[Clinical pharmacological aspects of the proton pump inhibitor therapy: importance of pharmacogenetic differences in the clinical practice].

Abstract:

:Proton pump inhibitors (PPIs) are widely used for the treatment of gastroesophageal reflux disease, as well as other acid-related disorders. Omeprazole, lansoprazole, pantoprazole, rabeprazole and esomeprazole effectively suppress gastric acid secretion by blocking the gastric acid pump, H+/K+ -adenosine triphosphatase (ATPase). Understanding the pharmacokinetic properties of PPIs and examining the pharmacogenetic differences may help clinicians to optimize PPI therapy and to perform individual treatment, especially in non-responder patients with GERD or ulcer or after failed eradication therapy.

journal_name

Orv Hetil

journal_title

Orvosi hetilap

authors

Mullner K,Molnar B,Tulassay Z

doi

10.1556/OH.2007.27902

subject

Has Abstract

pub_date

2007-03-25 00:00:00

pages

543-51

issue

12

eissn

0030-6002

issn

1788-6120

journal_volume

148

pub_type

杂志文章,评审
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  • [The cumulative risk index in stroke prevention].

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  • [Suicidal behavior in the elderly. Review of results at the Pécs Center of the WHO/EURO Multicenter Study on Suicide].

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  • [Polymyositis-dermatomyositis recognized during the follow-up of a patient with type 2 diabetes].

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  • [New anticoagulants in the prevention and treatment of venous thromboembolism].

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  • [Fetal damage caused by contraceptive tablets].

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  • [Thalidomide (Contergan) induced limb deficiency in Hungary?].

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  • [New lasers in dermatologic surgery].

    abstract::Developments in the fields of laser technology and application have significantly broadened its clinical use over the past two decades. As lasers became more smaller, more reliable and less expensive, dermatology will benefit new laser-based therapeutic and diagnostic methods. Relevant laser systems and their clinical...

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