Abstract:
:The lungs of BR6 breeding female mice which had developed spontaneous mammary tumours, were examined histologically for the presence of metastases. Metastatic nodules, or tumour cell emboli within blood vessels, were found in the lungs of 3 out of 42 (7 per cent) mice with pregnancy-dependent tumours, and in 33 out of 117 (28 per cent) mice with pregnancy-independent tumours. In general, primary tumours which were well-differentiated and organized were less likely to metastasize than poorly-differentiated ones, but there was an intermediate range within which the likelihood of metastasis could not be predicted. Analysis of the reproductive histories of the mice did not show any significant correlations between factors which might have influenced the growth and progression of the primary tumour and metastatic potential. However, the sustained presence of a high tumour load was associated with an increased probability of metastasis.
journal_name
Clin Exp Metastasisjournal_title
Clinical & experimental metastasisauthors
Lee AE,Pang LS,Rogers LA,Jeffery REdoi
10.1007/BF00736406subject
Has Abstractpub_date
1983-07-01 00:00:00pages
223-7issue
3eissn
0262-0898issn
1573-7276journal_volume
1pub_type
杂志文章abstract::The purpose of this study was to determine the subpopulation dynamics of human colon carcinoma (HCC) cells growing at orthotopic (cecum, liver) or ectopic (subcutis, kidney, spleen) sites in nude mice and to correlate any outgrowth of distinct clones with the differential expression of metastasis-related genes. Low me...
journal_title:Clinical & experimental metastasis
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journal_title:Clinical & experimental metastasis
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journal_title:Clinical & experimental metastasis
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journal_title:Clinical & experimental metastasis
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journal_title:Clinical & experimental metastasis
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journal_title:Clinical & experimental metastasis
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journal_title:Clinical & experimental metastasis
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journal_title:Clinical & experimental metastasis
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更新日期:2000-01-01 00:00:00
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journal_title:Clinical & experimental metastasis
pub_type: 杂志文章
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更新日期:1999-03-01 00:00:00
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journal_title:Clinical & experimental metastasis
pub_type: 杂志文章
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更新日期:1997-11-01 00:00:00
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journal_title:Clinical & experimental metastasis
pub_type: 杂志文章
doi:10.1007/BF00058058
更新日期:1987-04-01 00:00:00
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journal_title:Clinical & experimental metastasis
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更新日期:2010-10-01 00:00:00
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journal_title:Clinical & experimental metastasis
pub_type: 杂志文章
doi:10.1007/s10585-007-9126-2
更新日期:2008-01-01 00:00:00
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journal_title:Clinical & experimental metastasis
pub_type: 杂志文章,评审
doi:10.1023/a:1021379811308
更新日期:2002-01-01 00:00:00
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journal_title:Clinical & experimental metastasis
pub_type: 杂志文章
doi:10.1007/BF00121912
更新日期:1995-09-01 00:00:00
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journal_title:Clinical & experimental metastasis
pub_type: 杂志文章
doi:10.1007/s10585-008-9231-x
更新日期:2009-01-01 00:00:00
abstract::Matrilysin is a member of the matrix metalloproteinase gene family which is believed to play an important role in tumor progression. Expression of matrilysin mRNA was examined by reverse transcription-polymerase chain reaction combined with Southern blot analysis in 46 human primary gastric cancers. Overexpression of ...
journal_title:Clinical & experimental metastasis
pub_type: 杂志文章
doi:10.1023/a:1006509312674
更新日期:1998-05-01 00:00:00
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journal_title:Clinical & experimental metastasis
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journal_title:Clinical & experimental metastasis
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更新日期:2002-01-01 00:00:00
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journal_title:Clinical & experimental metastasis
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更新日期:2002-01-01 00:00:00
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journal_title:Clinical & experimental metastasis
pub_type: 杂志文章
doi:10.1023/a:1020392309715
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journal_title:Clinical & experimental metastasis
pub_type: 杂志文章
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更新日期:2020-04-01 00:00:00
abstract::Anti-resorptive bisphosphonates (BPs) have been clinically used to prevent cancer-bone metastasis and cancer-induced bone pathologies despite the fact that the phenotypic response of the cancer-bone interactions to BP exposure is "uncharted territory". This study offers unique insights into the interplay between cance...
journal_title:Clinical & experimental metastasis
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更新日期:2016-08-01 00:00:00
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journal_title:Clinical & experimental metastasis
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更新日期:2005-01-01 00:00:00
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journal_title:Clinical & experimental metastasis
pub_type: 杂志文章
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更新日期:2020-04-01 00:00:00
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journal_title:Clinical & experimental metastasis
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journal_title:Clinical & experimental metastasis
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更新日期:2009-01-01 00:00:00