当前位置： SCI文献检索 > BRITISH JOURNAL OF PHARMACOLOGY期刊下所有文献 > Converting enzyme inhibition in the rat by captopril is accompanied by potentiation of carrageenin-induced inflammation.

Converting enzyme inhibition in the rat by captopril is accompanied by potentiation of carrageenin-induced inflammation.

Abstract：

:Hind paw oedema in rats, measured by plethysmography or extravasation of Evans Blue dye into the skin, after subplantar injection of submaximal doses of carrageenin (1-100 micrograms) was significantly increased for 4 h during kininase II inhibition with captopril (1 mg kg-1, s.c.). Submaximal oedema, as assessed by paw swelling, after subplantar bradykinin (0.1-1.0 microgram) was also significantly increased after subcutaneous administration of this dose of captopril, whereas that in response to either histamine (2-20 micrograms) or prostaglandin E2 (2 micrograms) was unchanged. The pain threshold of the paw, injected with carrageenin (1 microgram) was lowered significantly after subcutaneous administration of captopril (1 mg kg-1). Potentiation by captopril (1 mg kg-1, s.c.) of paw swelling in response to intraplantar carrageenin (100 micrograms) or bradykinin (1 microgram) was reduced by prior subcutaneous administration of indomethacin (5 mg kg-1). It is suggested that normally, tissue kininase II activity is sufficient to decrease the inflammatory response of the hind paw to carrageenin or bradykinin. After inhibition of kininase II with captopril, bradykinin levels are increased and interact with concomitantly released prostaglandins to potentiate inflammation.

journal_name

Br J Pharmacol

journal_title

British journal of pharmacology

authors

Boura AL,Svolmanis AP

doi

10.1111/j.1476-5381.1984.tb16435.x

subject

Has Abstract

pub_date

1984-05-01 00:00:00

pages

3-8

issue

1

eissn

0007-1188

issn

1476-5381

journal_volume

82

pub_type

杂志文章

相关文献

BRITISH JOURNAL OF PHARMACOLOGY文献大全
  • Effects of acute treatment with paroxetine, citalopram and venlafaxine in vivo on noradrenaline and serotonin outflow: a microdialysis study in Swiss mice.

    abstract：:1. This study investigated whether a single administration of a range of doses (1, 4 and 8 mg kg-1, i.p.) of paroxetine, citalopram or venlafaxine may simultaneously increase extracellular levels of 5-HT ([5-HT]ext) and noradrenaline ([NA]ext) by using in vivo microdialysis in the frontal cortex (FCx) of awake, freely...

    journal_title：British journal of pharmacology

    pub_type： 杂志文章

    doi：10.1038/sj.bjp.0705538

    authors： David DJ,Bourin M,Jego G,Przybylski C,Jolliet P,Gardier AM

    更新日期：2003-11-01 00:00:00

  • Adenosine potentiates immunological histamine release from rat mast cells by a novel cyclic AMP-independent cell-surface action.

    abstract：:Adenosine enhanced histamine release and prolonged the adenosine 3':5'-cyclic monophosphate (cyclic AMP) response in purified rat peritoneal mast cells following immunological challenge. The effect on the cyclic AMP response, which was blocked by 8-phenyltheophylline, probably results from an interaction with A2-purin...

    journal_title：British journal of pharmacology

    pub_type： 杂志文章

    doi：10.1111/j.1476-5381.1985.tb08823.x

    authors： Church MK,Hughes PJ

    更新日期：1985-05-01 00:00:00

  • Augmentation of allergic inflammation in prostanoid IP receptor deficient mice.

    abstract：:1 To evaluate the role of prostaglandin I(2) (PGI(2)) in allergic inflammation, allergic responses in the airway, skin and T cells were studied in mice lacking the receptor for PGI(2) (the prostanoid IP receptor) through gene disruption. 2 Three inhalations of antigen caused an increase in plasma extravasation, leukoc...

    journal_title：British journal of pharmacology

    pub_type： 杂志文章

    doi：10.1038/sj.bjp.0704872

    authors： Takahashi Y,Tokuoka S,Masuda T,Hirano Y,Nagao M,Tanaka H,Inagaki N,Narumiya S,Nagai H

    更新日期：2002-10-01 00:00:00

  • Effect of vasoactive peptides on prostacyclin synthesis in man.

    abstract：:Bradykinin, angiotensin II, arginine vasopressin (AVP) or des-amino-D-arginine vasopressin (DDAVP) were administered by intravenous infusion to 10 healthy men. The concentration of 6-oxo-prostaglandin F1 alpha (6-oxo-PGF1 alpha), the stable hydrolysis product of prostacyclin (PGI2), was measured in plasma using gas ch...

    journal_title：British journal of pharmacology

    pub_type： 杂志文章

    doi：10.1111/j.1476-5381.1986.tb10177.x

    authors： Barrow SE,Dollery CT,Heavey DJ,Hickling NE,Ritter JM,Vial J

    更新日期：1986-01-01 00:00:00

  • Selective inhibition of human inducible nitric oxide synthase by S-alkyl-L-isothiocitrulline-containing dipeptides.

    abstract：:The aim of this study was to investigate the structure-activity relationship of S-alkyl-L-isothiocitrulline-containing dipeptides towards three partially purified recombinant human nitric oxide synthase (NOS) isozymes, as well as the effects of these compounds on cytokine-induced NO production by human DLD-1 cells. In...

    journal_title：British journal of pharmacology

    pub_type： 杂志文章

    doi：10.1038/sj.bjp.0704023

    authors： Park JM,Higuchi T,Kikuchi K,Urano Y,Hori H,Nishino T,Aoki J,Inoue K,Nagano T

    更新日期：2001-04-01 00:00:00

  • The effect of p-chloromercuribenzoate on structure-binding relationships of muscarinic receptors in the rat cerebral cortex.

    abstract：:Muscarinic receptors in the rat cerebral cortex, reacted with p-chloromercuribenzoate (PCMB) under different conditions (Phase I and II), have modified binding sites. These exhibit remarkable changes in the structural dependence of the binding of drugs. In Phase I, the structure-binding profile of agonists for both th...

    journal_title：British journal of pharmacology

    pub_type： 杂志文章

    doi：10.1111/j.1476-5381.1983.tb11066.x

    authors： Birdsall NJ,Burgen AS,Hulme EC,Wong EH

    更新日期：1983-09-01 00:00:00

  • The cholinergic properties of some amino-acid esters and amides.

    abstract：:1. Several amino-acid esters and amides have been prepared and their toxicological and pharmacological properties have been investigated. Some of the quaternary esters and amides were lethal to mice at doses below 1 mg/kg; this lethality was usually associated with high nicotinic activity. None of the compounds showed...

    journal_title：British journal of pharmacology

    pub_type： 杂志文章

    doi：10.1111/j.1476-5381.1968.tb07056.x

    authors： Barrass BC,Brimblecombe RW,Parkes DC,Rich P

    更新日期：1968-10-01 00:00:00

  • Effects of glyceryl trinitrate and SIN-1A on musculature and vasculature of the dog trachea in situ.

    abstract：:In dog trachea in situ, perfused arterially with blood, isoprenaline, glyceryl trinitrate and N-nitroso-N-morpholinoamino-acetonitrile (SIN-1A) given intra-arterially, decreased tracheal tone which had been elevated by neostigmine and increased tracheal blood flow. Glyceryl trinitrate and SIN-1A were more effective on...

    journal_title：British journal of pharmacology

    pub_type： 杂志文章

    doi：10.1111/j.1476-5381.1981.tb16764.x

    authors： Maruyama M,Satoh K,Taira N

    更新日期：1981-05-01 00:00:00

  • Enhanced reduction of myocardial infarct size by combined ACE inhibition and AT(1)-receptor antagonism.

    abstract：:The effects of the angiotensin-converting-enzyme inhibitor (ACEI) ramiprilat, the angiotensin II type 1 receptor antagonist (AT(1)A) candesartan, and the combination of both drugs on infarct size (IS) resulting from regional myocardial ischaemia were studied in pigs. Both ACEI and AT(1)A reduce myocardial IS by a brad...

    journal_title：British journal of pharmacology

    pub_type： 杂志文章

    doi：10.1038/sj.bjp.0703544

    authors： Weidenbach R,Schulz R,Gres P,Behrends M,Post H,Heusch G

    更新日期：2000-09-01 00:00:00

  • Uptake and inactivation of prostaglandin E2 methyl analogues in the rat pulmonary circulation.

    abstract：:1 The fate of (15S)-15-methyl prostaglandin E(2) methyl ester and 16,16-dimethyl prostaglandin E(2) in the pulmonary circulation of rat isolated lungs was compared with that of prostaglandin E(2) by means of bioassay.2 Calculated on the basis of height of response of the assay tissues, the inactivation of prostaglandi...

    journal_title：British journal of pharmacology

    pub_type： 杂志文章

    doi：10.1111/j.1476-5381.1978.tb08456.x

    authors： Bakhle YS,Jancar S,Whittle BJ

    更新日期：1978-02-01 00:00:00

  • Differential inhibition by adenosine or by prostaglandin E1 of human platelet aggregation induced by adenosine 5'-O-(1-thiodiphosphate) and adenosine 5'-O-(2-thiodiphosphate).

    abstract：:Adenosine 5'-diphosphate (ADP) induces human platelet aggregation and inhibits stimulated adenylate cyclase. Adenosine 5'-O-(1-thiodiphosphate) (ADP-alpha-S) and adenosine 5'-O-(2-thiodiphosphate) (ADP-beta-S) act at the ADP receptor and achieve the same maximal rate of human platelet aggregation as each other. Adenos...

    journal_title：British journal of pharmacology

    pub_type： 杂志文章

    doi：10.1111/j.1476-5381.1982.tb08781.x

    authors： Cusack NJ,Hourani SM

    更新日期：1982-02-01 00:00:00

  • Effects of moderate hypoxia, hypercapnia and acidosis on haemodynamic changes induced by endothelin-1 in the pithed rat.

    abstract：:1. Pithed rats were respired at a fixed rate of 54 cycles min-1 and with a ventilation volume of either 20 (control) or 10 ml kg-1. In these two preparations, the dose-response relationships for the systemic blood pressure responses to endothelin-1, administered i.v., were examined. Also, cardiac output, its distribut...

    journal_title：British journal of pharmacology

    pub_type： 杂志文章

    doi：10.1111/j.1476-5381.1989.tb14638.x

    authors： MacLean MR,Randall MD,Hiley CR

    更新日期：1989-11-01 00:00:00

  • Effect of curcumin on cell cycle progression and apoptosis in vascular smooth muscle cells.

    abstract：:1. The possible mechanisms of the antiproliferative and apoptotic effects of curcumin (diferuloylmethane), a polyphenol in the spice turmeric, on vascular smooth muscle cells were studied in rat aortic smooth muscle cell line (A7r5). 2. The proliferative response was determined from the uptake of [3H]-thymidine. Curcu...

    journal_title：British journal of pharmacology

    pub_type： 杂志文章

    doi：10.1038/sj.bjp.0701914

    authors： Chen HW,Huang HC

    更新日期：1998-07-01 00:00:00

  • Differential modulation of voltage-activated conductances by intracellular and extracellular cyclic nucleotides in leech salivary glands.

    abstract：:1. Two-electrode voltage clamp was used to study the effects of adenosine 3':5'-cyclic monophosphate (cyclic AMP) and guanosine 3':5'-cyclic monophosphate (cyclic GMP) on voltage-dependent ion channels in salivary gland cells of the leech, Haementeria ghilianii. 2. Intracellular cyclic AMP specifically blocked delayed...

    journal_title：British journal of pharmacology

    pub_type： 杂志文章

    doi：10.1111/j.1476-5381.1995.tb16673.x

    authors： Everill B,Berry MS

    更新日期：1995-09-01 00:00:00

  • Aldosterone does not mediate angiotensin II-induced atherosclerosis and abdominal aortic aneurysms.

    abstract：:We have demonstrated previously that infusion of angiotensin II (AngII) into hyperlipidemic mice augments atherosclerosis and results in the formation of abdominal aortic aneurysms (AAA). The purpose of this study was to determine the role of aldosterone in these AngII-induced vascular pathologies. Male apolipoprotein...

    journal_title：British journal of pharmacology

    pub_type： 杂志文章

    doi：10.1038/sj.bjp.0706098

    authors： Cassis LA,Helton MJ,Howatt DA,King VL,Daugherty A

    更新日期：2005-02-01 00:00:00

  • Discrimination by benextramine between the NPY-Y1 receptor subtypes present in rabbit isolated vas deferens and saphenous vein.

    abstract：:1. In order to characterize the neuropeptide Y (NPY) Y1 receptors known to be present in rabbit isolated vas deferens and saphenous vein, the pharmacological activity of the selective NPY Y1 receptor agonists, [Leu31,Pro34] NPY and various other peptide agonists, together with the putative NPY antagonist, benextramine...

    journal_title：British journal of pharmacology

    pub_type： 杂志文章

    doi：10.1111/j.1476-5381.1995.tb16311.x

    authors： Palea S,Corsi M,Rimland JM,Trist DG

    更新日期：1995-05-01 00:00:00

  • Enhancement of inflammatory mediator release by beta(2)-adrenoceptor agonists in airway epithelial cells is reversed by glucocorticoid action.

    abstract：BACKGROUND AND PURPOSE:Due to their potent bronchodilator properties, beta(2)-adrenoceptor agonists are a mainstay of therapy in asthma. However, the effects of beta(2)-adrenoceptor agonists on inflammation are less clear. Accordingly, we have investigated the effects of beta(2)-adrenoceptor agonists on inflammatory me...

    journal_title：British journal of pharmacology

    pub_type： 杂志文章

    doi：10.1111/j.1476-5381.2010.00708.x

    authors： Holden NS,Rider CF,Bell MJ,Velayudhan J,King EM,Kaur M,Salmon M,Giembycz MA,Newton R

    更新日期：2010-05-01 00:00:00

  • Acetylcholine and tachykinins involvement in the caffeine-induced biphasic change in intracellular Ca2+ in bovine airway smooth muscle.

    abstract：:1. Caffeine has been widely used as a pharmacological tool to evaluate Ca(2+) release from the sarcoplasmic reticulum in isolated smooth muscle cells. However, in nervous tissue this drug also causes neurotransmitters release, which might cause additional effects when smooth muscle strips are evaluated. To assess this...

    journal_title：British journal of pharmacology

    pub_type： 杂志文章

    doi：10.1038/sj.bjp.0705348

    authors： Montaño LM,Carbajal V,Arreola JL,Barajas-López C,Flores-Soto E,Vargas MH

    更新日期：2003-07-01 00:00:00

  • Exogenous cholecystokinin-8 reduces vagal efferent nerve activity in rats through CCK(A) receptors.

    abstract：:It has been proposed that the vagus nerve plays a role in mediating cholecystokinin-8 (CCK-8) effect on such gastric functions as motility, emptying and gastric acid secretion. To examine the contribution of the efferent pathways in realizing these effects, efferent mass activity in the ventral gastric vagal nerve in ...

    journal_title：British journal of pharmacology

    pub_type： 杂志文章

    doi：10.1038/sj.bjp.0703270

    authors： Bucinskaite V,Kurosawa M,Lundeberg T

    更新日期：2000-04-01 00:00:00

  • Effects of hydrogen sulphide on motility patterns in the rat colon.

    abstract：BACKGROUND AND PURPOSE:Hydrogen sulphide (H2 S) is an endogenous gaseous signalling molecule with putative functions in gastrointestinal motility regulation. Characterization of H2 S effects on colonic motility is crucial to establish its potential use as therapeutic agent in the treatment of colonic disorders. EXPERI...

    journal_title：British journal of pharmacology

    pub_type： 杂志文章

    doi：10.1111/bph.12100

    authors： Gil V,Parsons S,Gallego D,Huizinga J,Jimenez M

    更新日期：2013-05-01 00:00:00

  • Effects of noradrenaline and carbachol on temperature regulation of rats.

    abstract：:1 Noradrenaline (0.2 to 20 micrograms) and carbachol (0.1 to 1 microgram) injected into the preoptic/anterior hypothalamic area, evoked dose-dependent falls in core temperature at all sites tested, followed in most experiments by delayed increases that were not dose-related. Muscarine (0.1 to 10 microgram) produced ef...

    journal_title：British journal of pharmacology

    pub_type： 杂志文章

    doi：10.1111/j.1476-5381.1979.tb17332.x

    authors： Poole S,Stephenson JD

    更新日期：1979-01-01 00:00:00

  • Paracetamol is a centrally acting analgesic using mechanisms located in the periaqueductal grey.

    abstract：BACKGROUND AND PURPOSE:We previously demonstrated that paracetamol has to be metabolised in the brain by fatty acid amide hydrolase enzyme into AM404 (N-(4-hydroxyphenyl)-5Z,8Z,11Z,14Z-eicosatetraenamide) to activate CB1 receptors and TRPV1 channels, which mediate its analgesic effect. However, the brain mechanisms sup...

    journal_title：British journal of pharmacology

    pub_type： 杂志文章

    doi：10.1111/bph.14934

    authors： Barrière DA,Boumezbeur F,Dalmann R,Cadeddu R,Richard D,Pinguet J,Daulhac L,Sarret P,Whittingstall K,Keller M,Mériaux S,Eschalier A,Mallet C

    更新日期：2020-04-01 00:00:00

  • The relation of adenyl cyclase to the activity of other ATP utilizing enzymes and phosphodiesterase in preparations of rat brain; mechanism of stimulation of cyclic AMP accumulation by adrenaline, ouabain and Mn++.

    abstract：:1. The mechanism of stimulation of cyclic adenosine 3',5'-monophosphate (cyclic AMP) accumulation by adrenaline and ouabain and the effect of Mn(++) substitution for Mg(++) as the metal ion requirement of this system was studied in cell-free preparations of adenyl cyclase from rat brain.2. In the rat cerebral cortex p...

    journal_title：British journal of pharmacology

    pub_type： 杂志文章

    doi：10.1111/j.1476-5381.1973.tb08358.x

    authors： Katz S,Tenenhouse A

    更新日期：1973-07-01 00:00:00

  • Contribution of cytochrome P450 metabolites to bradykinin-induced vasodilation in endothelial NO synthase deficient mouse hearts.

    abstract：:We have characterized the contribution of endothelial nitric oxide synthase (eNOS), cyclo-oxygenase (COX) and cytochrome P450 (CYP450) to the bradykinin (BK)- induced vasodilation in isolated hearts from wildtype (WT) and eNOS deficient mice (eNOS-/-). The endothelium-dependent vasodilation by bradykinin (BK, 1 microM...

    journal_title：British journal of pharmacology

    pub_type： 杂志文章

    doi：10.1038/sj.bjp.0704472

    authors： Ding Z,Gödecke A,Schrader J

    更新日期：2002-02-01 00:00:00

  • Effect of nicotine on the formation of prostacyclin-like activity and thromboxane in rabbit aorta and platelets.

    abstract：:The effect of nicotine on the bioformation of prostacyclin (PGI2) and of thromboxane (Tx)B2 in rabbit aorta and platelets, respectively, was investigated. Rabbit aortic rings were incubated with [14C]-arachidonic acid ( [14C]-AA) and the incubation products were separated with thin layer chromatography (t.l.c.). Alter...

    journal_title：British journal of pharmacology

    pub_type： 杂志文章

    doi：10.1111/j.1476-5381.1984.tb10743.x

    authors： Alster P,Wennmalm A

    更新日期：1984-01-01 00:00:00

  • The effects of alpha 2-adrenoceptor antagonists on the inhibition of 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI)-induced head shakes by 5-HT1A receptor agonists in the mouse.

    abstract：:1. 8-Hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT), gepirone, buspirone and ipsapirone dose-dependently antagonized the head-shakes induced by 1-(2,5-dimethoxy 4-iodophenyl)-2-amino propane hydrochloride (DOI) (1.0 mg kg-1) in mice, when these agents were given i.p. 10 min beforehand. 2. para-Chlorophenylalanine (...

    journal_title：British journal of pharmacology

    pub_type： 杂志文章

    doi：10.1111/j.1476-5381.1993.tb13727.x

    authors： Dursun SM,Handley SL

    更新日期：1993-08-01 00:00:00

  • Relaxation to authentic nitric oxide and SIN-1 in rat isolated mesenteric arteries: variable role for smooth muscle hyperpolarization.

    abstract：:Authentic nitric oxide (NO; 0.1 - 10 micromoles) caused transient, dose-dependent relaxation of phenylephrine-induced tone without changing membrane potential in mesenteric arteries. Larger doses, above 10 micromoles, did not evoke more relaxation (maximal relaxation to 150 micromoles NO in denuded arteries, 69+/-7%, ...

    journal_title：British journal of pharmacology

    pub_type： 杂志文章

    doi：10.1038/sj.bjp.0704127

    authors： Plane F,Sampson LJ,Smith JJ,Garland CJ

    更新日期：2001-07-01 00:00:00

  • Anaphylactic bronchoconstriction in BP2 mice: interactions between serotonin and acetylcholine.

    abstract：:1. Immunized BP2 mice developed an acute bronchoconstriction in vivo and airway muscle contraction in vitro in response to ovalbumin (OA) and these contractions were dose dependent. 2. Methysergide or atropine inhibited OA-induced bronchoconstriction in vivo and airway muscle contraction in vitro. 3. Neostigmine poten...

    journal_title：British journal of pharmacology

    pub_type： 杂志文章

    doi：10.1038/sj.bjp.0702304

    authors： Eum SY,Norel X,Lefort J,Labat C,Vargaftig BB,Brink C

    更新日期：1999-01-01 00:00:00

  • Rat vas deferens: a specific bioassay for endogenous opioid peptides.

    abstract：:The electrically-evoked contractions of the rat vas deferens were selectively inhibited by beta-endorphin, the preparation being much less sensitive to enkephalins and narcotic analgesic drugs. However, introduction of D-Ala in position 2 of [Leu]-enkephalin enhanced the activity of the opioid peptide to the order of ...

    journal_title：British journal of pharmacology

    pub_type： 杂志文章

    doi：10.1111/j.1476-5381.1978.tb08653.x

    authors： Lemaire S,Magnan J,Regoli D

    更新日期：1978-11-01 00:00:00

  • Human podocytes express functional thermosensitive TRPV channels.

    abstract：BACKGROUND AND PURPOSE:Heat-sensitive transient receptor potential vanilloid (TRPV) channels are expressed in various epithelial tissues regulating, among else, barrier functions. Their expression is well established in the distal nephron; however, we have no data about their presence in podocytes. As podocytes are ind...

    journal_title：British journal of pharmacology

    pub_type： 杂志文章

    doi：10.1111/bph.14052

    authors： Ambrus L,Kelemen B,Szabó T,Bíró T,Tóth BI

    更新日期：2017-12-01 00:00:00