Abstract:
:Two threshold models, a single locus model, and two combined models are fitted to data on familial incidence of bipolar affective disorder in 194 nuclear families ascertained through a bipolar proband. The relative fit of alternative transmission models is tested by a likelihood ratio chi-square with the degrees of freedom defined by the difference in the number of parameters estimated by each model. All parameters are estimated by the method of maximum likelihood. The simplest threshold model, permitting only a single background familial correlation, is found to provide a statistically poorer fit than any of the alternative models, and may be rejected as a model for the etiology of bipolar affective disorder. The four remaining models are statistically indistinguishable. It is suggested, however, that the involvement of a major locus in the etiology of this disorder deserves further scrutiny since any of the models incorporating a major locus, with or without a multifactorial background, are consistently associated with greater likelihoods than the complex threshold model. It is also noted that diagnostic criteria are critical in the analysis. In the present study, relatives of probands are considered affected if a diagnosis of bipolar or unipolar affective disorder is present. When only bipolar relatives are considered affected, none of the transmission models may be rejected. Finally, the results of these analyses are found to be independent of the ascertainment parameter.
journal_name
Am J Phys Anthropoljournal_title
American journal of physical anthropologyauthors
O'Rourke DH,McGuffin P,Reich Tdoi
10.1002/ajpa.1330620108subject
Has Abstractpub_date
1983-09-01 00:00:00pages
51-9issue
1eissn
0002-9483issn
1096-8644journal_volume
62pub_type
杂志文章abstract::Nine human mandibular first premolars were examined to assess variation in external morphology and enamel structural organization within a tooth type. The relationship of enamel ultrastructure to gross dental morphology was also studied. The teeth were cut in the mesiodistal direction just lingual to the buccal cusp, ...
journal_title:American journal of physical anthropology
pub_type: 杂志文章
doi:10.1002/ajpa.1330680207
更新日期:1985-10-01 00:00:00
abstract::At least 29 species of fossil primates have been referred to fruit, nectar, and/or exudate feeding dietary niches. Many studies have detailed the morphological correlates of fruit feeding in comparison to insectivory and folivory. In contrast, few studies have sought to differentiate the morphological correlates of fr...
journal_title:American journal of physical anthropology
pub_type: 杂志文章
doi:10.1002/(SICI)1096-8644(199702)102:2<187::AID-AJPA
更新日期:1997-02-01 00:00:00
abstract::A new genus and species of notharctine primate, Hesperolemur actius, is described from Uintan (middle Eocene) aged rocks of San Diego County, California. Hesperolemur differs from all previously described adapiforms in having the anterior third of the ectotympanic anulus fused to the internal lateral wall of the audit...
journal_title:American journal of physical anthropology
pub_type: 杂志文章
doi:10.1002/ajpa.1330980406
更新日期:1995-12-01 00:00:00
abstract::The fingers in the adult human hand differ in length and in distal extent. The literature agrees that in the clear majority of males, the distal extent of the ring finger tends to be relatively greater (using the middle finger as standard) than the index finger. However, the results for females vary considerably, with...
journal_title:American journal of physical anthropology
pub_type: 杂志文章
doi:10.1002/ajpa.10029
更新日期:2002-03-01 00:00:00
abstract::A very limiting factor for paleoanthropological studies is the poor state of preservation of the human fossil record, where fragmentation and deformation are considered normal. Although anatomical information can still be gathered from a distorted fossil, such specimens must typically be excluded from advanced morphol...
journal_title:American journal of physical anthropology
pub_type: 杂志文章
doi:10.1002/ajpa.22376
更新日期:2014-01-01 00:00:00
abstract::This study examines quantification techniques applicable to human skeletal remains, and in particular the Lincoln index (LI), the minimum number of individuals (MNI), and what we refer to as the most likely number of individuals (MLNI), which is a modification of the LI by Chapman ([1951] Univ. Calif. Publ. Stat. 1:13...
journal_title:American journal of physical anthropology
pub_type: 杂志文章
doi:10.1002/ajpa.10381
更新日期:2004-10-01 00:00:00
abstract::Hair slope, whorl, cross and field formation is expressible in a topological form. The mathematical description required suggests an origin for the patterns in a growth process occurring in the upper dermis which determines the patterns of the hair slope. The formulae proposed by Euler, Poincaré and Ludwig are adopted...
journal_title:American journal of physical anthropology
pub_type: 杂志文章
doi:10.1002/ajpa.1330460308
更新日期:1977-05-01 00:00:00
abstract:OBJECTIVES:African American populations in the U.S. formed primarily by mating between Africans and Europeans over the last 500 years. To date, studies of admixture have focused on either a one-time admixture event or continuous input into the African American population from Europeans only. Our goal is to gain a bette...
journal_title:American journal of physical anthropology
pub_type: 杂志文章
doi:10.1002/ajpa.23343
更新日期:2018-02-01 00:00:00
abstract::It is now known that several population movements have taken place at different times throughout southern Arabian prehistory. One of the principal questions under debate is if the Early Holocene peopling of southern Arabia was mainly due to input from the Levant during the Pre-Pottery Neolithic B, to the expansion of ...
journal_title:American journal of physical anthropology
pub_type: 杂志文章
doi:10.1002/ajpa.22131
更新日期:2012-10-01 00:00:00
abstract::The Miles method of age estimation relies on molar wear to estimate age and is widely used in bioarcheological contexts. However, because the method requires physical seriation and a sample of subadults to estimate wear rates it cannot be applied to many samples. Here, we modify the Miles method by scoring occlusal we...
journal_title:American journal of physical anthropology
pub_type: 杂志文章
doi:10.1002/ajpa.22106
更新日期:2012-10-01 00:00:00
abstract:OBJECTIVES:This research theoretically models and empirically records symphyseal surface strain during in vitro human mandibular wishboning (lateral transverse bending) in order to test one aspect of the hypothesis that the chin is an adaptive response to masticatory stresses. From a perspective of optimality, three qu...
journal_title:American journal of physical anthropology
pub_type: 杂志文章
doi:10.1002/ajpa.22863
更新日期:2016-02-01 00:00:00
abstract::An intergroup comparison of cephalometric landmark configurations by the finite-element method elegantly depicts the algebra of some of the size and shape change measures that one may define by reference to those landmarks. In studies of mean differences between groups, the statistical analysis of these finite element...
journal_title:American journal of physical anthropology
pub_type: 杂志文章
doi:10.1002/ajpa.1330740408
更新日期:1987-12-01 00:00:00
abstract::Fluctuating asymmetry (FA) is thought to increase as a result of environmental perturbations during development. A number of studies involving measures of health and developmental stability other than FA have discussed the presumed increased buffering in females relative to males. But, there is little evidence in the ...
journal_title:American journal of physical anthropology
pub_type: 杂志文章
doi:10.1002/ajpa.21357
更新日期:2010-10-01 00:00:00
abstract::This paper describes the skeletal maturity status of Japanese children in Western Kyushu and its variation within Japanese populations. Hand-wrist skeletal maturity was assessed by the Tanner-Whitehouse (1975) (TW2) method from radiographs of 500 boys and 485 girls aged from 4 to 15 years. Western Kyushu children show...
journal_title:American journal of physical anthropology
pub_type: 杂志文章
doi:10.1002/ajpa.1330620209
更新日期:1983-10-01 00:00:00
abstract::With the development of computed tomography, soft tissues and foreign body collections are distinguished with remarkable resolution. This distinction is particularly useful when examining desiccated human remains, both in construction of research strategies and when invasive procedure (i.e., traditional autopsies, nee...
journal_title:American journal of physical anthropology
pub_type: 历史文章,杂志文章
doi:10.1002/ajpa.1330550114
更新日期:1981-05-01 00:00:00
abstract::I analyzed the finger prints of 59 male and 48 female unrelated Bengalis in a rehabilitation camp of Dacca, Bangladesh. The most common pattern type in the Bengalis was the ulnar loop (53%), then whorls (40%); arches (5%) and radial loops (2%) were the least common. Radial loops occurred most frequently on the index f...
journal_title:American journal of physical anthropology
pub_type: 杂志文章
doi:10.1002/ajpa.1330500215
更新日期:1979-02-01 00:00:00
abstract:OBJECTIVES:The use of dental metrics in phylogenetic reconstructions of fossil primates assumes variation in tooth size is highly heritable. Quantitative genetic studies in humans and baboons have estimated high heritabilities for dental traits, providing a preliminary view of the variability of dental trait heritabili...
journal_title:American journal of physical anthropology
pub_type: 杂志文章
doi:10.1002/ajpa.23744
更新日期:2019-02-01 00:00:00
abstract::Catarrhine symphyseal morphology displays considerable variation. Although this has been related to dentition, phylogeny, sexual dimorphism, and facial orientation, most emphasis has been given to the functional significance of the symphysis to mechanical loading during mastication. The current state of knowledge rega...
journal_title:American journal of physical anthropology
pub_type: 杂志文章
doi:10.1002/ajpa.21573
更新日期:2011-10-01 00:00:00
abstract::Patterns of water consumption by past human populations are rarely considered, yet drinking behavior is socially mediated and access to water sources is often socially controlled. Oxygen isotope analysis of archeological human remains is commonly used to identify migrants in the archeological record, but it can also b...
journal_title:American journal of physical anthropology
pub_type: 历史文章,杂志文章
doi:10.1002/ajpa.22544
更新日期:2014-08-01 00:00:00
abstract::Pliopithecid remains from the Spanish locality of Torrent de Febulines (Late Vallesian, MN 10), consisting of right and left mandibular fragments with partial tooth rows and an isolated P(3) probably belonging to the same individual, are described and assigned to Egarapithecus narcisoi gen. et sp. nov. (Pliopithecidae...
journal_title:American journal of physical anthropology
pub_type: 杂志文章
doi:10.1002/ajpa.1043
更新日期:2001-04-01 00:00:00
abstract::Cases of pathologically changed bone might constitute a diagnostic pitfall and frequently need histological methods to be etiologically properly evaluated. With micro-computed tomography (microCT), a new epoch of 2D and 3D imaging has been launched. We evaluated the diagnostic investigation of this analytical method v...
journal_title:American journal of physical anthropology
pub_type: 历史文章,杂志文章
doi:10.1002/ajpa.20611
更新日期:2007-08-01 00:00:00
abstract:OBJECTIVES:To infer the ecogeographic conditions that underlie the evolutionary diversification of macaques, we investigated the within- and between-species relationships of craniodental dimensions, geography, and environment in extant macaque species. We studied evolutionary processes by contrasting macroevolutionary ...
journal_title:American journal of physical anthropology
pub_type: 杂志文章
doi:10.1002/ajpa.23439
更新日期:2018-06-01 00:00:00
abstract::Geographic information systems (GIS) software is typically used for analyzing geographically distributed data, allowing users to annotate points or areas on a map and attach data for spatial analyses. While traditional GIS-based research involves geo-referenced data (points tied to geographic locations), the use of th...
journal_title:American journal of physical anthropology
pub_type: 杂志文章
doi:10.1002/ajpa.22099
更新日期:2012-08-01 00:00:00
abstract::Past studies have shown a consistent association of a specific set of mitochondrial DNA 9 base pair (bp) deletion haplotypes with Polynesians and their Austronesian-speaking relatives, and the total lack of the deletion in a short series of New Guinea Highlanders. Utilizing plasma and DNA samples from various old labo...
journal_title:American journal of physical anthropology
pub_type: 杂志文章
doi:10.1002/(SICI)1096-8644(199911)110:3<243::AID-AJPA
更新日期:1999-11-01 00:00:00
abstract::Paget's disease has been ascribed several times to specimens of archeological bone but, in the absence of microscopic examination, the evidence remains insubstantial. Suspected metabolic bone disease is described here in the archeological remains of a skeleton from a 16th century burial ground at Wells Cathedral, Engl...
journal_title:American journal of physical anthropology
pub_type: 历史文章,杂志文章
doi:10.1002/ajpa.1330890306
更新日期:1992-11-01 00:00:00
abstract::We examine the demographic correlates of paternity confidence, or men's assessment of the likelihood that they are the genetic father of a particular child. Evolutionary theory predicts that men will provide less parental investment for putative genetic offspring who are unlikely to be their actual offspring, but conf...
journal_title:American journal of physical anthropology
pub_type: 杂志文章
doi:10.1002/ajpa.20452
更新日期:2006-12-01 00:00:00
abstract::This paper present the content of the Musée de l'Homme exhibition "Us and them: from prejudice to racism" and provides a detailed explanation of how this content has been presented to the public. In a second section of this paper we explain some of the analysis and concepts, from a biological anthropology perspective,...
journal_title:American journal of physical anthropology
pub_type: 杂志文章
doi:10.1002/ajpa.24158
更新日期:2020-10-18 00:00:00
abstract::Human skeletal robusticity is influenced by a number of factors, including habitual behavior, climate, and physique. Conflicting evidence as to the relative importance of these factors complicates our ability to interpret variation in robusticity in the past. It remains unclear how the pattern of robusticity in the sk...
journal_title:American journal of physical anthropology
pub_type: 历史文章,杂志文章
doi:10.1002/ajpa.20398
更新日期:2006-10-01 00:00:00
abstract::The geometry of the midshaft cross-sections of the femur and humerus of five indriid species was analysed. Internal (marrow cavity) and external diameters were measured on X-rays in the anteroposterior (a-p) and mediolateral (m-l) planes; cross-sectional areas, second moments of area, and section moduli were calculate...
journal_title:American journal of physical anthropology
pub_type: 杂志文章
doi:10.1002/ajpa.1330860409
更新日期:1991-12-01 00:00:00
abstract::Haplogroup R1a1-M198 is a major clade of Y chromosomal haplogroups which is distributed all across Eurasia. To this date, many efforts have been made to identify large SNP-based subgroups and migration patterns of this haplogroup. The origin and spread of R1a1 chromosomes in Eurasia has, however, remained unknown due ...
journal_title:American journal of physical anthropology
pub_type: 杂志文章
doi:10.1002/ajpa.22167
更新日期:2012-12-01 00:00:00