In vitro suppression of K65R reverse transcriptase-mediated tenofovir- and adefovir-5'-diphosphate resistance conferred by the boranophosphonate derivatives.

abstract：:Human cytomegalovirus (HCMV) infection does not generally cause problems in the immunocompetent adult but can result in severe clinical disease in the fetus, neonate, and immunocompromised host. Ganciclovir (GCV), the agent currently used to treat most HCMV infections, has resulted in much therapeutic success; however...

journal_title：Antimicrobial agents and chemotherapy

authors： Rybak RJ,Hartline CB,Qiu YL,Zemlicka J,Harden E,Marshall G,Sommadossi JP,Kern ER

更新日期：2000-06-01 00:00:00

abstract：:We compared the in vitro activity of gemifloxacin, a new quinolone antibiotic, to the activities of levofloxacin, moxifloxacin, trovafloxacin, erythromycin, and doxycycline against 20 isolates of Chlamydia pneumoniae. Gemifloxacin was the most active quinolone tested, with a MIC at which 90% of the isolates are inhibi...

journal_title：Antimicrobial agents and chemotherapy

authors： Roblin PM,Reznik T,Kutlin A,Hammerschlag MR

更新日期：1999-11-01 00:00:00

abstract：:Nontyphoidal Salmonella enterica strains with a nonclassical quinolone resistance phenotype were isolated from patients returning from Thailand or Malaysia to Finland. A total of 10 isolates of seven serovars were studied in detail, all of which had reduced susceptibility (MIC > or = 0.125 microg/ml) to ciprofloxacin ...

journal_title：Antimicrobial agents and chemotherapy

authors： Gunell M,Webber MA,Kotilainen P,Lilly AJ,Caddick JM,Jalava J,Huovinen P,Siitonen A,Hakanen AJ,Piddock LJ

更新日期：2009-09-01 00:00:00

abstract：:According to the European AIDS Clinical Society, tenofovir disoproxil fumarate can be used in HIV-infected pregnant women if started prior to pregnancy, although no data are available on the pharmacokinetics of tenofovir (TFV) during pregnancy. The aim of this study was to describe TFV pharmacokinetics in HIV-infected...

journal_title：Antimicrobial agents and chemotherapy

authors： Benaboud S,Hirt D,Launay O,Pannier E,Firtion G,Rey E,Bouazza N,Foissac F,Chappuy H,Urien S,Tréluyer JM

更新日期：2012-02-01 00:00:00

abstract：:Infection with multiple ganciclovir-resistant human cytomegalovirus mutants, containing different substitutions and deletions in the UL97 gene, was found in a patient with severe combined immunodeficiency (SCID) within 3 weeks of ganciclovir therapy. A novel 11-codon deletion at positions 590 to 600 was identified. Th...

journal_title：Antimicrobial agents and chemotherapy

authors： Wolf DG,Yaniv I,Ashkenazi S,Honigman A

更新日期：2001-02-01 00:00:00

abstract：:A multicenter susceptibility surveillance (the S.A.U.C.E. project) including 2,721 Streptococcus pneumoniae, 3,174 Streptococcus pyogenes, and 2,645 Haemophilus influenzae consecutive isolates was carried out in 25 hospitals all over Spain from November 2001 to October 2002 to evaluate the current epidemiology of resi...

journal_title：Antimicrobial agents and chemotherapy

authors： Pérez-Trallero E,García-de-la-Fuente C,García-Rey C,Baquero F,Aguilar L,Dal-Ré R,García-de-Lomas J,Spanish Surveillance Group for Respiratory Pathogens.

更新日期：2005-05-01 00:00:00

abstract：:The deduced amino acid sequence of Campylobacter jejuni Tet(O), cloned in Escherichia coli, has shown that it contains the five highly conserved sequences of the GTP-binding domain found in other GTPases. Asn-128 belongs to the G4 motif of such a domain and is involved in hydrogen bonding with the guanine ring of the ...

journal_title：Antimicrobial agents and chemotherapy

authors： Grewal J,Manavathu EK,Taylor DE

更新日期：1993-12-01 00:00:00

abstract：:Dientamoeba fragilis is a commonly encountered trichomonad which has been implicated as a cause of gastrointestinal disease in humans. Despite the frequency of reports recording infections with this parasite, little research has been undertaken in terms of antimicrobial susceptibility. The aim of this study was to eva...

journal_title：Antimicrobial agents and chemotherapy

authors： Nagata N,Marriott D,Harkness J,Ellis JT,Stark D

更新日期：2012-01-01 00:00:00

abstract：:The effect of the cephalosporin precursors and amino acids of the aspartic acid family on antibiotic production by Streptomyces clavuligerus was investigated DL-meso-Diaminopimelate and L-lysine each stimulated specific antibiotic production by 75%. A fourfold increase in specific production was obtained by simultaneo...

journal_title：Antimicrobial agents and chemotherapy

authors： Mendelovitz S,Aharonowitz Y

更新日期：1982-01-01 00:00:00

abstract：:The antimicrobial activities of calcium-deficient apatite loaded with different concentrations (25, 100, and 500 microg/mg) of vancomycin as a filling biomaterial were evaluated in a methicillin-resistant Staphylococcus aureus (MRSA) rabbit acute osteomyelitis model. Bacterial counts in bone, bone marrow, and joint fl...

journal_title：Antimicrobial agents and chemotherapy

authors： Amador G,Gautier H,Le Mabecque V,Miegeville AF,Potel G,Bouler JM,Weiss P,Caillon J,Jacqueline C

更新日期：2010-02-01 00:00:00

abstract：:Mycobacterium tuberculosis, the causative agent of human tuberculosis (TB), has surpassed HIV/AIDS as the leading cause of death from a single infectious agent. The increasing occurrence of drug-resistant strains has become a major challenge for health care systems and, in some cases, has rendered TB untreatable. Howe...

journal_title：Antimicrobial agents and chemotherapy

authors： Meikle V,Mossberg AK,Mitra A,Hakansson AP,Niederweis M

更新日期：2019-01-29 00:00:00

abstract：:The microdilution MICs of HMR 3647, erythromycin A, azithromycin, clarithromycin, roxithromycin, and pristinamycin against 50/90% of 249 Haemophilus influenzae and 50 Moraxella catarrhalis isolates were 2/4, 0.06/0.125; 8/16, 0.25/0.25; 2/4, 0.06/0.125; 16/16, 0.25/0.25; 32/>32, 1/2; and 2/4, 0.5/0.5 microg/ml. Azithr...

journal_title：Antimicrobial agents and chemotherapy

authors： Pankuch GA,Hoellman DB,Lin G,Bajaksouzian S,Jacobs MR,Appelbaum PC

更新日期：1998-11-01 00:00:00

abstract：:We have found a close correlation between viral stavudine (d4T) resistance and resistance to d4T-triphosphate at the human immunodeficiency virus type 1 reverse transcriptase (RT) level. RT from site-directed mutants with 69S-XX codon insertions and/or conventional zidovudine resistance mutations seems to be involved ...

journal_title：Antimicrobial agents and chemotherapy

authors： Lennerstrand J,Stammers DK,Larder BA

更新日期：2001-07-01 00:00:00

abstract：:Eighty adults in areas of Kenya where malaria is holoendemic received presumptive treatment with atovaquone-proguanil and were followed closely. The time to the first Plasmodium falciparum parasitemia was 32 days. This prolonged prophylaxis period has implications for study design when used in malaria intervention tri...

journal_title：Antimicrobial agents and chemotherapy

authors： Polhemus ME,Remich S,Ogutu B,Waitumbi J,Lievens M,Ballou WR,Heppner DG Jr

更新日期：2008-04-01 00:00:00

abstract：:Several classes of antibiotics exert antimalarial activity. The mechanisms of action of antibiotics against malaria parasites have been unclear, and prior studies have led to conflicting results, in part because they studied antibiotics at suprapharmacological concentrations. We examined the antimalarial effects of az...

journal_title：Antimicrobial agents and chemotherapy

authors： Dahl EL,Rosenthal PJ

更新日期：2007-10-01 00:00:00

abstract：:The efficacy of atovaquone alone or combined with pyrimethamine, sulfadiazine, clarithromycin, and minocycline was examined in vitro and in a murine model of acute toxoplasmosis. In vitro studies were performed with MRC5 fibroblast tissue cultures, with quantification of Toxoplasma growth by an enzyme-linked immunosor...

journal_title：Antimicrobial agents and chemotherapy

authors： Romand S,Pudney M,Derouin F

更新日期：1993-11-01 00:00:00

abstract：:The in vitro activities of ceftaroline and comparators, using broth microdilution, were determined against 1,066 Staphylococcus aureus isolates from hospitalized patients. Seventeen medical centers from Latin American countries contributed isolates. Methicillin-resistant S. aureus (MRSA) percentages ranged from 46% (B...

journal_title：Antimicrobial agents and chemotherapy

authors： Biedenbach DJ,Hoban DJ,Reiszner E,Lahiri SD,Alm RA,Sahm DF,Bouchillon SK,Ambler JE

更新日期：2015-12-01 00:00:00

abstract：:Hydroxamate-based chelators of iron are potent inhibitors of in vitro growth of Plasmodium falciparum. Two types of such chelators, the natural desferrioxamine and the synthetic reversed siderophore RSFileum2, are prototypes of antimalarial agents whose action spectra differ in the speed of action, stage dependence, a...

journal_title：Antimicrobial agents and chemotherapy

authors： Golenser J,Tsafack A,Amichai Y,Libman J,Shanzer A,Cabantchik ZI

更新日期：1995-01-01 00:00:00

abstract：:Initial studies indicate that rifampin may be useful for the treatment of Staphylococcus aureus infections. Because bacterial resistance to rifampin may develop rapidly, its widespread use could result in the emergence of a resistant flora. This study evaluates the effectiveness of rifampin in reducing the nasal carri...

journal_title：Antimicrobial agents and chemotherapy

authors： Sande MA,Mandell GL

更新日期：1975-03-01 00:00:00

abstract：:Ribavirin was inactive against the rotavirus of murine gastroenteritis; this may be due to the presence of guanosine inhibitors in the gut. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Schoub BD,Prozesky OW

更新日期：1977-10-01 00:00:00

abstract：:Plasmid-mediated resistance to polymyxins mediated by the MCR-1/2 determinants has been reported in Enterobacteriaceae worldwide. Using PCR-based and cloning strategies, a series of Moraxella spp. were screened for mcr-like genes. Moraxella spp. that are mainly animal pathogens but may also be human pathogens were ide...

journal_title：Antimicrobial agents and chemotherapy

authors： Kieffer N,Nordmann P,Poirel L

更新日期：2017-05-24 00:00:00

abstract：:Thirteen normal subjects were given 2, 3, or 4 g of ceftizoxime intravenously in a prospective single-blinded study. Serum and urine concentrations were measured for 48 h. The beta-phase serum half-life ranged from 1.4 to 1.7 h. Approximately 100% of the agent was recovered unchanged in the urine over 48 h. Six of 13 ...

journal_title：Antimicrobial agents and chemotherapy

authors： Peterson LR,Gerding DN,Van Etta LL,Eckfeldt JH,Larson TA

更新日期：1982-11-01 00:00:00

abstract：:The phosphodiesterase inhibitor tetrahydrophthalazinone NPD-008 was explored by phenotypic in vitro screening, target validation and ultrastructural approaches against Trypanosoma cruzi NPD-008 displayed activity against different forms and strains of T. cruzi (EC50 = 6.6 - 39.5 μM), increased cAMP levels of T. cruzi ...

journal_title：Antimicrobial agents and chemotherapy

authors： de Araújo JS,Peres RB,Bernardino da Silva P,Batista MM,Sterk GJ,Maes L,Caljon G,Leurs R,de Koning HP,Kalejaiye TD,Soeiro MNC

更新日期：2020-12-23 00:00:00

abstract：:Doravirine is a novel nonnucleoside reverse transcriptase inhibitor in development for use with other antiretroviral therapies to treat human immunodeficiency virus type 1 (HIV-1) infection. Doravirine metabolism predominantly occurs via cytochrome P450 3A with <10% of elimination occurring via the renal pathway. As s...

journal_title：Antimicrobial agents and chemotherapy

authors： Ankrom W,Yee KL,Sanchez RI,Adedoyin A,Fan L,Marbury T,Preston RA,Iwamoto M,Khalilieh SG

更新日期：2018-07-27 00:00:00

abstract：:Salmonella enterica serovar Typhi is an important pathogen exclusively for humans and causes typhoid or enteric fever. It has been shown that type IVB pili, encoded by the S. enterica serovar Typhi pil operon located in Salmonella pathogenicity island 7, are important in the pathogenic process. In this study, by using...

journal_title：Antimicrobial agents and chemotherapy

authors： Pan Q,Zhang XL,Wu HY,He PW,Wang F,Zhang MS,Hu JM,Xia B,Wu J

更新日期：2005-10-01 00:00:00

abstract：:Mycobacterium abscessus is intrinsically resistant to many antimycobacterial antibiotics, which presents serious problems in therapy. Here, we describe the development of a novel phenotype-based microscopic and computerized imaging drug screening approach. A pilot screen of 568 compounds from two libraries identified ...

journal_title：Antimicrobial agents and chemotherapy

authors： Richter A,Strauch A,Chao J,Ko M,Av-Gay Y

更新日期：2018-08-27 00:00:00

abstract：:A multidrug-resistant (MDR) Pseudomonas fulva strain was isolated in 2006 from a urine sample. The isolate harbored the blaIMP-1 gene, which was located in a chromosomal Tn402-like class 3 integron as a gene cassette array of aacA31-fosE-blaIMP-1 Two mutations in gyrA and one mutation in parC were detected in quinolon...

journal_title：Antimicrobial agents and chemotherapy

authors： Yamamoto M,Matsumura Y,Gomi R,Matsuda T,Nakano S,Nagao M,Tanaka M,Ichiyama S

更新日期：2018-07-27 00:00:00

abstract：:Nonnucleoside reverse transcriptase (RT) inhibitors (NNRTIs) are important components of current combination therapies for human immunodeficiency virus type 1 (HIV-1) infection. In screening of chemical libraries, we found 6-azido-1-benzyl-3-(3,5-dimethylbenzyl)uracil (AzBBU) and 6-amino-1-benzyl-3-(3,5-dimethylbenzyl...

journal_title：Antimicrobial agents and chemotherapy

authors： Ordonez P,Hamasaki T,Isono Y,Sakakibara N,Ikejiri M,Maruyama T,Baba M

更新日期：2012-05-01 00:00:00

abstract：:Toxoplasma gondii enters host cells via an active, self-driven process to fulfill its need for intracellular replication and survival. Successful host cell invasion is governed by sequential release of secretory proteins from three specialized organelles, including the micronemes, which contribute adhesive proteins ne...

journal_title：Antimicrobial agents and chemotherapy

authors： Teo CF,Zhou XW,Bogyo M,Carruthers VB

更新日期：2007-02-01 00:00:00

abstract：:Therapeutic options for severe infections caused by strains of oxacillin-resistant Staphylococcus aureus (ORSA) and coagulase-negative staphylococci (ORSE) are very limited. With the increasing resistance of such strains to aminoglycosides, rifampin, and currently available quinolone agents, as well as the recent docu...

journal_title：Antimicrobial agents and chemotherapy

authors： Bayer AS,Li C,Ing M

更新日期：1998-07-01 00:00:00