Involvement of nitric oxide in the inhibition of angiogenesis by interleukin-2.

abstract：:A hallmark of heart failure is mitochondrial dysfunction leading to a bioenergetics imbalance in the myocardium. Consequently, there is much interest in targeting mitochondrial abnormalities to attenuate the pathogenesis of heart failure. This review discusses (i) how electron microscopy (EM) techniques have been fund...

journal_title：British journal of pharmacology

authors： Daghistani HM,Rajab BS,Kitmitto A

更新日期：2019-11-01 00:00:00

abstract：:1. The effect of the nitro-derivative of aspirin, NCX4016, was assessed on ischaemic ventricular arrhythmias and myocardial infarct size in anaesthetized pigs in comparison to native aspirin. 2. Pigs were given aspirin (10 mg kg(-1); n=6), low dose NCX4016 (18.4 mg kg(-1); n=6) or high dose NCX4016 (60 mg kg(-1); n=7)...

journal_title：British journal of pharmacology

authors： Wainwright CL,Miller AM,Work LM,Del Soldato P

更新日期：2002-04-01 00:00:00

abstract：:The effects of several anticonvulsant drugs on sodium-dependent high affinity choline uptake (HACU) in mouse hippocampal synaptosomes was investigated. HACU was measured in vitro after in vivo administration of the drug to mice. HACU was inhibited by drugs which have in common the ability to facilitate gamma-aminobuty...

journal_title：British journal of pharmacology

authors： Miller JA,Richter JA

更新日期：1985-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Activation of cannabinoid receptors decreases emesis, inflammation, gastric acid secretion and intestinal motility. The ability to modulate intestinal permeability in inflammation may be important in therapy aimed at maintaining epithelial barrier integrity. The aim of the present study was to de...

journal_title：British journal of pharmacology

authors： Alhamoruni A,Wright KL,Larvin M,O'Sullivan SE

更新日期：2012-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Preclinical cardiovascular safety studies (CVS) have been compared between facilities with respect to their sensitivity to detect drug-induced QTc prolongation (ΔQTc). Little is known about the consistency of quantitative ΔQTc predictions that are relevant for translation to humans. EXPERIMENTAL...

journal_title：British journal of pharmacology

authors： Gotta V,Cools F,van Ammel K,Gallacher DJ,Visser SA,Sannajust F,Morissette P,Danhof M,van der Graaf PH

更新日期：2015-09-01 00:00:00

abstract：:1 Sera of rabbits immunized against a nocotinic receptor-rich fraction, obtained from the electric organ of Torpedo marmorata, were tested for their pharmacological activity on different in vitro preparations. 2 Sera containing antibodies against the nicotinic receptor blocked neuromuscular transmission in the phrenic...

journal_title：British journal of pharmacology

authors： Berti F,Clementi F,Conti-Tronconi B,Folco GC

更新日期：1976-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Rho kinase (ROCK) activation is involved in neuroinflammatory processes leading to progression of neurodegenerative diseases such as Parkinson's disease. Furthermore, ROCK plays a major role in angiogenesis. Neuroinflammation and angiogenesis are mechanisms involved in developing l-DOPA-induced d...

journal_title：British journal of pharmacology

authors： Lopez-Lopez A,Labandeira CM,Labandeira-Garcia JL,Muñoz A

更新日期：2020-12-01 00:00:00

abstract：:The mechanism of the long duration of action of salmeterol at beta(2)-adrenoceptors has long been a matter of debate, and is still unresolved. Szczuka and colleagues have both summarized the position to date and suggested a new mechanistic contender, receptor rebinding. Despite this, they still do not come to any clea...

journal_title：British journal of pharmacology

authors： Coleman RA

更新日期：2009-09-01 00:00:00

abstract：:1. Single smooth muscle cells were isolated from bovine trachealis by enzymic digestion. The properties of large conductance plasmalemmal K(+)-channels in these cells were studied by the patch-clamp recording technique. 2. Recordings were made from inside-out plasmalemmal patches when [K+] was symmetrically high (140 ...

journal_title：British journal of pharmacology

authors： Green KA,Foster RW,Small RC

更新日期：1991-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Certain 5-lipoxygenase (5-LO) inhibitors exhibit anti-carcinogenic activities against 5-LO overexpressing tumour types and cultured tumour cells. It has been proposed therefore that 5-LO products significantly contribute to tumour cell proliferation. To date, the relationship between the inhibito...

journal_title：British journal of pharmacology

authors： Fischer AS,Metzner J,Steinbrink SD,Ulrich S,Angioni C,Geisslinger G,Steinhilber D,Maier TJ

更新日期：2010-10-01 00:00:00

abstract：:1. Action potentials from guinea-pig single ventricular myocytes were interrupted by application of a 300 ms voltage clamp to -40 mV in order to evoke the Ca-activated tail current which is thought to be carried by Na:Ca exchange. Stimulation frequency was 1 Hz and temperature 36 degrees C. 2. The actions of ryanodine...

journal_title：British journal of pharmacology

authors： White E,Terrar DA

更新日期：1990-10-01 00:00:00

abstract：:1. Simultaneous computer modelling of control and guanfacine-masked [3H]-MK 912 saturation curves as well as guanfacine competition curves revealed that the drugs bound to two alpha 2-adrenoceptor subtypes in the rat cerebral cortex with very different selectivities. These alpha 2-adrenoceptor subtypes were designated...

journal_title：British journal of pharmacology

authors： Uhlén S,Xia Y,Chhajlani V,Felder CC,Wikberg JE

更新日期：1992-08-01 00:00:00

abstract：:1. This study tested the hypothesis that the systemic effects of burn include altered metabolic activity in the heart. Metabolic activity was studied by measuring alterations in cyclic nucleotide levels and protein concentrations in atrial and ventricular muscle in mice at 14 and 22 days after a 20% body surface area ...

journal_title：British journal of pharmacology

authors： Tomera JF,Martyn JA

更新日期：1990-10-01 00:00:00

abstract：:1. Inhibition of nitric oxide generation with Nw-nitro-L-arginine (nitroarginine) reduced vasodilator responses to bradykinin and acetylcholine and enhanced those to nitroprusside in the rat isolated perfused kidney, preconstricted with phenylephrine. 2. Inhibition of cyclo-oxygenase with indomethacin, decreased the v...

journal_title：British journal of pharmacology

authors： Fulton D,McGiff JC,Quilley J

更新日期：1992-11-01 00:00:00

abstract：:1 The effect of local elevation of leucocyte cyclic adenosine 3',5'-monophosphate (cyclic AMP) content on the continued migration of leucocytes to a site of acute inflammation was studied in the pleural cavity of rats. 2 Leucocyte cyclic AMP levels were elevated by injecting with the irritant into the pleural cavity d...

journal_title：British journal of pharmacology

authors： Deporter DA

更新日期：1977-06-01 00:00:00

abstract：:1. The effects of prolonged cold storage on the mechanical and membranal responses to stimulation of alpha- and beta-adrenoceptors by phenylephrine and isoprenaline, respectively, were studied on the guinea-pig taenia caecum.2. Cold storage invariably caused a decrease in the resting membrane potential, and this effec...

journal_title：British journal of pharmacology

authors： Fukuda H,Shibata S

更新日期：1972-11-01 00:00:00

abstract：:Anthracyclines can cause cumulative dose-related cardiotoxicity characterized by changes in Ca(2+) metabolism, including dysfunction of the sacroplasmic reticulum (SR) and decreased expression of Ca(2+)-handling proteins, such as the ryanodine receptor (RyR2). In this study, we examined the effect of dexrazoxane (ICRF...

journal_title：British journal of pharmacology

authors： Burke BE,Gambliel H,Olson RD,Bauer FK,Cusack BJ

更新日期：2000-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Proteinase activated receptor 2 (PAR2) is a GPCR associated with inflammation, metabolism and disease. Clues to understanding how to block PAR2 signalling associated with disease without inhibiting PAR2 activation in normal physiology could be provided by studies of biased signalling. EXPERIMENT...

journal_title：British journal of pharmacology

authors： Suen JY,Cotterell A,Lohman RJ,Lim J,Han A,Yau MK,Liu L,Cooper MA,Vesey DA,Fairlie DP

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Down's syndrome is a common genetic cause of intellectual disability, for which there are no drug therapies. Mechanistic studies in a model of Down's syndrome [Ts65Dn (TS) mice] demonstrated that impaired cognitive function was due to excessive neuronal inhibitory tone. These deficits were normal...

journal_title：British journal of pharmacology

authors： Colas D,Chuluun B,Warrier D,Blank M,Wetmore DZ,Buckmaster P,Garner CC,Heller HC

更新日期：2013-07-01 00:00:00

abstract：:1. Using a guinea-pig model of allergic asthma, in which the animals display early (0-5 h) and late phase (8-23 h after antigen challenge) bronchoconstrictor reactions, the function of prejunctional inhibitory M2 and postjunctional M3 receptors in isolated tracheal preparations have been investigated. In addition, car...

journal_title：British journal of pharmacology

authors： ten Berge RE,Santing RE,Hamstra JJ,Roffel AF,Zaagsma J

更新日期：1995-02-01 00:00:00

abstract：:1. The ratio of the content of vasopressin to that of oxytocin (V/O ratio) was estimated in the supraoptic nucleus (SON), paraventricular nucleus (PVN) and posterior pituitary gland (PIT) of guinea-pigs.2. Extracts were assayed for antidiuretic activity to estimate vasopressin and for milk-ejecting activity to estimat...

journal_title：British journal of pharmacology

authors： Bisset GW,Errington ML,Richards CD

更新日期：1973-06-01 00:00:00

abstract：:1 Citrated platelet-rich plasma was prepared from New Zealand white rabbits before, during and after administration of chlorpromazine (2 mg/kg) intramuscularly once daily for 3 to 4 weeks. 2 In these plasmas, the velocity of platelet aggregation by 5-hydroxytryptamine (5-HT) added at 1, 3 and 10 microM increased great...

journal_title：British journal of pharmacology

authors： Baldacci M,Baldacci M,Bergel TD,Born GV,Hickman M

更新日期：1980-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Sphingosine 1-phosphate (S1P), an important inflammatory mediator, has been shown to regulate COX-2 production and promote various cellular responses such as cell migration. Mevastatin, an inhibitor of 3-hydroxy-3-methylglutaryl-CoA reductase (HMG-CoA), effectively inhibits inflammatory responses...

journal_title：British journal of pharmacology

authors： Hsu CK,Lin CC,Hsiao LD,Yang CM

更新日期：2015-11-01 00:00:00

abstract：:1. The effects of intradermally injected prostaglandins (PGs) E(1), E(2), F(1alpha) and F(2alpha) have been examined in the rat and in man.2. PGE(1) and PGE(2) caused an increase in local vascular permeability in rat skin; their potency was comparable with that of other putative mediators of inflammation (histamine, b...

journal_title：British journal of pharmacology

authors： Crunkhorn P,Willis AL

更新日期：1971-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Avoiding danger and finding food are closely related behaviours that are essential for surviving in a natural environment. Growing evidence supports an important role of gut-brain peptides in modulating energy homeostasis and emotional-affective behaviour. For instance, postprandial release of pa...

journal_title：British journal of pharmacology

authors： Verma D,Hörmer B,Bellmann-Sickert K,Thieme V,Beck-Sickinger AG,Herzog H,Sperk G,Tasan RO

更新日期：2016-06-01 00:00:00

abstract：:1. Endotoxin shock is accompanied by an increase in peripheral vascular permeability. It has been postulated that most biological activities of LPS are derived from lipid A moiety. Here we examined the effect of lipid A analogue ONO-4007 in increasing vascular permeability and the possible mediators in mouse skin by a...

journal_title：British journal of pharmacology

authors： Ishida H,Fujii E,Irie K,Yoshioka T,Muraki T,Ogawa R

更新日期：2000-07-01 00:00:00

abstract：:1. The action of substance P (SP) on the release of gamma-aminobutyric acid (GABA) and acetylcholine (ACh) and on contraction were studied in strips of the guinea-pig urinary bladder. Substance P induced a dose-dependent contraction of strips of guinea-pig urinary bladder (EC50 = 1.2 x 10(-9) M). This contraction was ...

journal_title：British journal of pharmacology

authors： Shirakawa J,Nakanishi T,Taniyama K,Kamidono S,Tanaka C

更新日期：1989-10-01 00:00:00

abstract：:1. The effect of adenosine triphosphate (ATP) and its stable analogues, alpha, beta-methylene-ATP and beta, gamma-methylene-ATP, on the efferent function of capsaicin-sensitive non-adrenergic, non-cholinergic (NANC) nerves was tested in guinea-pig isolated atria. 2. Transmural nerve stimulation of atria isolated from ...

journal_title：British journal of pharmacology

authors： Rubino A,Amerini S,Ledda F,Mantelli L

更新日期：1992-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Prefrontal dopamine release by the combined activation of 5-HT1A and sigma-1 (σ1 ) receptors is enhanced by the GABAA receptor antagonist picrotoxin in mice. Here, we examined whether this neurochemical event was accompanied by behavioural changes. EXPERIMENTAL APPROACH:Male mice were treated wi...

journal_title：British journal of pharmacology

authors： Hasebe S,Ago Y,Watabe Y,Oka S,Hiramatsu N,Tanaka T,Umehara C,Hashimoto H,Takuma K,Matsuda T

更新日期：2017-02-01 00:00:00

abstract：:1 Embryonic sensory neurones of the chick grown in dissociated cell culture respond to application of low concentrations of gamma-aminobutyric acid (GABA) with a change in resting membrane resistance (R(in)) and/or a change in action potential duration (APD) (Dunlap & Fischbach, 1978; Choi & Fischbach, 1981). Intracel...

journal_title：British journal of pharmacology

authors： Dunlap K

更新日期：1981-11-01 00:00:00