Three-dimensional electron microscopy techniques for unravelling mitochondrial dysfunction in heart failure and identification of new pharmacological targets.

abstract：:1 Twenty-two compounds classified as antidepressants, metabolites of antidepressants or putative antidepressants were assayed for their ability to antagonize the binding of (-)-[3H]-quinuclidinyl benzilate to muscarinic receptors in homogenates of human caudate nucleus. 2 Sixteen of these compounds were assayed for th...

journal_title：British journal of pharmacology

authors： El-Fakahany E,Richelson E

更新日期：1983-01-01 00:00:00

abstract：:1 Vasoactive intestinal polypeptide (VIP, 0.01- MicroM) produced dose-related relaxations of the mouse anococcygeus muscle. 2 Following incubation with indomethacin (2.8 microM 1 h) adenosine 5'-triphosphate (ATP, 0.5-10 mM) produced dose-related relaxations of the mouse anococcygeus. 3 Haemolysed blood reduced inhibi...

journal_title：British journal of pharmacology

authors： Gibson A,Tucker JF

更新日期：1982-09-01 00:00:00

abstract：:1. Whole-cell patch-clamp recordings were made from smooth muscle cells isolated from the longitudinal muscle layer of guinea-pig ileum. Carbachol (acting at muscarinic receptors) or histamine (acting at H1 histamine receptors) suppressed Ca2+ channel current. The effect of either agonist had an initial transient comp...

journal_title：British journal of pharmacology

authors： Unno T,Beech DJ,Komori S,Ohashi H

更新日期：1998-10-01 00:00:00

abstract：:1. The effects of forskolin, prostaglandin E1 (PGE1), dibutyryl cyclic AMP (db cyclic AMP), dibutyryl cyclic GMP (db cyclic GMP) and 3-isobutyl-l-methyl-xanthine (IBMX) were investigated on the expression of tissue factor and thrombomodulin activities on the surface of human saphenous vein endothelial cells (HSVEC) in...

journal_title：British journal of pharmacology

authors： Archipoff G,Beretz A,Bartha K,Brisson C,de la Salle C,Froget-Léon C,Klein-Soyer C,Cazenave JP

更新日期：1993-05-01 00:00:00

abstract：:Eotaxin is a novel C-C chemokine with selective chemoattractant activity for eosinophils. We determined whether eotaxin could be produced by human airway smooth muscle (HASM) cells in culture and examined its regulation by interleukin-10 (IL-10) and the corticosteroid, dexamethasone. Stimulation of the cells with inte...

journal_title：British journal of pharmacology

authors： Chung KF,Patel HJ,Fadlon EJ,Rousell J,Haddad EB,Jose PJ,Mitchell J,Belvisi M

更新日期：1999-07-01 00:00:00

abstract：:1 Rats with unilateral electrolytic lesions involving both parts of the substantia nigra show dose-related, ipsilateral circling responses to apomorphine which are stable over time. 2 In non-tolerant rats, morphine (up to 10 mg/kg) does not elicit any circling behaviour but as tolerance develops to morphine, initially...

journal_title：British journal of pharmacology

authors： Halliwell JV,Kumar R

更新日期：1980-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Endocannabinoids play an important role in modulating spinal nociceptive signalling, crucial for the development of pain. The cannabinoid CB1 receptor and the TRPV1 cation channel are both activated by the endocannabinoid anandamide, a product of biosynthesis from the endogenous lipid precursor N...

journal_title：British journal of pharmacology

authors： Nerandzic V,Mrozkova P,Adamek P,Spicarova D,Nagy I,Palecek J

更新日期：2018-06-01 00:00:00

abstract：:1. In circular smooth muscle of the guinea-pig gastric fundus, transmural nerve stimulation evoked a cholinergic excitatory junction potential (e.j.p.), and blockade of the e.j.p. by atropine revealed a non-adrenergic non-cholinergic (NANC) inhibitory junction potential (i.j.p.). 2. The amplitude of the e.j.p. was inc...

journal_title：British journal of pharmacology

authors： Ohno N,Xue L,Yamamoto Y,Suzuki H

更新日期：1996-03-01 00:00:00

abstract：:1. Diabetic modifications of nicotinic receptor-operated noncontractile Ca2- mobilization observed in the presence of anticholinesterase were investigated by measuring Ca(2+)-aequorin luminescence in diaphragm muscles of mice with diabetes induced by injections of streptozotocin (150 mg kg-1, bolus i.v.) and alloxan (...

journal_title：British journal of pharmacology

authors： Kimura I,Tsuneki H,Dezaki K,Kimura M

更新日期：1995-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Animal models of drug-seeking suggest that exposure to cues associated with self-administered drugs and drug primes might precipitate relapse via activation of central dopaminergic substrates. EXPERIMENTAL APPROACH:The effects of priming injections of dopamine and 5-HT agonists on drug-seeking a...

journal_title：British journal of pharmacology

authors： Schenk S,Gittings D,Colussi-Mas J

更新日期：2011-04-01 00:00:00

abstract：:We investigated the ability of the cannabinoid agonists CP55,940 (CB(1)/CB(2)) and anandamide (endogenous cannabinoid) to modulate electrical field stimulation (EFS)-induced acetylcholine (ACh) release from parasympathetic nerve terminals innervating guinea-pig trachea. We assessed whether modulation of transmitter re...

journal_title：British journal of pharmacology

authors： Spicuzza L,Haddad EB,Birrell M,Ling A,Clarke D,Venkatesan P,Barnes PJ,Belvisi MG

更新日期：2000-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Strontium ranelate reduces fracture risk in postmenopausal women with osteoporosis. Evidence from non-clinical studies and analyses of bone markers in phase III trials indicate that this is due to an increase in osteoblast formation and a decrease of osteoclastic resorption. The aim of this work ...

journal_title：British journal of pharmacology

authors： Brennan TC,Rybchyn MS,Green W,Atwa S,Conigrave AD,Mason RS

更新日期：2009-08-01 00:00:00

abstract：:1. The pharmacokinetics of cyclophosphamide were investigated in cancer patients. The data can be characterized by a two-compartment open model. The half life of the elimination phase of the drug ranged between 3 and 11 hours.2. Extensive tubular reabsorption of the drug resulted in the excretion of only a small perce...

journal_title：British journal of pharmacology

authors： Cohen JL,Jao JY,Jusko WJ

更新日期：1971-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Excessive production of nitric oxide (NO) by inducible NO synthase (iNOS) is thought to underlie the vascular dysfunction, systemic hypotension and organ failure that characterize endotoxic shock. Plasma levels of atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP) and C-type natriu...

journal_title：British journal of pharmacology

authors： Panayiotou CM,Baliga R,Stidwill R,Taylor V,Singer M,Hobbs AJ

更新日期：2010-08-01 00:00:00

abstract：:Robert F. Furchgott, pharmacologist and joint winner of the Nobel Prize for Medicine or Physiology (1998) died on the 12th of May 2009 aged 92. By unlocking the astonishingly diverse biological actions of nitric oxide, Furchgott leaves behind a rich legacy that has both revolutionized our understanding of human physio...

journal_title：British journal of pharmacology

authors： Martin W

更新日期：2009-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:7-Ketocholesterol, an oxysterol present in atherosclerotic lesions, induces smooth muscle cell (SMC) death, thereby destabilizing plaques. Statins protect patients from myocardial infarction, though they induce SMC apoptosis. We investigated whether statins and 7-ketocholesterol exerted additive ...

journal_title：British journal of pharmacology

authors： Martinet W,Schrijvers DM,Timmermans JP,Bult H

更新日期：2008-07-01 00:00:00

abstract：:1. This study analyses the receptors mediating the effects of bradykinin (BK) and analogues on neurogenic twitch contractions of the mouse isolated vas deferens evoked, in the presence of captopril (3 microM), by electrical field stimulation with trains of 4 rectangular 0.5 ms pulses of supramaximal strength, delivere...

journal_title：British journal of pharmacology

authors： Maas J,Rae GA,Huidobro-Toro JP,Calixto JB

更新日期：1995-04-01 00:00:00

abstract：:In recent years there has been a growing recognition of the influence of sex on brain structure and function, and in relation, on the susceptibility, prevalence and response to treatment of psychiatric disorders. Most theories and descriptions of the effects of sex on the brain are dominated by an analogy to the curre...

journal_title：British journal of pharmacology

authors： Joel D,Yankelevitch-Yahav R

更新日期：2014-10-01 00:00:00

abstract：:1. The effects of 8-bromoguanosine 3':5'-cyclic monophosphate (8-bromo-cyclic GMP) on phenylephrine-induced contractions and phosphatidylinositol (PI) hydrolysis were investigated in rat isolated caudal artery. The effects of the nucleotide were compared to those of felodipine, a dihydropyridine Ca2+ channel antagonis...

journal_title：British journal of pharmacology

authors： Lum Min SA,Tabrizchi R

更新日期：1995-09-01 00:00:00

abstract：:1. In the conscious rat, three tachykinin NK3 receptor antagonists, namely SR142801 ((S)-(N)-(1-(3-(1-benzoyl-3-(3,4-dichlorophenyl)piperidin-3-yl)pro pyl)-4-phenylpiperidin-4-yl)-N-methylacetamide), R820 (3-indolylcarbonyl-Hyp-Phg-N(Me)-Bzl) and R486 (H-Asp-Ser-Phe-Trp-beta-Ala-Leu-Met-NH2) were assessed against the ...

journal_title：British journal of pharmacology

authors： Cellier E,Barbot L,Regoli D,Couture R

更新日期：1997-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Allosteric modulators of ionotropic receptors and GPCRs might constitute valuable therapeutic tools for intervention in several diseases, including Parkinson's disease (PD). However, the possibility that some of these compounds could alter neurotransmission in health and disease has not been thor...

journal_title：British journal of pharmacology

authors： Zhang X,Feng ZJ,Chergui K

更新日期：2014-08-01 00:00:00

abstract：:We performed intracellular recordings from a rat corticostriatal slice preparation in order to compare the electrophysiological effects of the classical antiepileptic drug (AED) phenytoin (PHT) and the new AEDs lamotrigine (LTG) and gabapentin (GBP) on striatal neurons. PHT, LTG and GBP affected neither the resting me...

journal_title：British journal of pharmacology

authors： Calabresi P,Centonze D,Marfia GA,Pisani A,Bernardi G

更新日期：1999-02-01 00:00:00

abstract：:The extracellular matrix (ECM) is a salient feature of all solid tissues within the body. This complex, acellular entity is composed of hundreds of individual molecules whose assembly, architecture and biomechanical properties are critical to controlling the behaviour and phenotype of the different cell types residing...

journal_title：British journal of pharmacology

authors： Hastings JF,Skhinas JN,Fey D,Croucher DR,Cox TR

更新日期：2019-01-01 00:00:00

abstract：:5-Hydroxytryptamine (5-HT, 5-160 microgram kg-1) injected intravenously in pentobarbitone-anaesthetized, open-chest cats caused dose-dependent increases in pulmonary arterial and intratracheal pressures. There was also a marked systemic hypotension and bradycardia. The pulmonary effects were completely prevented by ke...

journal_title：British journal of pharmacology

authors： Ball HA,Parratt JR,Rodger IW

更新日期：1983-10-01 00:00:00

abstract：:1. We have investigated the effects of a standardised mixture of hydroxyethylrutosides (HR, Venoruton), a mixture of five of its main components (M) and each of the five components separately (7-mono-HR, 7,4'-di-HR, 7,3',4'-tri-HR, 5,7,3',4'-tetra-HR and 7,3'4'-tri HQ) upon the permeability of single perfused capillar...

journal_title：British journal of pharmacology

authors： Kendall S,Towart R,Michel CC

更新日期：1993-09-01 00:00:00

abstract：:Sodium transport has been measured in the isolated epithelium from colons of male Sprague-Dawley rats. Sodium transport in colons was induced by pretreating the animals with dexamethasone (6 mg kg-1) which caused the appearance of an amiloride-sensitive short circuit current within a few hours. Forskolin, a diterpene,...

journal_title：British journal of pharmacology

authors： Cuthbert AW,Spayne JA

更新日期：1983-07-01 00:00:00

abstract：:The processes underpinning post-developmental neurogenesis in the mammalian brain continue to be defined. Such processes involve the proliferation of neural stem cells and neural progenitor cells (NPCs), neuronal migration, differentiation and integration into a network of functional synapses within the brain. Both in...

journal_title：British journal of pharmacology

authors： Prenderville JA,Kelly ÁM,Downer EJ

更新日期：2015-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Lysophosphatidylinositol (LPI), a lipid signalling molecule, activates GPR55 and elevates intracellular Ca(2+). Here, we examine the actions of LPI in the rat resistance mesenteric artery and Ca(2+) responses in endothelial cells isolated from the artery. EXPERIMENTAL APPROACH:Vascular responses...

journal_title：British journal of pharmacology

authors： AlSuleimani YM,Hiley CR

更新日期：2015-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Toll-like receptor 4 (TLR4) plays a key role in the induction of inflammatory responses both in peripheral organs and the CNS. Curcumin exerts anti-inflammatory functions by interfering with LPS-induced dimerization of TLR4-myeloid differentiation protein-2 (MD-2) complex and suppressing pro-infl...

journal_title：British journal of pharmacology

authors： Zusso M,Mercanti G,Belluti F,Di Martino RMC,Pagetta A,Marinelli C,Brun P,Ragazzi E,Lo R,Stifani S,Giusti P,Moro S

更新日期：2017-05-01 00:00:00

abstract：:1. Previous studies suggested that nitric oxide (NO) may cause hyperpolarization and relaxation of canine colonic smooth muscle by both cGMP-dependent and cGMP-independent mechanisms. This hypothesis was tested using 1H-[1,2,4]oxadiazolo[4,3-a]quinoxaline-1-one (ODQ), a novel inhibitor of NO-stimulated guanylate cycla...

journal_title：British journal of pharmacology

authors： Franck H,Sweeney KM,Sanders KM,Shuttleworth CW

更新日期：1997-11-01 00:00:00