Toxicity of isopropyl alcohol exposure on the nasal mucociliary system in the guinea pig.

Abstract:

:The toxicity of isopropyl alcohol (IPA) on the nasal mucosa in the guinea pig was experimentally studied, with special reference to the recovery process of the organ. The results showed that 400 ppm of IPA has an acute effect on the nasal mucosa and the recovery from such degeneration can occur in 2 weeks. When functional and morphological damages were induced by a higher level (5500 ppm) of IPA, it took over 2 weeks for complete recovery from such damage. The conclusion is that the present allowable level of IPA is reasonable from a viewpoint of the effect of short-term exposure to IPA on the nasal mucosa. In addition, a higher level of IPA exposure has a longer-term effect on the nasal mucociliary system in the guinea pig, and workers exposed to such a higher level of IPA should be given careful otolaryngological observation.

journal_name

Environ Res

journal_title

Environmental research

authors

Ohashi Y,Nakai Y,Koshimo H,Esaki Y,Ikeoka H,Horiguchi S,Teramoto K,Nakaseko H

doi

10.1016/s0013-9351(88)80056-2

subject

Has Abstract

pub_date

1988-06-01 00:00:00

pages

25-38

issue

1

eissn

0013-9351

issn

1096-0953

pii

S0013-9351(88)80056-2

journal_volume

46

pub_type

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