Abstract：
:Clinical data on the risk factors, incidence, consequences and current treatment options of venous thromboembolism are reviewed. Current guidelines advise anticoagulant treatment for a few weeks or months in immobilized patients treated in hospital, and after major surgery. The initial treatment is based on heparin, followed by vitamin K antagonist treatment. Recently a number of new, partially orally administered medications have undergone clinical investigations and based on the results three of them were also registered for the prevention and treatment of venous thromboembolism. Direct thrombin inhibitors, direct and indirect Factor Xa inhibitors exhibited proven non-inferiority or superiority compared with traditional treatment options. The superior efficacy or non-inferiority was not accompanied with an increase in the bleeding risk. Results of the most important clinical trials are reviewed. Based on these results, prevention and treatment of venous thromboembolism will change substantially in the near future.
journal_name
Orv Hetiljournal_title
Orvosi hetilapauthors
Keltai M,Keltai Kdoi
10.1556/OH.2011.29140subject
Has Abstractpub_date
2011-06-19 00:00:00pages
983-92issue
25eissn
0030-6002issn
1788-6120pii
906P701880PW4M5Kjournal_volume
152pub_type
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