Concomitant endometrial hyperplasia in patients with endometrial carcinoma.

Abstract:

OBJECTIVES:The aim of this study was to compare the histopathologic features and prognosis of patients with endometrial carcinoma with and without concomitant hyperplasia. METHODS:Histologic slides of the surgical specimens of 214 consecutive patients who underwent surgery as primary treatment for endometrial carcinoma from 1985 through 1991 were reviewed. RESULTS:Ninety-two of the 214 patients (43%) with endometrial carcinoma had concomitant endometrial hyperplasia. Patients with endometrial carcinoma with hyperplasia were significantly younger than those without hyperplasia (mean age 62 +/- 10 vs 65 +/- 9 years, P < 0.05). Carcinomas associated with hyperplasia were better differentiated and of lower surgical stage. By univariate analysis the frequency of recurrence was significantly lower (4% vs 17%, P < 0.004) and the estimated 5-year survival rate significantly higher (96% vs 85%, P < 0.01) in patients with endometrial carcinoma with concomitant hyperplasia. However, in multivariate analysis the presence of endometrial hyperplasia was not an independent prognostic factor and the 5-year survival rates of patients with or without hyperplasia did not differ significantly in any surgical stage. CONCLUSION:The presence or absence of concomitant endometrial hyperplasia is strongly correlated with the surgical stage of endometrial carcinoma.

journal_name

Gynecol Oncol

journal_title

Gynecologic oncology

authors

Gücer F,Reich O,Tamussino K,Bader AA,Pieber D,Schöll W,Haas J,Petru E

doi

10.1006/gyno.1997.4911

subject

Has Abstract

pub_date

1998-04-01 00:00:00

pages

64-8

issue

1

eissn

0090-8258

issn

1095-6859

pii

S0090-8258(97)94911-8

journal_volume

69

pub_type

杂志文章
  • Metastatic serous borderline ovarian tumor in an internal mammary lymph node: a case report and review of the literature.

    abstract::Background. Reports of supradiaphragmatic involvement of lymph nodes by serous borderline ovarian tumors are rare. Case. We describe the finding of metastatic tumor involving an internal mammary lymph node in a 74-year-old patient with serous borderline ovarian tumor. The positive lymph node was found incidentally dur...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,评审

    doi:10.1006/gyno.2001.6234

    authors: Chamberlin MD,Eltabbakh GH,Mount SL,Leavitt BJ

    更新日期:2001-07-01 00:00:00

  • Fatal radiation hepatitis: a case report and review of the literature.

    abstract::A case of fatal radiation hepatitis occurring after treatment with 2200 rad given by the moving strip technique is presented. This fatality occurred in a 28-year-old woman with persistent ovarian carcinoma despite prolonged chemotherapy. Scans of the liver using computerized tomography, 99mTc sulfur colloid, and 99mTc...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/0090-8258(86)90316-1

    authors: Schacter L,Crum E,Spitzer T,Maksem J,Diwan V,Kolli S

    更新日期:1986-07-01 00:00:00

  • Long term follow-up of a large series of stage-II/III atypical proliferative serous ovarian tumors.

    abstract:BACKGROUND:The aim of this study was to assess prognostic factors and implications on further management in a large series of stage-II or III Atypical Proliferative Serous Tumors (APST) with a long-term follow-up. PATIENTS AND METHODS:Patients with APSTs and peritoneal implants treated in, or referred to, our institut...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/j.ygyno.2020.06.489

    authors: Maria S,Faron M,Maulard A,Pautier P,Leary A,Chargari C,Genestie C,Gouy S,Morice P

    更新日期:2020-09-01 00:00:00

  • Assessment of inhibin and p53 in granulosa cell tumors of the ovary.

    abstract:OBJECTIVE:The goal of this work was to determine the cellular content of inhibin and p53 in granulosa cell tumors (GCTs). METHODS:Clinical records of 47 patients (mean age, 54 years; range, 20-85 years) presenting with GCT surgically managed at our institution were abstracted. International Federation of Gynecology st...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1006/gyno.2000.5774

    authors: Gebhart JB,Roche PC,Keeney GL,Lesnick TG,Podratz KC

    更新日期:2000-05-01 00:00:00

  • The role of vaginal cuff brachytherapy in endometrial cancer.

    abstract:OBJECTIVE:The purpose of this article is to review the data, rationale, and recommendations of vaginal brachytherapy (VBT) in the post-operative treatment of endometrial cancer patients. METHODS:The authors performed a thorough review of the medical literature regarding the use of adjuvant VBT in the treatment of endo...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,评审

    doi:10.1016/j.ygyno.2014.12.036

    authors: Harkenrider MM,Block AM,Siddiqui ZA,Small W Jr

    更新日期:2015-02-01 00:00:00

  • An immunohistochemical study of colon-ovarian tumor antigen and colon-specific antigen in gynecologic tumors.

    abstract::The distribution of colon--ovarian tumor antigen (COTA) and colon-specific antigen (CSA) was studied immunohistochemically in gynecologic tumors. The antigens were absent in the serous benign tumors of the ovary and in the normal ovarian tissues, whereas they were detected in some of the mucinous benign tumors. COTA a...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/0090-8258(89)90019-x

    authors: Ueda G,Shimizu C,Saito J,Tanaka Y,Inoue M,Tanizawa O

    更新日期:1989-10-01 00:00:00

  • A case of invasive squamous cell carcinoma on the surface of pedunculated cervical leiomyoma presenting an exophytic cervical cancer.

    abstract:BACKGROUND:Cervical cancer on the mucosal surface of a pedunculated cervical leiomyoma has not been reported. CASE:A 54-year-old woman who had a bulky protruding cervical tumor with a history of a vaginal bleeding was diagnosed as having squamous cell cancer of the cervix. She received a total of 45 Gy (1.8 Gy daily u...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/j.ygyno.2004.12.021

    authors: Rim Nam H,Jae Huh S,Taik Park C,Kim B,Ahn G

    更新日期:2005-04-01 00:00:00

  • The performance of Dynamic Spectral Imaging colposcopy depends on indication for referrals.

    abstract::OBJECTIVE. A previous study has shown that Dynamic Spectral Imaging (DSI) colposcopy increases the sensitivity of the colposcopic examination in women referred with abnormal cytology. In this study we have reanalyzed the performance of DSI and conventional colposcopy for new referral conditions and for low-grade cytol...

    journal_title:Gynecologic oncology

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1016/j.ygyno.2015.10.009

    authors: Louwers JA,Zaal A,Kocken M,Berkhof J,Papagiannakis E,Snijders PJ,Meijer CJ,Verheijen RH

    更新日期:2015-12-01 00:00:00

  • Primary non-gestational choriocarcinoma of the uterine cervix: a case report.

    abstract:BACKGROUND:Primary non-gestational choriocarcinoma of the female genital tract has been described in the ovaries and is very unusual in other genital sites. CASE:Primary non-gestational uterine cervical choriocarcinoma was diagnosed in a patient, 32, single, without previous sexual contact nor antecedent pregnancy, ad...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/j.ygyno.2005.03.045

    authors: Maestá I,Michelin OC,Traiman P,Hokama P,Rudge MV

    更新日期:2005-07-01 00:00:00

  • A phase II trial of bisantrene (CL216,942) in refractory epithelial ovarian cancer.

    abstract::Twenty-three evaluable patients with refractory epithelial ovarian cancer were treated with bisantrene (CL216,942). The drug was given as a single-dose injection every 3 weeks. One patient (4%) showed a partial response. The compound thus has limited activity against this malignancy. ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/0090-8258(86)90113-7

    authors: Kavanagh JJ,Gershenson DM,Saul PB,Copeland LJ

    更新日期:1986-01-01 00:00:00

  • Cervical dysplasia in women infected with the human immunodeficiency virus (HIV): a correlation with HIV viral load and CD4+ count.

    abstract:OBJECTIVES:The incidence of cervical dysplasia and carcinoma is known to be increased in HIV-infected women. In addition, there is a positive correlation between HIV viral load (VL), CD4+ count, and opportunistic infections, as well as the incidence of various malignancies. This study compares HIV VL and CD4+ count wit...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1006/gyno.2000.6104

    authors: Davis AT,Chakraborty H,Flowers L,Mosunjac MB

    更新日期:2001-03-01 00:00:00

  • Synovial cell sarcoma of the vulva: multimodality treatment incorporating preoperative external-beam radiation, hemivulvectomy, flap reconstruction, interstitial brachytherapy, and chemotherapy.

    abstract:BACKGROUND:Vulvar synovial cell sarcomas are rare, with only four previously published cases in the literature. Traditionally, the primary management for these tumors has been surgery alone. CASE:We report a case of a large vulvar synovial cell sarcoma in a 50-year-old woman treated with comprehensive combined multimo...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/j.ygyno.2006.09.018

    authors: Holloway CL,Russell AH,Muto M,Albert M,Viswanathan AN

    更新日期:2007-01-01 00:00:00

  • Surgical approach to diaphragmatic metastases from ovarian cancer.

    abstract::Fourteen patients underwent surgical debulking of diaphragmatic metastases as part of cytoreductive surgery for advanced ovarian epithelial cancer from 1983 to 1984. The surgical technique is described. Morbidity from this approach was not excessive in this small series of patients. It is suggested that this technique...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/0090-8258(86)90034-x

    authors: Deppe G,Malviya VK,Boike G,Hampton A

    更新日期:1986-06-01 00:00:00

  • Prognostic factors for groin node metastasis in squamous cell carcinoma of the vulva (a Gynecologic Oncology Group study)

    abstract::From 1977 to 1984 the Gynecologic Oncology Group (GOG) conducted a prospective clinical and surgical staging protocol of squamous cell carcinoma of the vulva (n = 637). The patients with superficial (5 mm or less invasion) lesions were the subject of a previous report (n = 272). The subject of this report is on factor...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1006/gyno.1993.1127

    authors: Homesley HD,Bundy BN,Sedlis A,Yordan E,Berek JS,Jahshan A,Mortel R

    更新日期:1993-06-01 00:00:00

  • Endometrial pathologies associated with postmenopausal tamoxifen treatment.

    abstract:OBJECTIVE:To evaluate various endometrial pathologies described in association with postmenopausal tamoxifen treatment, as well as the clinical aspects of these endometrial pathologies. METHODS:A search was made in PUB MED for all studies published in English, up to the end of 2003, reporting on endometrial pathologie...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,评审

    doi:10.1016/j.ygyno.2004.03.048

    authors: Cohen I

    更新日期:2004-08-01 00:00:00

  • Vaginal reconstruction at the time of pelvic exenteration: a surgical and psychosexual analysis of techniques.

    abstract:OBJECTIVES:Vaginal reconstruction following pelvic exenteration is an important aspect of the physical and psychological rehabilitation of women after radical surgery for pelvic malignancies. The choice of techniques is vast, and proper patient and surgical selection is important for obtaining satisfactory functional a...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1006/gyno.2002.6780

    authors: Mirhashemi R,Averette HE,Lambrou N,Penalver MA,Mendez L,Ghurani G,Salom E

    更新日期:2002-10-01 00:00:00

  • Pathways to a cancer-free future: A protocol for modelled evaluations to maximize the future impact of interventions on cervical cancer in Australia.

    abstract:OBJECTIVE:Australia's HPV vaccination and HPV-based cervical screening programs are changing the landscape in cervical cancer prevention. We aim to identify areas which can make the biggest further impact on cervical cancer burden. This protocol describes the first stage of a program of work called Pathways-Cervix that...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/j.ygyno.2018.12.019

    authors: Velentzis LS,Smith MA,Simms KT,Lew JB,Hall M,Hughes S,Yuill S,Killen J,Keane A,Butler K,Darlington-Brown J,Hui H,Brotherton JML,Skinner R,Brand A,Roeske L,Heley S,Carter J,Bateson D,Frazer I,Garland SM,Guy R,H

    更新日期:2019-03-01 00:00:00

  • Palliative radiotherapy for recurrent granulosa cell tumor of the ovary: a report of 3 cases with radiological evidence of response.

    abstract:BACKGROUND:The role of radiotherapy for recurrent or residual granulosa cell tumor of the ovary (GCTO) is controversial. One reason for this controversy may be that most published studies on this topic have not utilized sectional imaging to assess response to radiotherapy. We report on three cases of recurrent or resid...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/j.ygyno.2006.02.034

    authors: E C,Samant R,Fung MF,Le T,Hopkins L,Senterman M

    更新日期:2006-08-01 00:00:00

  • Cost-effectiveness of adding bevacizumab to first line therapy for patients with advanced ovarian cancer.

    abstract:OBJECTIVE:To evaluate, from a societal perspective, the cost-effectiveness of adding bevacizumab to first-line therapy based on outcomes from the GOG-218 and ICON-7 trials. METHODS:A three-state Markov model was used. The time horizon was until the death of 99% of the initial cohort of 1000 individuals. Costs and qual...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/j.ygyno.2014.01.021

    authors: Mehta DA,Hay JW

    更新日期:2014-03-01 00:00:00

  • Neoadjuvant intraarterial chemotherapy followed by radical hysterectomy and/or radiotherapy for locally advanced cervical cancer.

    abstract:OBJECTIVES:We assessed neoadjuvant intraarterial chemotherapy (NAC) followed by radical hysterectomy and/or radiotherapy in patients with locally advanced cervical cancer. METHODS:Over 5 years, 48 consecutive women with International Federation of Gynecology and Obstetrics stage IIb-IVa cervical cancer were enrolled. ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1006/gyno.1998.4976

    authors: Sugiyama T,Nishida T,Hasuo Y,Fujiyoshi K,Yakushiji M

    更新日期:1998-05-01 00:00:00

  • A randomized study of the effectiveness of a brief psychosocial intervention for women attending a gynecologic cancer clinic.

    abstract:OBJECTIVES:While there are many psychosocial interventions for cancer patients, few are brief in nature. The aim of this study was to investigate the usefulness of a single-visit psychosocial intervention for gynecologic cancer patients. METHODS:One hundred women attending a gynecologic cancer clinic as new patients w...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.ygyno.2008.06.024

    authors: Powell CB,Kneier A,Chen LM,Rubin M,Kronewetter C,Levine E

    更新日期:2008-10-01 00:00:00

  • Real-time near-infrared fluorescence guided surgery in gynecologic oncology: a review of the current state of the art.

    abstract::Near-infrared (NIR) fluorescence imaging has emerged as a promising complimentary technique for intraoperative visualization of tumor tissue, lymph nodes and vital structures. In this review, the current applications and future opportunities of NIR fluorescence imaging in gynecologic oncology are summarized. Several s...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,评审

    doi:10.1016/j.ygyno.2014.08.005

    authors: Handgraaf HJ,Verbeek FP,Tummers QR,Boogerd LS,van de Velde CJ,Vahrmeijer AL,Gaarenstroom KN

    更新日期:2014-12-01 00:00:00

  • A phase II trial of cisplatin, ifosfamide, and mesna in patients with advanced or recurrent uterine malignant mixed müllerian tumors with evaluation of potential molecular targets.

    abstract:OBJECTIVE:The aim of this study was to determine the efficacy of cisplatin, ifosfamide, and mesna in uterine malignant mixed müllerian tumor (MMMT) and to evaluate the expression of clinically relevant molecular markers. METHODS:Women with advanced or recurrent MMMT were treated every 28 days with cisplatin (75 mg/m(2...

    journal_title:Gynecologic oncology

    pub_type: 临床试验,杂志文章

    doi:10.1016/s0090-8258(03)00332-9

    authors: Ramondetta LM,Burke TW,Jhingran A,Schmandt R,Bevers MW,Wolf JK,Levenback CF,Broaddus R

    更新日期:2003-09-01 00:00:00

  • Evaluating class III antiarrhythmic agents as novel MYC targeting drugs in ovarian cancer.

    abstract:OBJECTIVE:To evaluate the utility of amiodarone and its derivative dronedarone as novel drug repositioning candidates in EOC and to determine the potential pathways targeted by these drugs. METHODS:Drug-predict bioinformatics platform was used to assess the utility of amiodarone as a novel drug-repurposing candidate i...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/j.ygyno.2018.09.019

    authors: Belur Nagaraj A,Joseph P,Kovalenko O,Wang Q,Xu R,DiFeo A

    更新日期:2018-12-01 00:00:00

  • Chemoradiation in locally advanced cervical carcinoma: an analysis of cisplatin dosing and other clinical prognostic factors.

    abstract:OBJECTIVES:The aim of this study was to evaluate the effect of number of chemotherapy cycles and other clinical and pathologic factors on progression-free (PFS) and overall survival (OS) in patients with newly diagnosed cervical cancer. METHODS:We identified 118 patients with locally advanced cervical cancer (stages I...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/j.ygyno.2009.09.045

    authors: Nugent EK,Case AS,Hoff JT,Zighelboim I,DeWitt LL,Trinkhaus K,Mutch DG,Thaker PH,Massad LS,Rader JS

    更新日期:2010-03-01 00:00:00

  • Predictive value of HPV DNA in lymph nodes in surgically treated cervical carcinoma patients--a prospective study.

    abstract:OBJECTIVE:High-risk types of HPV are etiological factors in cervical cancer. Lymph node involvement in cervical cancer patients reduces 5-year survival rates by 25-60%. However, the influence on survival of HPV DNA positivity in histopathologically negative lymph nodes remains unresolved. METHODS:The study included 11...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/j.ygyno.2006.10.018

    authors: Lukaszuk K,Liss J,Gulczynski J,Nowaczyk M,Nakonieczny M,Piatkowski M,Sliwinski W,Baay M,Wozniak I,Maj B,Lukaszuk M

    更新日期:2007-03-01 00:00:00

  • Absence of PTEN repeat tract mutation in endometrial cancers with microsatellite instability.

    abstract:OBJECTIVE:PTEN, a tumor suppressor gene shown to be frequently mutated in endometrial cancers, has been suggested to be a target of microsatellite instability (MSI)-driven mutagenesis. We set out to investigate the relationship between MSI and PTEN mutation in a large series of primary endometrial carcinomas. METHODS:...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1006/gyno.2000.5900

    authors: Cohn DE,Basil JB,Venegoni AR,Mutch DG,Rader JS,Herzog TJ,Gersell DJ,Goodfellow PJ

    更新日期:2000-10-01 00:00:00

  • Metabolic risk factors and mechanisms of disease in epithelial ovarian cancer: A review.

    abstract:OBJECTIVE:Epithelial ovarian cancer continues to be the deadliest gynecologic malignancy. Patients with both diabetes mellitus and obesity have poorer outcomes, yet research correlating metabolic abnormalities, such as metabolic syndrome, to ovarian cancer risk and outcomes is lacking. This article reviews the literatu...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,评审

    doi:10.1016/j.ygyno.2016.10.005

    authors: Craig ER,Londoño AI,Norian LA,Arend RC

    更新日期:2016-12-01 00:00:00

  • Assessment of DNA Ploidy in the ProMisE molecular subgroups of endometrial cancer.

    abstract:OBJECTIVE:We sought to determine whether DNA ploidy correlates with the four molecular subgroups of endometrial carcinoma (EC) as determined using ProMisE (Proactive Molecular Risk Classifier for Endometrial Cancer). METHODS:90 cases of EC previously characterized by clinicopathological parameters, outcomes, and ProMi...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1016/j.ygyno.2017.06.020

    authors: Proctor L,Pradhan M,Leung S,Cheng A,Lee CH,Soslow RA,Gilks CB,Talhouk A,McAlpine JM,Danielsen HE,Hoang LN

    更新日期:2017-09-01 00:00:00

  • Should the presence of lymphvascular space involvement be used to assign patients to adjuvant therapy following hysterectomy for unstaged endometrial cancer?

    abstract::Objective. Thegoal of this study was to determine the influence of LVSI (lymphvascular space involvement) on the risk of lymph node metastases from endometrial cancer.Methods. All patients with surgically staged endometrial cancer from 1998 to 2000 were identified from divisional databases. The influence of LVSI on th...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章

    doi:10.1006/gyno.2002.6825

    authors: Cohn DE,Horowitz NS,Mutch DG,Kim SM,Manolitsas T,Fowler JM

    更新日期:2002-12-01 00:00:00