Effect of nicotine on the formation of prostacyclin-like activity and thromboxane in rabbit aorta and platelets.

abstract：:1. Neural crest material from neurula stage Xenopus embryos was tissue cultured as small aggregates of cells or a single cell suspension. Isolated pigment cells differentiated after 2 days in culture. 2. Melatonin (10(-15) to 10(-13) M) induced pigment granule condensation; it was 10,000 times more effective than any ...

journal_title：British journal of pharmacology

authors： Messenger EA,Warner AE

更新日期：1977-12-01 00:00:00

abstract：:1. Superoxide dismutase (SOD, 60 u ml-1) or ferricytochrome c (70 microM) significantly inhibited thrombin-stimulated platelet adhesion to gelatin-coated plastic, whereas catalase (1000 u ml-1) or mannitol (1 mM) had no effect. 2. The platelet aggregation induced by low concentrations of thrombin (causing less than 45...

journal_title：British journal of pharmacology

authors： Salvemini D,de Nucci G,Sneddon JM,Vane JR

更新日期：1989-08-01 00:00:00

abstract：:1. The single-channel current recording technique has been used to investigate the effects of cromakalim, diazoxide and ATP, separately and combined, on the opening of ATP-sensitive potassium channels in the insulin-secreting cell-line RINm5F. The actions of these drugs have been studied using the permeabilized open-c...

journal_title：British journal of pharmacology

authors： Dunne MJ,Aspinall RJ,Petersen OH

更新日期：1990-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Pemphigus and pemphigoid diseases are characterized and caused predominantly by IgG autoantibodies targeting structural proteins of the skin. Their current treatment relies on general and prolonged immunosuppression that causes severe adverse events, including death. Hence, novel safe and more ef...

journal_title：British journal of pharmacology

authors： Kasprick A,Hofrichter M,Smith B,Ward P,Bieber K,Shock A,Ludwig RJ,Schmidt E

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:In humans and non-human primates, the 7TM receptor GPR17 exists in two isoforms differing only by the length of the N-terminus. Of these, only the short isoform has previously been characterized. Hence, we investigated gene expression and ligand-binding profiles of both splice variants and furthe...

journal_title：British journal of pharmacology

authors： Benned-Jensen T,Rosenkilde MM

更新日期：2010-03-01 00:00:00

abstract：:The neurotoxin MPP+ potently inhibited the striatal binding of [3H]-tyramine, a putative marker for the vesicular transporter of dopamine, and provoked a massive in vivo release of striatal dopamine. Tetrabenazine, an established ligand for the vesicular catecholamine carrier, potently inhibited [3H]-tyramine binding,...

journal_title：British journal of pharmacology

authors： Vaccari A,Del Zompo M,Melis F,Gessa GL,Rossetti ZL

更新日期：1991-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Cytochrome P450 (CYP, P450) 3A4 is involved in the metabolism of 50% of drugs and its catalytic activity in vivo is not explained only by hepatic expression levels. We previously demonstrated that UDP-glucuronosyltransferase (UGT) 2B7 suppressed CYP3A4 activity through an interaction. In the pres...

journal_title：British journal of pharmacology

authors： Miyauchi Y,Tanaka Y,Nagata K,Yamazoe Y,Mackenzie PI,Yamada H,Ishii Y

更新日期：2020-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:This paper is intended to assist pharmacologists to make the most of statistical analysis and in avoid common errors. APPROACH:A scenario is presented where an experimenter performed an experiment to test the effects of two drugs on cultured cells. Analysis of the results, expressed as percentag...

journal_title：British journal of pharmacology

authors： Lew M

更新日期：2007-10-01 00:00:00

abstract：:1. The alpha 2-adrenoceptor binding sites of rabbit spleen and rat kidney, labelled with [3H]-rauwolscine, were characterized using a range of subtype selective ligands. 2. In rabbit spleen, the alpha-2-adrenoceptor binding sites displayed high affinity for oxymetazoline and WB 4101 and low affinity for prazosin and c...

journal_title：British journal of pharmacology

authors： Michel AD,Loury DN,Whiting RL

更新日期：1990-03-01 00:00:00

abstract：AIMS:The trace amine-associated receptor (Taar) family displays high species- and subtype-specific pharmacology. Several trace amines such as β-phenylethylamine (β-PEA), p-tyramine and tryptamine are agonists at TA(1) but poorly activate rat and mouse Taar4. PRINCIPAL RESULTS:Using rat TA(1) and Taar4 chimera, we id...

journal_title：British journal of pharmacology

authors： Stäubert C,Bohnekamp J,Schöneberg T

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:There is increasing evidence that angiotensin II (Ang II) is associated with the occurrence of ventricular arrhythmias. However, little is known about the electrophysiological effects of Ang II on ventricular repolarization. The rapid component of the delayed rectifier K(+) current (I(Kr)) plays ...

journal_title：British journal of pharmacology

authors： Wang YH,Shi CX,Dong F,Sheng JW,Xu YF

更新日期：2008-05-01 00:00:00

abstract：:1. Mild stress plus mild pain (solvent injection) applied daily to neonatal mice induces hormonal, behavioural and metabolic changes perduring in the adult life. 2. We investigated whether daily mild stress to neonatal mice induces also long-term defined changes of immune response, and whether immune changes are preve...

journal_title：British journal of pharmacology

authors： Loizzo A,Loizzo S,Lopez L,d'Amore A,Renzi P,Spampinato S,Di Carlo S,Bacosi A,Zuccaro P,Pacifici R

更新日期：2002-03-01 00:00:00

abstract：:1. Measurements were made of the in vivo formation of inositol phosphates in the brains of C57/B1/601a mice treated acutely or chronically with lithium chloride (LiCl). 2. A single injection of LiCl (10 mEquiv kg-1, s.c.) 18 h before death increased the accumulation of [3H]-inositol phosphates ([3H]-Ins P's) in the br...

journal_title：British journal of pharmacology

authors： Whitworth P,Heal DJ,Kendall DA

更新日期：1990-09-01 00:00:00

abstract：:The last five years have witnessed a remarkable resurgence of interest in myocardial reperfusion injury. Reperfusion is absolutely essential to salvage ischaemic myocardium but experimental and clinical studies show that reperfusion-associated injury may mask the full benefits of prompt reperfusion in acute myocardial...

journal_title：British journal of pharmacology

authors： Baxter GF,Burley DS

更新日期：2008-01-01 00:00:00

abstract：:To characterize the volume-sensitive, osmolyte permeable anion channels responsible for the osmodependent release of taurine from supraoptic nucleus (SON) astrocytes, we investigated the pharmacological properties of the [(3)H]-taurine efflux from acutely isolated SON. Taurine release induced by hypotonic stimulus (25...

journal_title：British journal of pharmacology

authors： Brès V,Hurbin A,Duvoid A,Orcel H,Moos FC,Rabié A,Hussy N

更新日期：2000-08-01 00:00:00

abstract：:The NADPH oxidase (NOX) family of enzymes produces ROS as their sole function and is becoming recognized as key modulators of signal transduction pathways with a physiological role under acute stress and a pathological role after excessive activation under chronic stress. The seven isoforms differ in their regulation,...

journal_title：British journal of pharmacology

authors： Teixeira G,Szyndralewiez C,Molango S,Carnesecchi S,Heitz F,Wiesel P,Wood JM

更新日期：2017-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Voltage-operated sodium channels constitute major target sites for local anaesthetic-like action. The clinical use of local anaesthetics is still limited by severe side effects, in particular, arrhythmias and convulsions. These side effects render the search for new local anaesthetics a matter of...

journal_title：British journal of pharmacology

authors： Haeseler G,Karst M,Foadi N,Gudehus S,Roeder A,Hecker H,Dengler R,Leuwer M

更新日期：2008-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The bladder urothelium is now known to have active properties. Our aim was to investigate the contractile properties of the urinary mucosa in response to the tachykinin neurokinin A (NKA) and carbachol. EXPERIMENTAL APPROACH:Discrete concentration-response curves for carbachol and NKA were obtai...

journal_title：British journal of pharmacology

authors： Sadananda P,Chess-Williams R,Burcher E

更新日期：2008-04-01 00:00:00

abstract：:1. The relaxant effects of Zeneca ZD7114, BRL37344 (putative beta 3-adrenoceptor agonists) and various phenylethylamine-based agonists were studied in isolated ileum of the rat where tone was increased with carbachol (0.5 microM). Agonist-induced relaxation.was measured under equilibrium conditions with alpha-, beta 1...

journal_title：British journal of pharmacology

authors： Growcott JW,Holloway B,Green M,Wilson C

更新日期：1993-12-01 00:00:00

abstract：:1. Adenosine 5'-triphosphate (ATP) is known to augment cardiac contractile activity and cause an increase in intracellular Ca(2+) concentration ([Ca(2+)](i)) in isolated cardiomyocytes. However, no information regarding the ATP-mediated signal transduction in the myocardium in congestive heart failure (CHF) is availab...

journal_title：British journal of pharmacology

authors： Saini HK,Shao Q,Musat S,Takeda N,Tappia PS,Dhalla NS

更新日期：2005-01-01 00:00:00

abstract：:AMPA-type glutamate receptors are one of the most dynamic components of excitatory synapses. Their regulated addition and removal from synapses leads to long-lasting forms of synaptic plasticity, known as long-term potentiation (LTP) and long-term depression (LTD). In addition, AMPA receptors reach their synaptic targ...

journal_title：British journal of pharmacology

authors： Esteban JA

更新日期：2008-03-01 00:00:00

abstract：:1. Plasma, peripheral and thoracic lymph concentrations of penicillin V, phenethicillin, carbenicillin, ampicillin, cloxacillin, penicillin G, chloramphenicol and sulphadiazine were determined at various time intervals up to 6 h following intramuscular administration of 50 mg/kg to dogs.2. Peak plasma concentrations o...

journal_title：British journal of pharmacology

authors： Acred P,Brown DM,Clark BF,Mizen L

更新日期：1970-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Next to its broad antimicrobial spectrum, the therapeutic advantages of the fluoroquinolone antimicrobial drug Danofloxacin-Mesylate (DM) are attributed to its rapid distribution to the major target tissues such as lungs, intestines and the mammary gland in animals. Previous analyses revealed tha...

journal_title：British journal of pharmacology

authors： Schrickx JA,Fink-Gremmels J

更新日期：2007-02-01 00:00:00

abstract：:In non-allergic subjects, histamine induced a reduction of minimal nasal cross-sectional area (Amin) and an increase in albumin release into nasal lavage. The effect of histamine on albumin release was inhibited by pretreatment with NG-nitro-L-arginine methyl ester (L-NAME), 1 mumol but not by D-NAME, 1 mumol. L-NAME,...

journal_title：British journal of pharmacology

authors： Dear JW,Scadding GK,Foreman JC

更新日期：1995-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Suramin is a clinically prescribed drug for treatment of human African trypanosomiasis, cancer and infection. It is also a well-known pharmacological antagonist of P2 purinoceptors. Despite its clinical use and use in research, the biological actions of this molecule are still incompletely unders...

journal_title：British journal of pharmacology

authors： Chi Y,Gao K,Zhang H,Takeda M,Yao J

更新日期：2014-07-01 00:00:00

abstract：:1. The aim of the present study was to explore the contribution of adrenergic, sensory and nitrergic innervations to the inhibitory effects of the beta2-adrenoceptor agonist clenbuterol on responses to electrical field stimulation (EFS, 200 mA, 0.3 ms, 1-16 Hz, for 30 s, at 1 min interval) in rat mesenteric artery seg...

journal_title：British journal of pharmacology

authors： Marín J,Balfagón G

更新日期：1998-06-01 00:00:00

abstract：:1. The mechanism of stimulation of cyclic adenosine 3',5'-monophosphate (cyclic AMP) accumulation by adrenaline and ouabain and the effect of Mn(++) substitution for Mg(++) as the metal ion requirement of this system was studied in cell-free preparations of adenyl cyclase from rat brain.2. In the rat cerebral cortex p...

journal_title：British journal of pharmacology

authors： Katz S,Tenenhouse A

更新日期：1973-07-01 00:00:00

abstract：:1. Neostigmine and BW284C51 induced concentration-dependent contractions in human isolated bronchial preparations whereas tetraisopropylpyrophosphoramide (iso-OMPA) was inactive on airway resting tone. 2. Neostigmine (0.1 microM) or iso-OMPA (100 microM) increased acetylcholine sensitivity in human isolated bronchial ...

journal_title：British journal of pharmacology

authors： Norel X,Angrisani M,Labat C,Gorenne I,Dulmet E,Rossi F,Brink C

更新日期：1993-04-01 00:00:00

abstract：:1. The effects of seven agonist and three antagonist adenosine receptor ligands were compared on the guinea-pig sinoatrial (SA) node (isolated right atrium) and atrioventricular (AV) node (perfused whole heart). Single agonist concentration-effect curves were obtained to 5'-N-ethylcarboxamidoadenosine (NECA), R(-)-N6-...

journal_title：British journal of pharmacology

authors： Meester BJ,Shankley NP,Welsh NJ,Wood J,Meijler FL,Black JW

更新日期：1998-06-01 00:00:00

abstract：:1. Although anti-alpha(4) integrin mAbs reduce eosinophil accumulation in several models of allergic inflammation, it is not clear whether this occurs via a direct action to block eosinophil alpha(4) integrins or indirectly on another cell type. The role of alpha(4) integrins on the accumulation of (111)In-labelled eo...

journal_title：British journal of pharmacology

authors： Teixeira MM,Robinson MK,Shock A,Hellewell PG

更新日期：2001-01-01 00:00:00