Abstract：
BACKGROUND:Effects of prenatal Manganese (Mn) exposure at an environmental relevant level on neonatal neurodevelopment remains unclear. OBJECTIVES:In the multi-center study, we assessed the impact of low level prenatal Mn exposure on neonatal behavioral neurological assessments (NBNA), and explore a threshold umbilical cord blood Mn on neonatal neurological development. METHODS:We investigated 933 mother-newborn pairs in Shanghai, China, from 2008 through 2009. Umbilical cord serum concentrations of Mn were measured and NBNA tests were conducted. The NBNA contains five clusters: behavior, active tone, passive tone, primary reflexes and general assessment with a maximal total score of 40. The score<37 is defined as low. RESULTS:The median serum Mn concentration was 4.0 μg/L. Of the 933 infants, 44 (4.7%) had low NBNA. After adjusting for potential confounders, a high level of Mn (≥ 75th percentile ) was associated with a lower NBNA score (adjusted ß=-1.1, 95% CI: -1.4-0.7, p<0.01) and a higher risk of low NBNA (adjusted OR=9.4, 95% CI: 3.4-25.7, p<0.01). A nonlinear relationship was observed between cord serum Mn and NBNA after adjusting for potential confounders. NBNA score decreased with increasing Mn levels after 5.0 μg/L(LgMn ≥ 0.7). The cord serum Mn ≥ 5.0 μg/L had adverse effects on behavior, active tone and general reactions of clusters (p<0.001). CONCLUSIONS:High prenatal Mn exposure even at an environmental relevant level, is associated with poor fetal neurobehavioral development in a nonlinear pattern. A threshold cord serum Mn of 5.0 μg/L existed for lower neonatal behavioral neurological assessments.
journal_name
Environ Resjournal_title
Environmental researchauthors
Yu XD,Zhang J,Yan CH,Shen XMdoi
10.1016/j.envres.2014.04.012subject
Has Abstractpub_date
2014-08-01 00:00:00pages
232-8eissn
0013-9351issn
1096-0953pii
S0013-9351(14)00103-0journal_volume
133pub_type
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