Abstract：
:Nephrotoxicity of cadmium (Cd) was investigated using puromycin aminonucleoside (AN)-pretreated rats. AN pretreatment was performed by iv injection of 100 mg AN/kg body wt 11 days before the initial Cd injection. Since massive proteinuria and focal glomerular deposits were recognized, glomerular permeability is considered to be increased in AN-pretreated rats. AN-pretreated and intact rats were injected sc with 3 mg Cd/kg body wt, 4 times a week. In non-pretreated rats, slight tubular vacuolation was seen after 1-week Cd exposure and severe vacuolation and coagulative necrosis of the tubules was observed after 2-week Cd exposure. On the other hand, AN pretreatment delayed the onset of vacuolation and necrosis for 1 week and made the lesion milder. After 1-week Cd exposure, a larger amount of Cd was excreted into the urine of AN-pretreated rats than of non-pretreated ones, whereas Cd accumulation in the kidney and liver was lower in AN-pretreated rats than in non-pretreated ones. Thereafter, no difference in Cd concentration was recognized between two groups. From these findings, it is suggested that in early stage of Cd administration, Cd was filtered through the glomerular basement membrane modified by AN pretreatment and that this filterable Cd did not have nephrotoxic effects in AN-pretreated rats.
journal_name
Environ Resjournal_title
Environmental researchauthors
Yamada YK,Shimizu F,Suzuki KT,Yamamura M,Kubota Kdoi
10.1016/0013-9351(83)90204-9subject
Has Abstractpub_date
1983-10-01 00:00:00pages
179-87issue
1eissn
0013-9351issn
1096-0953pii
0013-9351(83)90204-9journal_volume
32pub_type
杂志文章abstract：:Effects of fine volcanic ash aerosol on pulmonary mechanical properties of awake guinea pigs were evaluated during exposure by inhalation. Ash penetration into the lung as well as tissue response to ash were determined by transmission electron microscopy. The reactivity of airway epithelial irritant receptors followin...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/0013-9351(85)90020-9
更新日期：1985-02-01 00:00:00
abstract：OBJECTIVES:To investigate the association between short-term changes in ambient pollution (particulate matter <2.5 μm in aerodynamic diameter (PM2.5) and ozone (O3)) and the risk of ischemic stroke among individuals living in a bi-ethnic community and whether this association is modified by ethnicity. METHODS:We ident...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2015.09.031
更新日期：2015-11-01 00:00:00
abstract：:Athens is a city with a serious air pollution problem which has existed for more than 20 years. To evaluate whether air pollution has affected lung cancer incidence (and hence, mortality) in the population of Athens we have compared standardized lung mortality between Athens and the rest of Greece taking into account ...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/s0013-9351(87)80225-6
更新日期：1987-12-01 00:00:00
abstract：:Urban renewal efforts are a priority for many American cities. As efforts to reconstitute urban centers increase, the demolition of old, deteriorated structures has accelerated. Recent studies have identified demolitions as a potential source of environmental lead exposure. We conducted a study examining the relations...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2006.09.011
更新日期：2007-03-01 00:00:00
abstract：:Although the anti-knocking agents used in Taiwan do not contain manganese, there are relatively high concentrations of the element in diesel fuel. As such, there have been many concerns about the impact of exposure to diesel fuels on health. This study was conducted in Taiwan to investigate the relationship between th...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2011.01.001
更新日期：2011-02-01 00:00:00
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journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/s0013-9351(88)80056-2
更新日期：1988-06-01 00:00:00
abstract：:Based on 1677 published studies, 1648 sites across China collected from 1985 to 2016 were used to research the concentrations of arsenic in agricultural soils. In order to understand the status of arsenic pollution in agricultural soils in China over the past three decades, and to learn about the arsenic stocks in agr...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2020.109525
更新日期：2020-07-01 00:00:00
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journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2011.07.011
更新日期：2011-11-01 00:00:00
abstract：:The increased nitrogen (N) fertilizer usage caused substantial nitrate (NO3-) leaching into groundwater and eutrophication in downstream aquatic systems. Riparian zones positioned as the link interfaces of terrestrial and aquatic environments are effective in NO3- removal. However, the microbial mechanisms regulating ...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2019.108867
更新日期：2020-01-01 00:00:00
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journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2012.09.003
更新日期：2013-01-01 00:00:00
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journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2008.07.003
更新日期：2008-11-01 00:00:00
abstract：:Production of biochar from sewage sludge (SS) is consistent with the goal of sustainable resource recovery and promotes a wastewater-based circular economy. Thermochemical conversion of SS to biochar resolves two major issues simultaneously as it minimizes the cost of disposal and acts as a resource to eliminate the t...
journal_title：Environmental research
pub_type： 杂志文章,评审
doi：10.1016/j.envres.2020.110656
更新日期：2021-01-05 00:00:00
abstract：BACKGROUND:Physical inactivity is a major public health concern. Natural, or semi-natural, environments may encourage physical activity, but the influences of socio-economic factors have been under-researched. METHODS:We explored the associations between meeting physical activity (PA) guidelines and both neighbourhood...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2020.109899
更新日期：2020-11-01 00:00:00
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journal_title：Environmental research
pub_type： 杂志文章,评审
doi：10.1016/j.envres.2017.11.010
更新日期：2018-02-01 00:00:00
abstract：:The present study assessed the protective effect of chitosan-nanoencapsulated quercetin (Qu-ChiNPs) against oxidative stress caused by silver nanoparticles (AgNPs). To this end, the transcription of prime genes regulating hepatic Keap1-Nrf2 pathway as well as downstream antioxidant enzymes were monitored prior to and ...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2020.109477
更新日期：2020-06-01 00:00:00
abstract：:Concerns regarding the release of microplastics (MPs) into the environment led us to explore the relationship between the different environmental factors and physicochemical properties of MPs, as well as the change of interaction between MPs and organic pollutants. In this study, the effects of environmental factors (...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2018.06.034
更新日期：2018-10-01 00:00:00
abstract：:Relatively little attention has been devoted to the risks from mercury in saltwater fish, that were caught by recreational fisherfolk. Although the US Food and Drug Administration has issued advisories based on mercury for four saltwater species or groups of fish, there are few data on how mercury levels vary by size,...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2009.07.005
更新日期：2009-10-01 00:00:00
abstract：BACKGROUND:Effects of prenatal Manganese (Mn) exposure at an environmental relevant level on neonatal neurodevelopment remains unclear. OBJECTIVES:In the multi-center study, we assessed the impact of low level prenatal Mn exposure on neonatal behavioral neurological assessments (NBNA), and explore a threshold umbilica...
journal_title：Environmental research
pub_type： 杂志文章,多中心研究
doi：10.1016/j.envres.2014.04.012
更新日期：2014-08-01 00:00:00
abstract：:Exposure to metals, specifically cadmium, lead, and mercury, is widespread and is associated with reduced bone mineral density (BMD) in older populations, but the associations among premenopausal women are unclear. Therefore, we evaluated the relationship between these metals in blood and BMD (whole body, total hip, l...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2012.06.001
更新日期：2013-01-01 00:00:00
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journal_title：Environmental research
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.envres.2018.02.030
更新日期：2018-07-01 00:00:00
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journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2020.110064
更新日期：2020-12-01 00:00:00
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journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2015.07.019
更新日期：2015-10-01 00:00:00
abstract：:Continuous air quality monitoring in the Vojvodina district of Serbia and Montenegro has shown high levels of Cd, especially in the outskirts of large towns such as Kikinda. The construction and metal processing industries located in Kikinda have been emitting significant amounts of heavy metals into the environment. ...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2004.05.008
更新日期：2005-01-01 00:00:00
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journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2015.03.031
更新日期：2015-07-01 00:00:00
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journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2019.02.047
更新日期：2019-05-01 00:00:00
abstract：:Cytogenetic investigations were carried out on 50 workers exposed to stone dust in a stone crusher industry and on 25 control subjects never exposed to such dust. The frequency of chromosomal aberrations and sister chromatid exchanges in exposed individuals was significantly higher than that in controls (P less than 0...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/s0013-9351(05)80106-9
更新日期：1991-10-01 00:00:00
abstract：:Effects of multiple pollutants including heavy metal on oxidative stress indices were measured in leaves and roots of Avicennia alba Blume. collected from three coastal locations in Kerala-Cochin, Kollam and Chetua. We observed significant activities in lipid peroxidation, root oxidizability, electrolyte leakage and a...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2011.07.002
更新日期：2011-11-01 00:00:00
abstract：:The loggerhead turtle (Caretta caretta) can be considered a good indicator species for studying the ecological impact of endocrine disrupting chemicals (EDCs) on wildlife. However, the effect of these environmental pollutants on nuclear steroid hormone signaling has not yet been addressed in sea turtles mainly due to ...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/j.envres.2017.07.024
更新日期：2017-10-01 00:00:00
abstract：:When rats were exposed to 10 ppm NO2 for 7 days, the succinate-cytochrome c reductase activity, the rate-limiting step of mitochondrial succinoxidase, of the liver decreased progressively, reaching 77% (P less than 0.01) of the control level by the fifth day. By contrast, this activity was gradually increased by a 10-...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1016/0013-9351(84)90004-5
更新日期：1984-02-01 00:00:00
abstract：:Chronic exposure and postexposure experiments have been recently performed in rats to evaluate the biological responses of inhaled refractory ceramic fibers (RCF) at different concentration levels. The lung burden data in the accessory lobe of the rat lung were collected during and after different exposure and postexp...
journal_title：Environmental research
pub_type： 杂志文章
doi：10.1006/enrs.1994.1035
更新日期：1994-05-01 00:00:00
