Toxic effects of acid rain on aquatic and terrestrial ecosystems.

abstract：:Thymic stromal lymphopoietin (TSLP) was reported to induce mast cell proliferation and aggravate allergic reactions through activation of mouse double minute 2 (MDM2). We aimed to ascertain that β-sitosterol (SI), which is one of the several phytosterols found mostly in foods, would regulate TSLP-induced mast cell pro...

journal_title：Canadian journal of physiology and pharmacology

authors： Han NR,Kim HM,Jeong HJ

更新日期：2015-11-01 00:00:00

abstract：:The effects of Bay K8644, a Ca2+ channel agonist, on the mechanical and electrical properties of frog skeletal muscle fibers were investigated. At relatively low concentrations, such as 10(-6) and 10(-5) M, Bay K8644 significantly potentiated the maximum amplitudes of twitch responses, and this effect was not reversed...

journal_title：Canadian journal of physiology and pharmacology

authors： Oz M,Frank GB

更新日期：1994-10-01 00:00:00

abstract：:This study investigated the potential of shikonin as an anticancer agent against liver cancer and an in vitro human hepatoma cancer model system. The HepG2 cell line was the hepatoma cancer model in the present study. The inhibitory effect of shikonin on the growth of HepG2 cells was measured by MTT assay. To explore ...

journal_title：Canadian journal of physiology and pharmacology

authors： Yingkun N,Lvsong Z,Huimin Y

更新日期：2010-12-01 00:00:00

abstract：:Animals treated with nitric oxide synthase (NOS) inhibitors exhibit marked hypersensitivity to the blood pressure lowering effects of exogenous nitric oxide (NO) donors. We used this model as a sensitive index to evaluate the relative importance of reduced biotransformation of glyceryl trinitrate (GTN) to NO in the de...

journal_title：Canadian journal of physiology and pharmacology

authors： Ratz JD,Adams MA,Bennett BM

更新日期：2002-11-01 00:00:00

abstract：:The mechanisms of the positive inotropic action of a new synthetic tetrahydroisoquinoline compound, SL-1, were investigated in isolated rat cardiac tissues and ventricular myocytes. SL-1 produced a rapidly developing, concentration-dependent positive inotropic response in both atrial and ventricular muscles and a nega...

journal_title：Canadian journal of physiology and pharmacology

authors： Chang GJ,SU MJ,Lee PH,Lee SS,Liu KC

更新日期：1995-11-01 00:00:00

abstract：:To determine the effects of chronic hyperinsulinemia on glucagon release, rats were made hyperinsulinemic for 14 days by supplementation of drinking water with sucrose (10%; sucrose-fed) to increase endogenous release or by implantation of osmotic minipumps (subcutaneous, s.c.; or intraperitoneal, i.p.) to deliver exo...

journal_title：Canadian journal of physiology and pharmacology

authors： Brubaker PL,Kazumi T,Hirano T,Vranic M,Steiner G

更新日期：1991-03-01 00:00:00

abstract：:Serotonin (5-HT) acts as a neuromodulator and plays a critical role in brain development. Changes in 5-HT signaling during the perinatal period can affect neural development and may result in behavioral changes in adulthood. However, further investigations are necessary including both sexes to study possible differenc...

journal_title：Canadian journal of physiology and pharmacology

authors： Campos RMM,Toscano AE,Gouveia HJCB,Lacerda DC,Pereira SDC,Paz IAASG,Dantas-Alves JS,Manhaes-de-Castro R

更新日期：2020-09-17 00:00:00

abstract：:This paper presents data showing that the sympathetic autonomic areas of the cat thoracolumbar spinal cord contain nerve terminals and fibres with immunoreactivity for at least seven neuropeptides. The distribution in the intermediolateral cell column of the terminals and fibres which contain enkephalin-, neuropeptide...

journal_title：Canadian journal of physiology and pharmacology

authors： Krukoff TL

更新日期：1987-08-01 00:00:00

abstract：:The present study was conducted to evaluate the local antinociceptive actions of fluoxetine, a selective serotonin reuptake inhibitor, and the possible involvement of the l-arginine/NO/cGMP/KATP channel pathway in this effect using the formalin test in rats. To elucidate the underlying mechanisms, animals were pre-tre...

journal_title：Canadian journal of physiology and pharmacology

authors： Ghorbanzadeh B,Mansouri MT,Naghizadeh B,Alboghobeish S

更新日期：2018-02-01 00:00:00

abstract：:Changes in metabolic characteristics of the liver and jejunal epithelia as a result of feeding the beta-agonist albuterol to chickens for 3 and 6 weeks were studied. Feeding albuterol resulted in a change in weights of the liver and small intestines. Chickens fed albuterol for 6 weeks had greater levels of plasma none...

journal_title：Canadian journal of physiology and pharmacology

authors： Rompala RE,Darre MJ

更新日期：1989-05-01 00:00:00

abstract：:In the present study we characterized the receptor(s) that mediates non-adrenergic non-cholinergic (NANC) contractions of isolated guinea pig cervical trachea, using CP-99,994, a selective neurokinin (NK1) receptor antagonist, and SR-48,968, a selective neurokinin (NK2) receptor antagonist. The activity of these two a...

journal_title：Canadian journal of physiology and pharmacology

authors： Charette L,Foulon D,Rodger IW,Jones TR

更新日期：1994-02-01 00:00:00

abstract：:Diazinon (DZN) is a common organophosphorus insecticide extensively used for agriculture and veterinary purposes. DZN toxicity is not limited to insects; it also induces harmful effects in mammals and birds. Our experiment evaluated the protective and antioxidant potential of sesame oil (SO) and (or) alpha-lipoic acid...

journal_title：Canadian journal of physiology and pharmacology

authors： Abdel-Daim MM,Taha R,Ghazy EW,El-Sayed YS

更新日期：2016-01-01 00:00:00

abstract：:The beneficial hypolipidemic and antioxidant influences of the dietary spice compounds curcumin and capsaicin were evaluated. Curcumin, capsaicin, or their combination were included in the diet of high-(30%)-fat-fed rats for 8 weeks. Dietary high-fat-induced hypertriglyceridemia was countered by dietary curcumin, caps...

journal_title：Canadian journal of physiology and pharmacology

authors： Manjunatha H,Srinivasan K

更新日期：2007-06-01 00:00:00

abstract：:Atherosclerosis is a chronic inflammatory disease resulting in the formation of the atherosclerotic plaque. Plaque formation starts with the inflammation in fatty streaks and progresses through atheroma, atheromatous plaque, and fibroatheroma leading to development of stable plaque. Hypercholesterolemia, dyslipidemia,...

journal_title：Canadian journal of physiology and pharmacology

authors： Rai V,Agrawal DK

更新日期：2017-10-01 00:00:00

abstract：:Muramyl peptides derived from bacterial peptidoglycan are detected intracellularly by Nod1 and Nod2, 2 members of the newly characterized nod-like receptor (NLR) family of pattern recognition molecules. In the absence of bacterial invasion into the host cytosolic compartment, it remains unclear whether muramyl peptide...

journal_title：Canadian journal of physiology and pharmacology

authors： Ismair MG,Vavricka SR,Kullak-Ublick GA,Fried M,Mengin-Lecreulx D,Girardin SE

更新日期：2006-12-01 00:00:00

abstract：:Atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP) are cardiac hormones synthesized in and secreted from the heart. ANP and BNP bind the common receptor guanylyl cyclase-A (GC-A) and possess biological actions. Based on their diuretic, natriuretic, and vasodilating activities, they are now widely us...

journal_title：Canadian journal of physiology and pharmacology

authors： Saito Y,Kishimoto I,Nakao K

更新日期：2011-08-01 00:00:00

abstract：:The twitch-potentiating effects of opioids in the frog's skeletal muscle which are naloxone resistant and nonstereospecific were further studied. The rapid kinetics of the onset and of the offset (following washout) of the opioid effect indicates that the site for this action is the surface membrane of the muscle fibr...

journal_title：Canadian journal of physiology and pharmacology

authors： Shetty SS,Frank GB

更新日期：1986-07-01 00:00:00

abstract：:In urethane-anaesthetized rats, ion-selective microelectrodes recorded changes in extracellular K+ and Ca2+ concentrations (delta[K+]omicron and delta[Ca2+]omicron) in pyramidal layers of the hippocampus (mostly in area CA1), which were evoked by fimbrial-commissural stimulation. [K+]omicron increased linearly with fr...

journal_title：Canadian journal of physiology and pharmacology

authors： Krnjević K,Morris ME,Reiffenstein RJ

更新日期：1982-12-01 00:00:00

abstract：:The lysosomal protease cathepsin D increased markedly in brown adipocytes during differentiation in primary cultures. Differentiated cells had 20 times the amount of immunoreactive cathepsin D found in preadipocytes. Cathepsin D mRNA, as estimated by relative RT-PCR, was also present in higher amounts in differentiate...

journal_title：Canadian journal of physiology and pharmacology

authors： Moazed B,Desautels M

更新日期：2002-06-01 00:00:00

abstract：:The effect of oleate (0.3 and 1.2 mM) and the combined effect of beta-hydroxybutyrate (4 and 8 mM) and acetoacetate (1 and 2 mM) on rates of lipolysis (glycerol output) was determined with calcium-tolerant myocytes isolated from the hearts of normal rats and hearts from acutely (2-3 days; 100 mg/kg streptozotocin) dia...

journal_title：Canadian journal of physiology and pharmacology

authors： Larsen TS,Severson DL

更新日期：1990-09-01 00:00:00

abstract：:Significant tension development resulting from the administration of lanthanum salts (La3+) to isolated aorta tissues was observed in preparations from the spontaneously hypertensive rat (SHR) but not in preparation from age-matched normotensive Wistar rats (NWR). The response to La3+ was significantly greater in tiss...

journal_title：Canadian journal of physiology and pharmacology

authors： Goldberg MT,Triggle CR

更新日期：1977-10-01 00:00:00

abstract：:Grains are global dietary staples that when consumed in whole grain form, offer considerable health benefits compared with milled grain foods, including reduced body weight gain and reduced cardiovascular and diabetes risks. Dietary patterns, functional foods, and other lifestyle factors play a fundamental role in the...

journal_title：Canadian journal of physiology and pharmacology

authors： Nelson K,Stojanovska L,Vasiljevic T,Mathai M

更新日期：2013-06-01 00:00:00

abstract：:This study investigated the effects of prolonged exercise on muscle sarcoplasmic reticulum (SR) Ca2+ cycling properties and the metabolic responses with and without a session of exercise designed to reduce muscle glycogen reserves while on a normal carbohydrate (CHO) diet. Eight untrained males (VO(2peak) = 3.81 +/- 0...

journal_title：Canadian journal of physiology and pharmacology

authors： Duhamel TA,Green HJ,Perco JG,Ouyang J

更新日期：2005-07-01 00:00:00

abstract：:There is increasing evidence for a beneficial effect of ginseng on cardiac pathology. Here, we determined whether North American ginseng can modulate the deleterious effects of the β-adrenoceptor agonist isoproterenol on cardiac hypertrophy and function using in vitro and in vivo approaches. Isoproterenol was administ...

journal_title：Canadian journal of physiology and pharmacology

authors： Tang X,Gan XT,Rajapurohitam V,Huang CX,Xue J,Lui EM,Karmazyn M

更新日期：2016-12-01 00:00:00

abstract：:Transcranial magnetic stimulation over the motor cortex was used to construct a map of the effective sites on the scalp from which short-latency electromyogram responses could be evoked in muscles proximal to either an amputation stump (two subjects) or an ischemically anesthetized forearm (two subjects). At rest, the...

journal_title：Canadian journal of physiology and pharmacology

authors： Ridding MC,Rothwell JC

更新日期：1995-02-01 00:00:00

abstract：:The mechanism whereby chronic rapid ventricular pacing induces severe heart failure is unclear, but the phenomenon is associated with a reduction in left ventricular ATP levels. Accordingly, the current study was undertaken to evaluate the acute effects of rapid ventricular pacing on hemodynamics, left ventricular ade...

journal_title：Canadian journal of physiology and pharmacology

authors： Simmons WW,Moe GW,Grima EA,Howard RJ,Armstrong PW

更新日期：1994-01-01 00:00:00

abstract：:An investigation was made of the radiosensitivity of the toxic and immunological properties of Androctonus australis hector venom. This venom was irradiated with two doses of gamma rays (1 and 2 kGy) from a 60Co source. The results showed that venom toxicity was abolished for the two radiation doses (1 and 2 kGy) with...

journal_title：Canadian journal of physiology and pharmacology

authors： Abib L,Laraba-Djebari F

更新日期：2003-12-01 00:00:00

abstract：:Our objective was to produce reductions in the luminal volume of Henle's loop and increases in linear flow velocity through the loop. We did this in a recollection micropuncture study by collecting fluid with and without suction from early distal tubules. With suction, transit time of fast green dye through the loop d...

journal_title：Canadian journal of physiology and pharmacology

authors： Baines AD,Wu CK

更新日期：1975-04-01 00:00:00

abstract：:This study has investigated the oral activity, following intragastric administration, of three potent and long-acting peptide-based bradykinin antagonists, HOE-140, B9430, and CP-0597, in the anesthetized rat, using bradykinin-induced hypotension. Two of the three bradykinin antagonists, B9430 and HOE-140, but not CP-...

journal_title：Canadian journal of physiology and pharmacology

authors： Whalley ET,Hanson WL,Stewart JM,Gera L

更新日期：1997-06-01 00:00:00

abstract：:The our objective was to investigate the adaptations induced by a low-protein, high-carbohydrate (LPHC) diet in growing rats, which by comparison with the rats fed a control (C) diet at displayed lower fasting glycemia and similar fasting insulinemia, despite impairment in insulin signaling in adipose tissues. In the ...

journal_title：Canadian journal of physiology and pharmacology

authors： Pereira MP,Buzelle SL,Batistela E,Doneda DL,França SA,Santos MP,Andrade CM,Garófalo MA,Kettelhut Ido C,Navegantes LC,Chaves VE,Bertolini GL,Kawashita NH

更新日期：2014-06-01 00:00:00