Rationale for using pathologic tumor dimensions and nodal status to subclassify surgically treated stage IB cervical cancer patients.

abstract：BACKGROUND:Glucocorticoid receptor (GR) has emerged as an important steroid nuclear receptor in hormone dependent cancers, however few data are available regarding a potential role of GR in endometrial cancer. The aim of this study was to investigate expression of GR in primary and metastatic endometrial cancer lesions...

journal_title：Gynecologic oncology

authors： Tangen IL,Veneris JT,Halle MK,Werner HM,Trovik J,Akslen LA,Salvesen HB,Conzen SD,Fleming GF,Krakstad C

更新日期：2017-12-01 00:00:00

abstract：OBJECTIVES:Radiation treatment is one of the most standardized and effective modalities for contemporary cervical cancer therapy. In addition, the radiation-potentiating effects of retinoic acid have been recently described. In order to investigate whether enhanced immunogenicity might be responsible for such potentiat...

journal_title：Gynecologic oncology

authors： Santin AD,Hermonat PL,Ravaggi A,Chiriva-Internati M,Hiserodt JC,Pecorelli S,Parham GP

更新日期：1998-08-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to compare the histopathologic features and prognosis of patients with endometrial carcinoma with and without concomitant hyperplasia. METHODS:Histologic slides of the surgical specimens of 214 consecutive patients who underwent surgery as primary treatment for endometrial carcinom...

journal_title：Gynecologic oncology

authors： Gücer F,Reich O,Tamussino K,Bader AA,Pieber D,Schöll W,Haas J,Petru E

更新日期：1998-04-01 00:00:00

abstract：OBJECTIVE:To estimate the likelihood of occult cancer diagnosis at prophylactic oophorectomy in BRCA1 and BRCA2 carriers in different age groups and to determine the histopathology of these lesions. METHODS:We describe a series of 159 female BRCA1 or BRCA2 carriers who underwent prophylactic oophorectomy at the Univer...

journal_title：Gynecologic oncology

authors： Finch A,Shaw P,Rosen B,Murphy J,Narod SA,Colgan TJ

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Metformin has been associated with reduced cancer risk. The mechanisms underlying this cancer protective effect remain unknown. METHODS:"Window of opportunity" study of metformin in women with operable endometrial cancer (EC). Eleven newly diagnosed, untreated, non-diabetic patients with EC received metform...

journal_title：Gynecologic oncology

authors： Laskov I,Drudi L,Beauchamp MC,Yasmeen A,Ferenczy A,Pollak M,Gotlieb WH

更新日期：2014-09-01 00:00:00

abstract：OBJECTIVE:The objective of this study was to determine the incidence of thrombocytosis in epithelial ovarian carcinoma and examine associations with clinico-pathologic features. Thrombocytosis (platelet counts >400 x 10(9)/l) has been identified as a poor prognostic factor in many cancers. Platelet-secreted factors may...

journal_title：Gynecologic oncology

authors： Li AJ,Madden AC,Cass I,Leuchter RS,Lagasse LD,Karlan BY

更新日期：2004-01-01 00:00:00

abstract：:Sixty-eight patients with FIGO stage I, grade 2 or 3 adenocarcinoma of the endometrium were treated according to a protocol involving 10 Gy external pelvic irradiation, prompt hysterectomy with surgical staging, and postoperative therapy individualized according to surgical-pathologic findings. Five-year survival for ...

journal_title：Gynecologic oncology

authors： Shimm DS,Wang CC,Fuller AF Jr,Nelson JH Jr,Nikrui N,Young RH,Scully RE

更新日期：1986-02-01 00:00:00

abstract：:An estimated 2-5% of endometrial cancers and 15-20% of high-grade, non-mucinous epithelial ovarian cancers have an underlying hereditary cause. Appropriate risk assessment, genetic counseling, and germline genetic testing for cancer predisposition genes in both gynecologic cancer patients and their at-risk relatives i...

journal_title：Gynecologic oncology

authors： Hinchcliff EM,Bednar EM,Lu KH,Rauh-Hain JA

更新日期：2019-04-01 00:00:00

abstract：OBJECTIVE:To determine whether written information and/or counseling based on the WOMAN-PRO II Program decreases symptom prevalence in women with vulvar neoplasia by a clinically relevant degree, and to explore the differences between the 2 interventions in symptom prevalence, symptom distress prevalence, and symptom e...

journal_title：Gynecologic oncology

authors： Raphaelis S,Mayer H,Ott S,Mueller MD,Steiner E,Joura E,Senn B

更新日期：2017-07-01 00:00:00

abstract：:A 65-year-old woman had a total abdominal hysterectomy and bilateral salpingo-oophorectomy through a Pfannenstiel incision for a Stage Ib, Grade 2 endometrial adenocarcinoma with extension to the middle third of the myometrium. No adjuvant treatment was given. She presented 7 years later with a large suprapubic mass a...

journal_title：Gynecologic oncology

authors： Kotwall CA,Kirkbride P,Zerafa AE,Murray D

更新日期：1994-06-01 00:00:00

abstract：BACKGROUND:It has been suggested that mutation of the TP53 tumor suppressor gene is involved in endometrial carcinogenesis. However, the status of p53 function in endometrial cancers has not yet been investigated in detail. METHODS:We surveyed inactivating p53 mutations in endometrial carcinomas using the yeast p53 fu...

journal_title：Gynecologic oncology

authors： Sakuragi N,Hirai A,Tada M,Yamada H,Yamamoto R,Fujimoto S,Moriuchi T

更新日期：2001-12-01 00:00:00

abstract：OBJECTIVES:The objective of this pilot study was to determine if frailty predicts surgical complications among elderly women undergoing gynecologic oncology procedures. METHODS:A cohort of gynecologic oncology patients age ≥ 65, undergoing surgery between March and December 2011 was identified. Frailty was evaluated u...

journal_title：Gynecologic oncology

authors： Courtney-Brooks M,Tellawi AR,Scalici J,Duska LR,Jazaeri AA,Modesitt SC,Cantrell LA

更新日期：2012-07-01 00:00:00

abstract：OBJECTIVE:The aim of the study was to examine whether comorbidity is an independent prognostic factor for 3129 women diagnosed with ovarian cancer from 2005 to 2011. As Performance status (PS) might capture the impact of comorbidity we addressed whether comorbidity can be explained by PS or whether comorbidity has an i...

journal_title：Gynecologic oncology

authors： Sperling C,Noer MC,Christensen IJ,Nielsen ML,Lidegaard Ø,Høgdall C

更新日期：2013-04-01 00:00:00

abstract：:In the field of gynecologic oncology, surgical intervention has been the traditional management of postoperative abdominal hemorrhage. Recently, arterial embolization has been reported to effectively control vaginal hemorrhage associated with gynecologic malignancy, obstetrical trauma, and hysterectomy. This study rep...

journal_title：Gynecologic oncology

authors： O'Hanlan KA,Trambert J,Rodriguez-Rodriguez L,Goldberg GL,Runowicz CD

更新日期：1989-08-01 00:00:00

abstract：:The interaction of human gestational choriocarcinoma cell line, SMT-cc1, with bovine vascular endothelial cells, CPAE, was examined in an in vitro coculture model. SMT-cc1 cells have urokinase-type plasminogen activator (uPA) on their cell surface, and more than half of the cell-associated uPA is enzymatically inactiv...

journal_title：Gynecologic oncology

authors： Sugimura M,Kobayashi H,Terao T

更新日期：1994-03-01 00:00:00

abstract：OBJECTIVE:To evaluate the survival impact of residual disease at the time of primary surgery for patients with Stage III and IV endometrial carcinoma; to assess morbidity associated with surgical cytoreduction. METHOD:All patients with endometrial carcinoma who underwent primary surgical therapy at the University of M...

journal_title：Gynecologic oncology

authors： Lambrou NC,Gómez-Marín O,Mirhashemi R,Beach H,Salom E,Almeida-Parra Z,Peñalver M

更新日期：2004-06-01 00:00:00

abstract：BACKGROUND:Luteinized thecoma of the ovary associated with sclerosing peritonitis is a rare tumor that has no standard definitive treatment regimen. CASE:A 25 year-old patient diagnosed with luteinized thecoma and sclerosing peritonitis in the omentum. The patient received high dose corticosteroids (IV Hydrocortisone ...

journal_title：Gynecologic oncology

authors： Schonman R,Klein Z,Edelstein E,Czernobilsky B,Fishman A

更新日期：2008-12-01 00:00:00

abstract：OBJECTIVE:Molecular chaperone 78 kDa glucose-regulated protein (GRP78) is a residential protein in the endoplasmic reticulum (ER) that is induced by an unfolded-protein response triggered under many kinds of stress against a cell. GRP78 is also known to act as an anti-apoptotic factor by protecting ER-stress-induced ce...

journal_title：Gynecologic oncology

authors： Luvsandagva B,Nakamura K,Kitahara Y,Aoki H,Murata T,Ikeda S,Minegishi T

更新日期：2012-07-01 00:00:00

abstract：:Primary lymphoma of the cervix is very rare. A case report is presented and 24 cases published in the English literature are reviewed. Evaluation, staging, treatment, and prognosis of this rare tumor are discussed. ...

journal_title：Gynecologic oncology

authors： Mann R,Roberts WS,Gunasakeran S,Tralins A

更新日期：1987-01-01 00:00:00

abstract：OBJECTIVE:Our objective was to determine the rate of BRCA1/2 deficiency in platinum-sensitive and platinum-resistant tumors from a cohort of unselect patients with advanced epithelial ovarian cancer (EOH). METHODS:BRCA1/2 mutation analysis was performed in 29 patients with platinum-sensitive EOC and 24 patients with p...

journal_title：Gynecologic oncology

authors： Dann RB,DeLoia JA,Timms KM,Zorn KK,Potter J,Flake DD 2nd,Lanchbury JS,Krivak TC

更新日期：2012-06-01 00:00:00

abstract：OBJECTIVE:To evaluate testing for high-risk human papillomavirus (HR HPV) E6/E7 mRNA transcripts 6 months after conisation for cervical intraepithelial neoplasia grade 2 or worse (CIN2+) to determine the risk of residual CIN2+. METHODS:We prospectively followed 344 women treated for CIN2+ by conisation. HR HPV mRNA te...

journal_title：Gynecologic oncology

authors： Tropé A,Jonassen CM,Sjøborg KD,Nygård M,Dahl FA,Alfsen GC,Lie AK

更新日期：2011-11-01 00:00:00

abstract：OBJECTIVE:Implicit prejudice and stereotyping may exist in health care providers automatically without their awareness. These biases can correlate with outcomes that are consequential for the patient. This study examined gynecologic oncology care providers' implicit prejudice and stereotyping toward cervical cancer. M...

journal_title：Gynecologic oncology

authors： Liang J,Wolsiefer K,Zestcott CA,Chase D,Stone J

更新日期：2019-04-01 00:00:00

abstract：OBJECTIVE:Previous studies suggest that differences in molecular features of endometrial cancers between racial groups may contribute to the poorer survival in Blacks. The objective of this investigation was to determine whether gene expression among endometrial cancers is different between Blacks and Whites. METHODS:...

journal_title：Gynecologic oncology

authors： Maxwell GL,Allard J,Gadisetti CV,Litzi T,Casablanca Y,Chandran U,Darcy KM,Levine DA,Berchuck A,Hamilton CA,Conrads TP,Risinger JI

更新日期：2013-07-01 00:00:00

abstract：OBJECTIVE:To update the demographic data, treatment details and outcomes for GTN patients with brain metastases managed with the modern treatment protocols at the UK centre for gestational trophoblast neoplasia at Charing Cross Hospital in London. METHODS:The hospital database and pharmacy records were reviewed to ide...

journal_title：Gynecologic oncology

authors： Savage P,Kelpanides I,Tuthill M,Short D,Seckl MJ

更新日期：2015-04-01 00:00:00

abstract：OBJECTIVE:To investigate racial disparities with respect to adjuvant treatment and survival in patients presenting with malignant ovarian germ cell tumors (OGCT). METHODS:The National Cancer Database (NCDB) was used to identify women diagnosed with OGCT. Demographic data were abstracted, including stratification by ra...

journal_title：Gynecologic oncology

authors： Hinchcliff E,Rauh-Hain JA,Clemmer JT,Diver E,Hall T,Stall J,Growdon W,Clark R,Schorge J

更新日期：2016-03-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to confirm a causal relationship between removal of circumflex iliac nodes to the distal external iliac nodes (CINDEIN) and lower-extremity lymphedema after systematic lymphadenectomy in patients with uterine corpus malignancies. METHODS:A retrospective chart review was carried out ...

journal_title：Gynecologic oncology

authors： Todo Y,Yamazaki H,Takeshita S,Ohba Y,Sudo S,Minobe S,Okamoto K,Kato H

更新日期：2015-10-01 00:00:00

abstract：OBJECTIVE:Since 1999, patients with low risk endometrial cancer (EC) as defined by the Mayo criteria have preferably not undergone lymphadenectomy (LND) at our institution. Here we prospectively assess survival, sites of recurrence, morbidity, and cost in this low risk cohort. METHODS:Cause-specific survival (CSS) was...

journal_title：Gynecologic oncology

authors： Dowdy SC,Borah BJ,Bakkum-Gamez JN,Weaver AL,McGree ME,Haas LR,Keeney GL,Mariani A,Podratz KC

更新日期：2012-10-01 00:00:00

abstract：OBJECTIVE:To profile long non-coding RNA (lncRNA) expression at the various anatomic sites of high-grades serous carcinoma (HGSC) and in effusion-derived exosomes. METHODS:LncRNA profiling was performed on 60 HGSC specimens, including 10 ovarian tumors, 10 solid metastases and 10 malignant effusions, as well as exosom...

journal_title：Gynecologic oncology

authors： Filippov-Levy N,Cohen-Schussheim H,Tropé CG,Hetland Falkenthal TE,Smith Y,Davidson B,Reich R

更新日期：2018-03-01 00:00:00

abstract：OBJECTIVE:The first-line chemotherapy for ovarian cancer is based on a combination of platinum and taxane. To date, no reliable predictive biomarker has been recognized that is capable of identifying patients with pre-existing resistance to these agents. Here, we have established an integrated database and identified t...

journal_title：Gynecologic oncology

authors： Fekete JT,Ősz Á,Pete I,Nagy GR,Vereczkey I,Győrffy B

更新日期：2020-03-01 00:00:00

abstract：OBJECTIVE:ATP-binding Cassette (ABC) transporters are thought to cause multiple drug resistance (MDR) in various carcinomas. Gene expression data from individual transporters in ovarian cancer tissue is contradictory and also scarce for some of them. RNA levels of a panel of ABC transporters were collected and analyzed...

journal_title：Gynecologic oncology

authors： Auner V,Sehouli J,Oskay-Oezcelik G,Horvat R,Speiser P,Zeillinger R

更新日期：2010-05-01 00:00:00