Diphenylcyclopropenone: examination for potential contaminants, mechanisms of sensitization, and photochemical stability.

Abstract:

:Diphenylcyclopropenone (DPCP) has recently been reported to be a potent contact sensitizer for the treatment of alopecia areata. DPCP is nonmutagenic in the Ames assay. Studies on chemical purity, stability, and mechanisms of action are lacking. DPCP is synthesized by cyclization of alpha, alpha'-dibromodibenzylketone. The latter elicits a reaction in guinea pigs sensitized to DPCP. We examined a commercial sample of DPCP by gas chromatography--mass spectrometry for the presence of contaminants. The stability of dilute solutions of DPCP in ethanol and cyclohexane to fluorescent light, sunlight, and heat was followed by ultraviolet (UV) spectrometry. The isosbestic point and half-life for this reaction were determined. We found no original or intermediate reagents in our sample. DPCP was found to decompose, forming diphenylacetylene on exposure to both sunlight and fluorescent light in less than 2 weeks. Samples shielded from the light at -70 degrees C and at room temperature were stable over a 4-week period. The extent of decomposition was the same in both ethanol and cyclohexane. It is possible that DPCP may act as a prosensitizer with the actual sensitizer liberated by a photoactivated intermediate (stable, metastable, or unstable) or a combination of these.

journal_name

J Am Acad Dermatol

authors

Wilkerson MG,Henkin J,Wilkin JK

doi

10.1016/s0190-9622(84)80456-9

subject

Has Abstract

pub_date

1984-11-01 00:00:00

pages

802-7

issue

5 Pt 1

eissn

0190-9622

issn

1097-6787

pii

S0190-9622(84)80456-9

journal_volume

11

pub_type

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