Abstract:
:Octa-O-bis-(R,R)-Tartarate Ditellurane (SAS) is a new Te(IV) compound, comprised of two tellurium atoms, each liganded by four oxygen atoms from two carboxylates and two alkoxides of two tartaric acids. Unlike many other Te(IV) compounds, SAS was highly stable in aqueous solution. It interacted with thiols to form an unstable Te(SR)(4) product. The product of the interaction of SAS with cysteine was isolated and characterized by mass spectroscopy and elemental analysis. SAS selectively inactivated cysteine proteases, but it did not inactivate other families of proteolytic enzymes. It displayed selectivity towards the cysteine protease cathepsin B, a human enzyme of pharmaceutical interest, with a second order rate constant k(i)/K(i)=5900 M(-1) s(-1).
journal_name
ChemMedChemjournal_title
ChemMedChemauthors
Yosef S,Brodsky M,Sredni B,Albeck A,Albeck Mdoi
10.1002/cmdc.200700155subject
Has Abstractpub_date
2007-11-01 00:00:00pages
1601-6issue
11eissn
1860-7179issn
1860-7187journal_volume
2pub_type
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