Exogenous cholecystokinin-8 reduces vagal efferent nerve activity in rats through CCK(A) receptors.

abstract：:1. The polymorphonuclear neutrophils (PMN) activation and mobilization observed in acute cerebral infarction contribute to the brain tissue damage, but PMN could also be involved in postischemic functional injury of ischemied blood vessel. 2. This study was undertaken to investigate whether pharmacological neutropenia...

journal_title：British journal of pharmacology

authors： Pétrault O,Ouk T,Gautier S,Laprais M,Gelé P,Bastide M,Bordet R

更新日期：2005-04-01 00:00:00

abstract：:We investigated the action of the phenylalkylamines verapamil and N-methyl-verapamil on the Kv1.3 potassium channel using the whole-cell configuration of the patch-clamp technique. Our goal was to identify their binding as a prerequisite for using the phenylalkylamines as small, well-defined molecular probes, not only...

journal_title：British journal of pharmacology

authors： Rauer H,Grissmer S

更新日期：1999-07-01 00:00:00

abstract：:Three genes encode the small-conductance Ca(2+)-activated K(+) channels (SK channels). We have stably expressed hSK1 and rSK2 in HEK 293 cells and addressed the pharmacology of these subtypes using whole-cell patch clamp recordings. The bee venom peptide apamin blocked hSK1 as well as rSK2 with IC(50) values of 3.3 nM...

journal_title：British journal of pharmacology

authors： Strøbaek D,Jørgensen TD,Christophersen P,Ahring PK,Olesen SP

更新日期：2000-03-01 00:00:00

abstract：:1. The pharmacological characteristics of cloned mammalian alpha 1A/D-, alpha 1B- and alpha 1C-adrenoceptor subtypes expressed in rat 1 fibroblasts were determined in comparison to the binding and functional properties of these subtypes in rat tissues. 2. Analysis of [3H]-prazosin binding to membrane homogenates from ...

journal_title：British journal of pharmacology

authors： Kenny BA,Naylor AM,Greengrass PM,Russell MJ,Friend SJ,Read AM,Wyllie MG

更新日期：1994-04-01 00:00:00

abstract：:1. The effects of cromakalim (BRL 34915) on the smooth muscle cells of guinea-pig mesenteric artery and vein were investigated with microelectrode and tension recording methods. 2. Cromakalim (greater than 10 microM) produced membrane hyperpolarization with an increase in ionic conductance. The hyperpolarization occur...

journal_title：British journal of pharmacology

authors： Nakao K,Okabe K,Kitamura K,Kuriyama H,Weston AH

更新日期：1988-11-01 00:00:00

abstract：UNLABELLED:Increasing evidence suggests that an overactive endocannabinoid system (ECS) may contribute to the development of diabetes by promoting energy intake and storage, impairing both glucose and lipid metabolism, by exerting pro-apoptotic effects in pancreatic beta cells and by facilitating inflammation in pancre...

journal_title：British journal of pharmacology

authors： Gruden G,Barutta F,Kunos G,Pacher P

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Mitochondria possess their own source of cAMP, that is, soluble adenylyl cyclase (sAC). Activation or expression of mitochondrial sAC promotes mitochondrial function. Oestrogen receptor signalling plays an essential role in the regulation of mitochondrial function. Here we aimed to determine whet...

journal_title：British journal of pharmacology

authors： Pozdniakova S,Guitart-Mampel M,Garrabou G,Di Benedetto G,Ladilov Y,Regitz-Zagrosek V

更新日期：2018-10-01 00:00:00

abstract：:1. Despite the observation of pharmacological responses to neuropeptide Y (NPY) in mammalian kidneys, there are species differences in the ease with which specific NPY binding sites can be demonstrated; we have investigated whether this can be explained by differential metabolism of NPY by a membrane-bound peptidase. ...

journal_title：British journal of pharmacology

authors： Price JS,Kenny AJ,Huskisson NS,Brown MJ

更新日期：1991-10-01 00:00:00

abstract：:The pharmacological activity of two natural bombesin-like peptides, alytesin and litorin, and 25 related synthetic peptides has been compared to that of bombesin. 2 The minimum length of the amino acid chain required for the first appearance of bombesin-like effects was represented by the C-terminal heptapeptide, and ...

journal_title：British journal of pharmacology

authors： Broccardo M,Falconieri Erspamer G,Melchiorri P,Negri L,de Castiglione R

更新日期：1975-10-01 00:00:00

abstract：:1. We have characterized the 5-hydroxytryptamine (5-HT)-induced calcium signalling in endothelial cells from the human pulmonary artery. Using RT-PCR we show, that of all cloned G-protein coupled 5-HT receptors, these cells express only 5-HT1D beta, 5-HT2B and little 5-HT4 receptor mRNA. 2. In endothelial cells 5-HT i...

journal_title：British journal of pharmacology

authors： Ullmer C,Boddeke HG,Schmuck K,Lübbert H

更新日期：1996-03-01 00:00:00

abstract：:1. Human epicardial coronary artery rings, freshly obtained from cardiac transplant patients, were examined for their responses to endothelium-derived relaxing factor (EDRF)-releasing agents. 2. Functional antagonism profoundly influenced relaxation responses in this tissue. Increasing force with concentrations of U46...

journal_title：British journal of pharmacology

authors： Stork AP,Cocks TM

更新日期：1994-12-01 00:00:00

abstract：:1. In the zymosan rat air pouch model of inflammation we have assessed the time dependence of phospholipase A2 (PLA2) accumulation in the inflammatory exudates as well as cell migration, myeloperoxidase activity, prostaglandin E2 (PGE2) and leukotriene B4 (LTB4) levels. 2. A significant increase in PLA2 activity was d...

journal_title：British journal of pharmacology

authors： Payá M,Terencio MC,Ferrándiz ML,Alcaraz MJ

更新日期：1996-04-01 00:00:00

abstract：:1. Desensitization of the myocardial beta-adrenergic signal transduction pathway is an important mechanism which is involved in the progression of hypertensive heart disease. The aim of the present study was to evaluate the differential effects of chronic pharmacotherapy with an angiotensin converting enzyme (ACE)-inh...

journal_title：British journal of pharmacology

authors： Zolk O,Flesch M,Schnabel P,Teisman AC,Pinto YM,van Gilst WH,Paul M,Böhm M

更新日期：1998-02-01 00:00:00

abstract：:1. The pulmonary vasculature is constantly exposed to oxygen and reactive oxygen species such as nitric oxide (NO) and superoxide anions which can combine at a near diffusion limited rate, to form the powerful, oxidant, peroxynitrite (ONOO-). When formed in large amounts, ONOO- is thought to contribute to tissue injur...

journal_title：British journal of pharmacology

authors： Chabot F,Mitchell JA,Quinlan GJ,Evans TW

更新日期：1997-06-01 00:00:00

abstract：:1 A rat isolated gastric mucosal preparation was used to monitor histamine output and acid secretion during stimulation by different secretagogues. 2 In non-stimulated preparations, spontaneous histamine output decreased over 450 min. 3 Stimulation of secretion with 4 (5)-methylhistamine or dibutyryl cyclic adenosine ...

journal_title：British journal of pharmacology

authors： Main IH,Pearce JB

更新日期：1982-05-01 00:00:00

abstract：:1 The actions of prostaglandin F2 alpha (PGF2 alpha) and noradrenaline on contraction and 45Ca exchange have been studied in rat mesenteric arteries. 2 PGF2 alpha and noradrenaline contracted rat isolated mesenteric artery preparations to about the same extent. The PGF2 alpha-stimulated contractions, unlike those prod...

journal_title：British journal of pharmacology

authors： Godfraind T,Miller RC

更新日期：1982-01-01 00:00:00

abstract：:1. Alprenolol, a beta-adrenoceptor blocking drug reported to have the same potency as propranolol in vitro and in vivo, was found to be four times more active than procaine as a local anaesthetic on frog sciatic nerve.2. At doses of 0.125 mg/kg and above alprenolol protected anaesthetized guinea-pigs against ouabain-i...

journal_title：British journal of pharmacology

authors： Singh BN,Williams EM

更新日期：1970-04-01 00:00:00

abstract：:Expression of two isoforms of Rho-kinase (ROCK) and its functional role in the physiological control of smooth muscle contraction in the sheep ureter were investigated. Helical strips of the ureteric smooth muscle were stimulated by electrical field stimulation (EFS, 60 V, 1 mS, 2, 4, 8, 16 and 32 Hz, for 20 S), KCl (...

journal_title：British journal of pharmacology

authors： Levent A,Büyükafsar K

更新日期：2004-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Histone deacetylase 6 (HDAC6) and silent information regulator 2 (SIRT2) control the dynamics of the microtubule network via their deacetylase activities. Tubulin polymerization promoting protein (TPPP/p25) enhances microtubule acetylation by its direct binding to HDAC6. Our objective was to char...

journal_title：British journal of pharmacology

authors： Mangas-Sanjuan V,Oláh J,Gonzalez-Alvarez I,Lehotzky A,Tőkési N,Bermejo M,Ovádi J

更新日期：2015-02-01 00:00:00

abstract：:1. The receptor for glucagon-like peptide-1 (GLP-1) can be activated by both its physiological hormone and a peptide discovered in the venom of the Gila Monster, exendin-4, which shows promise as an antidiabetic agent. 2. Exendin-4 displays receptor-binding properties not observed for GLP-1. Firstly, exendin-4 can be ...

journal_title：British journal of pharmacology

authors： Al-Sabah S,Donnelly D

更新日期：2003-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Cholecystokinin (CCK) stimulates the release of amylase and lipase from the normal pancreas. However, it is not clear to what extent this occurs in the early stages of pancreatitis induced by biliary tract obstruction in the rat and whether CCK initiates an inflammatory cascade in this condition....

journal_title：British journal of pharmacology

authors： Barrett TD,Yan W,Freedman JM,Lagaud GJ,Breitenbucher JG,Shankley NP

更新日期：2008-04-01 00:00:00

abstract：:We have investigated the effects of methylenedioxymethamphetamine (MDMA, 'ecstasy'), i.v., on diastolic blood pressure (DBP) in pithed and pentobarbitone anaesthetized rats. In pithed rats, the non-selective 5-HT receptor antagonist methiothepin (0.1 mg kg(-1)) and the alpha2-adrenoceptor antagonists methoxyidazoxan a...

journal_title：British journal of pharmacology

authors： McDaid J,Docherty JR

更新日期：2001-06-01 00:00:00

abstract：:Despite its long-standing reputation as a foul smelling and toxic gas that is associated with the decay of biological matter,hydrogen sulphide (H2S) has emerged as an important regulator of cardiovascular homoeostasis. H2S promotes a number of cellular signals that regulate metabolism, cardiac function and cell surviv...

journal_title：British journal of pharmacology

authors： Lefer DJ

更新日期：2008-11-01 00:00:00

abstract：:The aims of this study were to develop a technique to measure blood flow in the mouse ear and to investigate the nature of the vasodilator mediator(s) involved in the response to capsaicin. The response to capsaicin, applied topically, was investigated in anaesthetized CD1 or Sv129+C57BL/6 wild-type (+/+) or NK(1) rec...

journal_title：British journal of pharmacology

authors： Grant AD,Gerard NP,Brain SD

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:A functional link between seizure-induced P-glycoprotein overexpression at the blood-brain barrier and therapeutic failure has been suggested by several studies using rodent epilepsy models and human epileptic tissue. Recently, we reported that interference with the mechanisms that up-regulate P-...

journal_title：British journal of pharmacology

authors： Schlichtiger J,Pekcec A,Bartmann H,Winter P,Fuest C,Soerensen J,Potschka H

更新日期：2010-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:8-Nitroguanosine 3',5'-cyclic monophosphate (8-nitro-cGMP), formed nitric oxide (NO)-dependently, is a physiological second messenger, yet little is known about its role in the pathophysiology of vascular diseases. To study the pharmacological activity of 8-nitro-cGMP in diabetic mice, we compare...

journal_title：British journal of pharmacology

authors： Tokutomi Y,Kataoka K,Yamamoto E,Nakamura T,Fukuda M,Nako H,Toyama K,Dong YF,Ahmed KA,Sawa T,Akaike T,Kim-Mitsuyama S

更新日期：2011-04-01 00:00:00

abstract：:Adenosine produced a concentration-related enhancement of antigen-induced 5-hydroxytryptamine (5-HT) release from rat serosal mast cells. This potentiation was maximal following the simultaneous addition of adenosine with antigen. Enhancement of 5-HT release was accompanied by potentiation of the adenosine 3':5'-cycli...

journal_title：British journal of pharmacology

authors： Church MK,Hughes PJ,Vardey CJ

更新日期：1986-01-01 00:00:00

abstract：:1. The pharmacological characteristics of alpha 1-adrenoceptor binding sites in rat pineal gland membranes, detected by use of a selective alpha 1-adrenoceptor antagonist ([125I]-iodo-2-[beta-(4-hydroxyphenyl) ethylaminomethyl]tetralone, [125I]-HEAT), were investigated with the alkylating agent, chloroethylclonidine (...

journal_title：British journal of pharmacology

authors： Sugden D,Anwar N,Klein DC

更新日期：1996-07-01 00:00:00

abstract：:1. Caerulein displayed a potent stimulant action on pancreatic secretion in the dog. Threshold doses were 1-5 ng/kg by rapid intravenous injection, 0.25-1 ng/kg per min by intravenous infusion and 50-100 ng/kg by subcutaneous injection. There was a conspicuous increase not only in the volume flow of pancreatic juice b...

journal_title：British journal of pharmacology

authors： Bertaccini G,De Caro G,Endean R,Erspamer V,Impicciatore M

更新日期：1969-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Acute activation of κ opioid (KOP) receptors results in anticocaine-like effects, but adverse effects, such as dysphoria, aversion, sedation and depression, limit their clinical development. Salvinorin A, isolated from the plant Salvia divinorum, and its semi-synthetic analogues have been shown t...

journal_title：British journal of pharmacology

authors： Simonson B,Morani AS,Ewald AW,Walker L,Kumar N,Simpson D,Miller JH,Prisinzano TE,Kivell BM

更新日期：2015-01-01 00:00:00