Does occupational exposure to silica cause lung cancer?

Abstract:

:Silica is not generally considered to be a carcinogen, however, occupations characterized by high exposure to crystalline silica have excessive rates of lung cancer mortality. Respiratory cancer excesses have been reported from North America and from Europe for the following dusty trades in which exposure to silica is a common factor: iron and steel foundry workers, steel casting workers, sand blasters, metal molders, non-uranium miners, and ceramic workers. These findings have been reinforced by two reports from the Swedish Pneumoconiosis Register and the Ontario Ministry of Labor indicating that silicotics have statistically significant risks of lung cancer mortality. Animal studies suggest that silica can be an initiating carcinogen or can act as a cocarcinogen or promoter when combined with benzo(a)pyrene. We propose three candidate hypotheses and two pathways for silicocarcinogenesis.

journal_name

Am J Ind Med

authors

Goldsmith DF,Guidotti TL,Johnston DR

doi

10.1002/ajim.4700030408

subject

Has Abstract

pub_date

1982-01-01 00:00:00

pages

423-40

issue

4

eissn

0271-3586

issn

1097-0274

journal_volume

3

pub_type

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