Abstract:
:1. The influence of sodium and potassium on the accumulation of 5-hydroxytryptamine (5-HT) by rat blood platelets was investigated.2. An absolute dependence of 5-HT uptake on the sodium concentration in the medium was found.3. Removal of potassium reduced the uptake by about 60%. High concentrations of potassium inhibited sodium-dependent accumulation.4. The observations have been discussed in terms of a carrier-mediated transport process for 5-HT operating in the platelet membrane.
journal_name
Br J Pharmacoljournal_title
British journal of pharmacologyauthors
Sneddon JMdoi
10.1111/j.1476-5381.1969.tb08506.xsubject
Has Abstractpub_date
1969-11-01 00:00:00pages
680-8issue
3eissn
0007-1188issn
1476-5381journal_volume
37pub_type
杂志文章abstract:BACKGROUND AND PURPOSE:Kinins are pro-inflammatory peptides that are released during tissue injury, including that caused by inflammatory bowel disease. Herein, we assessed the role and underlying mechanisms through which the absence of kinin B(1) receptors exacerbates the development of dextran sulfate sodium (DSS)-i...
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