Cue exposure therapy for the treatment of opiate addiction: results of a randomized controlled clinical trial.

Abstract:

BACKGROUND:Persistent cue reactivity to drug-related stimuli is a well-known phenomenon among abstinent drug users and has been found to be a predictor of relapse. Cue exposure therapy (CET) aims to reduce this cue reactivity by exposing abstinent drug users to conditioned drug-related stimuli while preventing their habitual response, i.e. drug use. METHODS:127 abstinent heroin-dependent Dutch inpatients were randomized to CET (n = 65; 55 completers) and placebo psychotherapy treatment (PPT) (n = 62; 59 completers). It was examined whether CET would lead to a decrease in drug-related cue reactivity (using mixed-design ANOVA) and subsequently to lower dropout and relapse rates (using logistic regression) compared to PPT. RESULTS:Both groups responded with a similar decrease in self-reported cue reactivity (craving, mood). The CET group did show a significant decrease in physiological reactivity (skin conductance) compared to PPT. However, dropout and relapse rates were, contrary to our expectations, significantly higher in the CET group. CONCLUSIONS:This is the first randomized controlled trial showing that CET, compared to a non-specific psychotherapy, might increase dropout and relapse rates among abstinent heroin-dependent clients in a drug-free setting. Caution is warranted when applying CET in this specific context.

journal_name

Psychother Psychosom

authors

Marissen MA,Franken IH,Blanken P,van den Brink W,Hendriks VM

doi

10.1159/000097968

subject

Has Abstract

pub_date

2007-01-01 00:00:00

pages

97-105

issue

2

eissn

0033-3190

issn

1423-0348

pii

000097968

journal_volume

76

pub_type

杂志文章,随机对照试验
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    doi:10.1159/000288873

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    doi:10.1159/000287458

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    pub_type: 杂志文章

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  • Denial in heart transplant candidates.

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    pub_type: 杂志文章

    doi:10.1159/000288421

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    doi:10.1159/000288048

    authors: Dippel B,Lauer C,Riemann D,Majer-Trendel K,Krieg JC,Berger M

    更新日期:1987-01-01 00:00:00

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    pub_type: 杂志文章

    doi:10.1159/000288987

    authors: Petterson IL,Arnetz BB,Arnetz JE,Hörte LG

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    pub_type: 杂志文章

    doi:10.1159/000287992

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    更新日期:1987-01-01 00:00:00

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    pub_type: 杂志文章

    doi:10.1159/000287850

    authors: Husby R,Dahl AA,Dahl CI,Heiberg AN,Olafsen OM,Weisaeth L

    更新日期:1985-01-01 00:00:00

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    pub_type: 杂志文章

    doi:10.1159/000288149

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    更新日期:1989-01-01 00:00:00

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    pub_type: 临床试验,杂志文章,随机对照试验

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    authors: Goldberg RJ,Wool MS

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    authors: Cosgrove L,Krimsky S,Vijayaraghavan M,Schneider L

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    doi:10.1159/000289088

    authors: Matsubayashi S,Tamaí H,Matsumoto Y,Tamagawa K,Mukuta T,Morita T,Kubo C

    更新日期:1996-01-01 00:00:00

  • Psychosomatic aspects in self-help groups made up of medical patients. Presented on the example of the ostomy group.

    abstract::We present the psychosomatic aspects in self-help groups containing medical patients on the examples of the ostomy group. Following the demonstration of the psychodynamic group processes, the patients' psychological characteristics are described as well as the aims of this type of self-help group. The specific ostomy ...

    journal_title:Psychotherapy and psychosomatics

    pub_type: 杂志文章

    doi:10.1159/000287321

    authors: Freyberger H

    更新日期:1979-01-01 00:00:00

  • Explicit incestuous motifs and emotional crises in psychosomatic patients.

    abstract::This paper examines the emergence of incestuous motifs in the first four interviews of 50 people seeking psychotherapy. Results show a percentage (6%) which is neither relevant nor specific for any kind of diagnosis. The progress in psychotherapy of two groups of 8 patients, psychosomatic + neurotic respectively, is t...

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    pub_type: 杂志文章

    doi:10.1159/000287790

    authors: Pasini A,Callea G

    更新日期:1984-01-01 00:00:00

  • Language acquisition in relation to cumulative posttraumatic stress disorder symptom load over time in a sample of re-settled refugees.

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    journal_title:Psychotherapy and psychosomatics

    pub_type: 杂志文章

    doi:10.1159/000078849

    authors: Söndergaard HP,Theorell T

    更新日期:2004-09-01 00:00:00

  • Patients' fantasies about physical illness.

    abstract::All patients with physical illness have an underlying fantasy concerning why they became sick. This fantasy can be elicited by the consulting psychiatrist and the treating physician. The meaning of the fantasy is consistent with the psychodynamic theory of human behavior. Also, once the fantasy is understood, it can b...

    journal_title:Psychotherapy and psychosomatics

    pub_type: 杂志文章

    doi:10.1159/000287738

    authors: Blumenfield M

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  • Borderlines: problems of self and object separation.

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    pub_type: 杂志文章

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    authors: Leibovich MA

    更新日期:1976-01-01 00:00:00

  • Short-term psychotherapy and hypnosis.

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    pub_type: 杂志文章

    doi:10.1159/000287509

    authors: Frankel FH

    更新日期:1981-01-01 00:00:00

  • Life events and alopecia areata.

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    pub_type: 杂志文章

    doi:10.1159/000287786

    authors: Perini GI,Veller Fornasa C,Cipriani R,Bettin A,Zecchino F,Peserico A

    更新日期:1984-01-01 00:00:00

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    pub_type: 杂志文章

    doi:10.1159/000288103

    authors: Engel K,Fuchs M,Meier I,Deneke F

    更新日期:1988-01-01 00:00:00

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    pub_type: 杂志文章,随机对照试验

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    authors: Ducasse D,Jaussent I,Arpon-Brand V,Vienot M,Laglaoui C,Béziat S,Calati R,Carrière I,Guillaume S,Courtet P,Olié E

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    pub_type: 杂志文章

    doi:10.1159/000512843

    authors: Wahlund T,Mataix-Cols D,Olofsdotter Lauri K,de Schipper E,Ljótsson B,Aspvall K,Andersson E

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    pub_type: 杂志文章,随机对照试验

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