更新日期：1990-02-01 00:00:00

abstract：:Estradiol is known to inhibit antigen presentation in the vagina. We report here that TGFbeta mediates the action of estradiol on vaginal antigen presenting cells (APC). When vaginal APC from ovariectomized rats were incubated with increasing concentrations of TGFbeta1 and TGFbeta2 in the presence of ovalbumin-specifi...

journal_title：Endocrinology

authors： Wira CR,Roche MA,Rossoll RM

更新日期：2002-08-01 00:00:00

abstract：:Levels of insulin-like growth factor-I (IGF-I), IGF-II, and IGF-binding proteins (IGFBPs) were studied in ovine follicular fluid and serum with a view to determining their respective endocrine and/or paracrine roles in ovarian folliculogenesis. Ovarian follicles of Ile-de-France ewes were dissected and measured indivi...

journal_title：Endocrinology

authors： Monget P,Monniaux D,Pisselet C,Durand P

更新日期：1993-04-01 00:00:00

abstract：:Estrogen or raloxifene (LY156758) prevent estrogen deficiency-induced bone loss in animals and humans. We demonstrated in the rat that a 22% reduction in bone mineral density generated by ovariectomy was associated with a 2-fold reduction of transforming growth factor-beta 3 (TGF beta 3) messenger RNA expression in th...

journal_title：Endocrinology

authors： Yang NN,Bryant HU,Hardikar S,Sato M,Galvin RJ,Glasebrook AL,Termine JD

更新日期：1996-05-01 00:00:00

abstract：:Hypophyseotropic dopamine exerts a tonic inhibitory tone on pituitary lactotrophs by the activation of dopamine D2 receptors (D2R). Ablation of D2R through gene knock-out approaches results in hyperprolactinemia and prolactinomas. This phenotype is more severe and develops more rapidly in female mice. We tested whethe...

journal_title：Endocrinology

authors： Hentges ST,Low MJ

更新日期：2002-12-01 00:00:00

abstract：:The present study investigated whether activation of the hexosamine biosynthesis pathway might mediate at least in part the high glucose effect on angiotensinogen (ANG) gene expression and immortalized renal proximal tubular cell (IRPTC) hypertrophy. IRPTC were cultured in monolayer. ANG, renin, and beta-actin mRNA ex...

journal_title：Endocrinology

authors： Hsieh TJ,Fustier P,Zhang SL,Filep JG,Tang SS,Ingelfinger JR,Fantus IG,Hamet P,Chan JS

更新日期：2003-10-01 00:00:00

abstract：:We reported previously that chromogranin A (Chga) knockout (KO) mice are hypertensive and hyperadrenergic. Here we sought to determine the basis of such alterations by probing physiological, biochemical, and pharmacological responses to perturbations of the autonomic nervous system. In the conscious state, KO mice had...

journal_title：Endocrinology

authors： Gayen JR,Gu Y,O'Connor DT,Mahata SK

更新日期：2009-11-01 00:00:00

abstract：:Alterations in the maternal endocrine, nutritional, and metabolic environment disrupt the developmental trajectory of the fetus, leading to adult diseases. Female offspring of rats, subhuman primates, and sheep treated prenatally with testosterone (T) develop reproductive/metabolic defects during adult life similar to...

journal_title：Endocrinology

authors： Manikkam M,Crespi EJ,Doop DD,Herkimer C,Lee JS,Yu S,Brown MB,Foster DL,Padmanabhan V

更新日期：2004-02-01 00:00:00

abstract：:This study was undertaken to identify uterine insulin-like growth factor-I (IGF-I) receptors and examine the regulation of these receptors throughout the estrous cycle and after 17 beta-estradiol (E2) administration to immature rats. We have demonstrated type I IGF receptors in crude uterine membranes by binding and c...

journal_title：Endocrinology

authors： Ghahary A,Murphy LJ

更新日期：1989-08-01 00:00:00

abstract：:The hepatic extractions of gastric inhibitory polypeptide (GIP) and insulin were determined using in vitro and in vivo methods to assess the role of the liver in GIP metabolism and the possible effect of GIP on the hepatic extraction of insulin. During in vitro studies using the isolated perfused rat liver, infusion o...

journal_title：Endocrinology

authors： Hanks JB,Andersen DK,Wise JE,Putnam WS,Meyers WC,Jones RS

更新日期：1984-09-01 00:00:00

abstract：:Insulin-like growth factor-I (IGF-I), the principal IGF in adult rat serum, occurs complexed to specific binding proteins. After fractionation of serum on Sephadex G-200 at neutral pH, 62% of the immunoreactive IGF-I is recovered in the 150K region, 38% in the 40K region, and none is present as free 7.5K IGF-I. Adult ...

journal_title：Endocrinology

authors： Yang YW,Wang JF,Orlowski CC,Nissley SP,Rechler MM

更新日期：1989-09-01 00:00:00

abstract：:PRL and placental lactogen (PL) play key roles in maintaining the rodent corpus luteum through pregnancy. Suppressors of cytokine signaling (SOCS) have been shown to decrease cell sensitivity to cytokines, including PRL, and so here we have addressed the issue of whether luteolysis induced by prostaglandin F(2alpha) (...

journal_title：Endocrinology

authors： Curlewis JD,Tam SP,Lau P,Kusters DH,Barclay JL,Anderson ST,Waters MJ

更新日期：2002-10-01 00:00:00

abstract：:Nitric oxide (NO) has emerged as an intracellular and intercellular messenger in a number of biological systems. In the present study, we demonstrated that NO was produced by cultured rat Leydig cells, and that inducible nitric oxide synthase (iNOS) messenger RNA (mRNA) was expressed in Leydig cells. NO was measured a...

journal_title：Endocrinology

authors： Tatsumi N,Fujisawa M,Kanzaki M,Okuda Y,Okada H,Arakawa S,Kamidono S

更新日期：1997-03-01 00:00:00

abstract：:GnRH neurons are central regulators of reproduction and respond to factors affecting fertility, such as stress. Corticotropin-releasing hormone (CRH) is released during stress response. In brain slices from unstressed controls, CRH has opposite, estradiol-dependent effects on GnRH neuron firing depending on the CRH re...

journal_title：Endocrinology

authors： Phumsatitpong C,De Guzman RM,Zuloaga DG,Moenter SM

更新日期：2020-11-01 00:00:00

abstract：:The effects of cilostazol, a dual inhibitor of type 3 phosphodiesterase and adenosine uptake, on ion currents were investigated in pituitary GH(3) cells and pheochromocytoma PC12 cells. In whole-cell configuration, cilostazol (10 microm) reversibly increased the amplitude of Ca(2+)-activated K(+) current [I(K(Ca))]. C...

journal_title：Endocrinology

authors： Wu SN,Liu SI,Huang MH

更新日期：2004-03-01 00:00:00

abstract：:As the regulator of pituitary reproductive hormone synthesis, the hypothalamic neuropeptide GnRH is the central regulator of reproduction. A hallmark of GnRH action is the differential control of gene expression in pituitary gonadotropes through varied pulsatile stimulation. Among other signaling events, GnRH activati...

journal_title：Endocrinology

authors： Nguyen KA,Intriago RE,Upadhyay HC,Santos SJ,Webster NJ,Lawson MA

更新日期：2010-10-01 00:00:00

abstract：:Leptin enhances the glucose utilization in most insulin target tissues and paradoxically decreases it in white adipose tissue (WAT), but knowledge of the mechanisms underlying the inhibitory effect of central leptin on the insulin-dependent glucose uptake in WAT is limited. After 7 d intracerebroventricular leptin tre...

journal_title：Endocrinology

authors： Bonzón-Kulichenko E,Fernández-Agulló T,Moltó E,Serrano R,Fernández A,Ros M,Carrascosa JM,Arribas C,Martínez C,Andrés A,Gallardo N

更新日期：2011-04-01 00:00:00

abstract：:GnRH autoregulates GnRH neurons through an ultrashort feedback loop. One potential mechanism is the regulation of K(+) channel activity through the GnRH receptor. Whereas GnRH inhibits the activity of the M-current in peripheral neurons, there is no direct evidence that the M-current is involved in the autoregulatory ...

journal_title：Endocrinology

authors： Xu C,Roepke TA,Zhang C,Rønnekleiv OK,Kelly MJ

更新日期：2008-05-01 00:00:00

abstract：:To begin to assess the function of the cell cycle regulator cyclin D3 during gametogenesis, the present study examined its expression, interacting partners, and associated kinase activity in the murine testis and ovary. In the early stages of postnatal testicular development, cyclin D3 protein was detected in spermato...

journal_title：Endocrinology

authors： Zhang Q,Wang X,Wolgemuth DJ

更新日期：1999-06-01 00:00:00

abstract：:The ability of the adult pancreas to generate new insulin (beta) cells has been controversial because of difficulties in unequivocally identifying the precursor population. We recently determined that beta cells were generated during development from precursors that expressed the homeodomain-containing transcription f...

journal_title：Endocrinology

authors： Fernandes A,King LC,Guz Y,Stein R,Wright CV,Teitelman G

更新日期：1997-04-01 00:00:00

abstract：:Mice lacking steroid 5 alpha-reductase 1 and 2 were produced by gene targeting and breeding. Male mice without 5 alpha-reductase 2 or without both enzymes had fully formed internal and external genitalia and were fertile, but had smaller prostates and seminal vesicles than controls. T accumulated to high levels in the...

journal_title：Endocrinology

authors： Mahendroo MS,Cala KM,Hess DL,Russell DW

更新日期：2001-11-01 00:00:00