The effect of a selective 5-HT2 antagonist, ketanserin, on the pulmonary responses to Escherichia coli endotoxin.

abstract：:1. The modulation by alpha 2-adrenoceptors of the jaw-opening reflex (digastric electromyographic responses) elicited by orofacial electrical stimulation (OF-JOR) in pentobarbitone anaesthetized rats was investigated. 2. Increasing doses of clonidine (0.1-1000 micrograms kg-1, i.v.) reduced, in a dose-dependent manner...

journal_title：British journal of pharmacology

authors： García-Vallejo P,Barturen F,García-Sevilla JA

更新日期：1994-04-01 00:00:00

abstract：:We have demonstrated previously that infusion of angiotensin II (AngII) into hyperlipidemic mice augments atherosclerosis and results in the formation of abdominal aortic aneurysms (AAA). The purpose of this study was to determine the role of aldosterone in these AngII-induced vascular pathologies. Male apolipoprotein...

journal_title：British journal of pharmacology

authors： Cassis LA,Helton MJ,Howatt DA,King VL,Daugherty A

更新日期：2005-02-01 00:00:00

abstract：:1. Chronic administration of the benzodiazepine inverse agonist FG 7142 has previously been shown to induce seizure activity in mice. In the present study we have investigated the effects of acute and chronic treatment with FG 7142 in mice on the levels of acetylcholinesterase activity in cortex, hippocampus, midbrain...

journal_title：British journal of pharmacology

authors： Appleyard ME,Taylor SC,Little HJ

更新日期：1990-11-01 00:00:00

abstract：:RSD 921 is a novel, structurally unique, class I Na+ channel blocking drug under development as a local anaesthetic agent and possibly for the treatment of cardiac arrhythmias. The effects of RSD 921 on wild-type heart, skeletal muscle, neuronal and non-inactivating IFMQ3 mutant neuronal Na+ channels expressed in Xeno...

journal_title：British journal of pharmacology

authors： Pugsley MK,Goldin AL

更新日期：1999-05-01 00:00:00

abstract：:The Mediterranean diet (MedDiet) is one of the most widely described and evaluated dietary patterns in scientific literature. It is characterized by high intakes of vegetables, legumes, fruits, nuts, grains, fish, seafood, extra virgin olive oil, and a moderate intake of red wine. A large body of observational and exp...

journal_title：British journal of pharmacology

authors： Schwingshackl L,Morze J,Hoffmann G

更新日期：2020-03-01 00:00:00

abstract：:This study was performed to characterize the receptor subtypes involved in the endothelin stimulation of phospholipase D (PLD) in rat cortical astrocytes in primary culture. PLD activity was determined by measuring the formation of [32P]phosphatidylbutanol in [32P]orthophosphate prelabelled cells stimulated in the pre...

journal_title：British journal of pharmacology

authors： Servitja JM,Masgrau R,Sarri E,Picatoste F

更新日期：1998-08-01 00:00:00

abstract：:1. The polymorphonuclear neutrophils (PMN) activation and mobilization observed in acute cerebral infarction contribute to the brain tissue damage, but PMN could also be involved in postischemic functional injury of ischemied blood vessel. 2. This study was undertaken to investigate whether pharmacological neutropenia...

journal_title：British journal of pharmacology

authors： Pétrault O,Ouk T,Gautier S,Laprais M,Gelé P,Bastide M,Bordet R

更新日期：2005-04-01 00:00:00

abstract：:1. We have studied the effect of cannabinoid agonists (CP 55,940 and cannabinol) on intestinal motility in a model of intestinal inflammation (induced by oral croton oil in mice) and measured cannabinoid receptor expression, endocannabinoids (anandamide and 2-arachidonylglycerol) and anandamide amidohydrolase activity...

journal_title：British journal of pharmacology

authors： Izzo AA,Fezza F,Capasso R,Bisogno T,Pinto L,Iuvone T,Esposito G,Mascolo N,Di Marzo V,Capasso F

更新日期：2001-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The anti-cancer agent [Arg(6), D-Trp(7,9), N(me)Phe(8)]-substance P (6-11) (SP-G) modulates gastrin releasing peptide (GRP) and arginine vasopressin signalling in small cell lung cancer cells leading to growth arrest and apoptosis. We have shown that SP-G acts as a biased agonist at GRP receptors...

journal_title：British journal of pharmacology

authors： MacKinnon AC,Tufail-Hanif U,Wheatley M,Rossi AG,Haslett C,Seckl M,Sethi T

更新日期：2009-01-01 00:00:00

abstract：:1. Pregnancy is characterized by a decrease in systemic vascular resistance and a blunting of the angiotensin II (AII) pressor response. We studied the role of nitric oxide (NO) and prostanoids in these vascular changes of pregnancy in anaesthesized, ganglion blocked non-pregnant and pregnant rats. 2. Inhibition of NO...

journal_title：British journal of pharmacology

authors： Nathan L,Cuevas J,Chaudhuri G

更新日期：1995-03-01 00:00:00

abstract：:1. A series of opioid agonists, antagonists and their (+)-stereoisomers were tested for antiarrhythmic activity in the rat coronary artery occlusion model. 2. Naloxone (0.01-2 mg kg-1) significantly reduced the incidence and severity of cardiac arrhythmias, in accordance with previous published studies. 3. The non-opi...

journal_title：British journal of pharmacology

authors： Sarne Y,Flitstein A,Oppenheimer E

更新日期：1991-03-01 00:00:00

abstract：:Intraperitoneal and intracerebral injections of methyl beta-carboline-3-carboxylate (beta CCM) and intracerebral injections of RO 15-1788 were given to rats. The performance of the rats in the social interaction test was measured to determine if changes in social interaction induced by beta CCM were mediated in part b...

journal_title：British journal of pharmacology

authors： Hindley SW,Hobbs A,Paterson IA,Roberts MH

更新日期：1985-11-01 00:00:00

abstract：:1 Tissue was taken from guinea-pigs that had been injected with guanethidine (100 mg/kg, i.p.) 24 h before they were killed, and from paired control animals.2 Pretreatment with guanethidine caused a significant, substantial, and sometimes complete reduction of the nerve-mediated contractions of the vas deferens. There...

journal_title：British journal of pharmacology

authors： Furness JB

更新日期：1974-01-01 00:00:00

abstract：:1. The noradrenaline (NA) concentration in the "heart" (atria and right ventricle) of male rats was estimated at different periods following adrenal demedullation. For 1-3 weeks after the operation there was, in all rats, a reduction in NA content of the tissue, whereas, after somewhat longer intervals, the concentrat...

journal_title：British journal of pharmacology

authors： Borchard F,Vogt M

更新日期：1970-01-01 00:00:00

abstract：:1. The effects of NS 1619, the putative BKCa channel opener, were investigated on rat intact portal veins and on single smooth muscle cells enzymatically separated from the same tissue. 2. Under whole-cell patch clamp conditions with K-rich pipettes, exposure of single cells held at -10 mV to NS 1619 (10-33 microM) in...

journal_title：British journal of pharmacology

authors： Edwards G,Niederste-Hollenberg A,Schneider J,Noack T,Weston AH

更新日期：1994-12-01 00:00:00

abstract：:1. In order to define the electrophysiological mechanism(s) responsible for bradykinin (BK)-induced positive inotropic and chronotropic responses in isolated guinea-pig atria, effects of BK on the membrane currents were examined in isolated atrial cells using patch clamp techniques. 2. BK (0.1-1000 nM) increased the L...

journal_title：British journal of pharmacology

authors： Sakamoto N,Uemura H,Hara Y,Saito T,Masuda Y,Nakaya H

更新日期：1998-09-01 00:00:00

abstract：:Electrical field stimulation (EFS)-induced non-adrenergic non-cholinergic (NANC) relaxation responses in the rabbit vaginal wall were investigated. These NANC responses were partially inhibited with the nitric oxide synthase (NOS) inhibitors N(G)-nitro-L-arginine methyl ester (L-NAME; 500 microM), N(G)-nitro-L-arginin...

journal_title：British journal of pharmacology

authors： Ziessen T,Moncada S,Cellek S

更新日期：2002-01-01 00:00:00

abstract：:We have examined the effects of antagonists on the isometric contraction of the human saphenous vein produced by 5-hydroxytryptamine (5-HT). The 5-HT2-antagonist ketanserin (1 microM) had little effect on the lower part of the concentration-response curve to 5-HT, but markedly shifted the upper part of the curve. Yohi...

journal_title：British journal of pharmacology

authors： Docherty JR,Hyland L

更新日期：1986-09-01 00:00:00

abstract：:1. Ginsenosides, the active ingredients extracted from Panax ginseng, have been shown to promote nitric oxide (NO) release in bovine aortic endothelial cells. Since the endothelial cells and the perivascular nerves in penile corpus cavernosum contain NO synthase and an NO-like substance has been shown to be released f...

journal_title：British journal of pharmacology

authors： Chen X,Lee TJ

更新日期：1995-05-01 00:00:00

abstract：:(1) Rapid desensitization of ligand-gated ion channel receptors can alter the apparent activity of receptor modulators, as well as make detection of fast-channel activation difficult. Investigation of the antagonist pharmacology of ATP-sensitive homomeric P2X3 receptors is limited by agonist-evoked fast-desensitizatio...

journal_title：British journal of pharmacology

authors： Neelands TR,Burgard EC,Uchic ME,McDonald HA,Niforatos W,Faltynek CR,Lynch KJ,Jarvis MF

更新日期：2003-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Pancreatic cancer is a solid tumour that is often fatal. Hence, there is an urgent need to identify new drug targets for this disease. Highly proliferating cancer cells have an increased demand for nutrients and, therefore, need to up-regulate selective amino acid transporters. Here, we investiga...

journal_title：British journal of pharmacology

authors： Coothankandaswamy V,Cao S,Xu Y,Prasad PD,Singh PK,Reynolds CP,Yang S,Ogura J,Ganapathy V,Bhutia YD

更新日期：2016-12-01 00:00:00

abstract：:1. Measurements were made of the in vivo formation of inositol phosphates in the brains of C57/B1/601a mice treated acutely or chronically with lithium chloride (LiCl). 2. A single injection of LiCl (10 mEquiv kg-1, s.c.) 18 h before death increased the accumulation of [3H]-inositol phosphates ([3H]-Ins P's) in the br...

journal_title：British journal of pharmacology

authors： Whitworth P,Heal DJ,Kendall DA

更新日期：1990-09-01 00:00:00

abstract：:1. This study analyses the neural pathway involved in the modulation of gastric motor function by stress. 2. Systemic administration of low doses of endotoxin (40 microg kg(-1), i.v.) prevents the increase in gastric tone induced by 2-deoxy-D-glucose (200 mg kg(-1), i.v., 2-DG) in urethane-anaesthetized rats. 3. Funct...

journal_title：British journal of pharmacology

authors： Quintana E,García-Zaragozá E,Martínez-Cuesta MA,Calatayud S,Esplugues JV,Barrachina MD

更新日期：2001-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Nitric oxide (NO) is known to activate NO-sensitive guanylyl cyclase (NO-GC) and to elicit cGMP production. However, NO has also been proposed to induce cGMP-independent effects. It is accepted practice to use specific NO-GC inhibitors, such as ODQ or NS2028, to assess cGMP-dependent NO effects. ...

journal_title：British journal of pharmacology

authors： Lies B,Groneberg D,Gambaryan S,Friebe A

更新日期：2013-09-01 00:00:00

abstract：:1. Leukotriene B(4) (LTB(4)) stimulation of guinea-pig peritoneal eosinophils, induced a biphasic activation of the NADPH oxidase composed of a rapid (<3 min) phase mediated by non-adherent cells and a sustained (3 - 120 min) phase mediated by CD11b/CD18 adherent eosinophils. Studies were undertaken to compare the int...

journal_title：British journal of pharmacology

authors： Lynch OT,Giembycz MA,Barnes PJ,Lindsay MA

更新日期：2001-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Haem oxygenase-1 (HO-1) is induced by thiazolidinediones including rosiglitazone and exerts anti-inflammatory effects in various models. However, the molecular mechanisms underlying rosiglitazone-induced HO-1 expression remain largely unknown in human pulmonary alveolar epithelial cells (HPAEpiCs...

journal_title：British journal of pharmacology

authors： Cho RL,Yang CC,Tseng HC,Hsiao LD,Lin CC,Yang CM

更新日期：2018-10-01 00:00:00

abstract：:1 Noradrenaline (0.2 to 20 micrograms) and carbachol (0.1 to 1 microgram) injected into the preoptic/anterior hypothalamic area, evoked dose-dependent falls in core temperature at all sites tested, followed in most experiments by delayed increases that were not dose-related. Muscarine (0.1 to 10 microgram) produced ef...

journal_title：British journal of pharmacology

authors： Poole S,Stephenson JD

更新日期：1979-01-01 00:00:00

abstract：:1. [35S]t-butylbicyclophosphorothionate (TBPS) is a high affinity ligand for the picrotoxin site of GABA(A) receptors. Here we examined TBPS binding to the cloned receptors made of alpha 1, alpha 3 or alpha 6 in combination with beta 2 or beta 2 and gamma 2 subunits, in the presence of GABA and several allosteric liga...

journal_title：British journal of pharmacology

authors： Im WB,Pregenzer JF,Thomsen DR

更新日期：1994-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The thiourea derivative KB-R7943, originally developed as inhibitor of the plasma membrane Na(+)/Ca(2+) exchanger, has been shown to protect against myocardial ischemia-reperfusion injury. We have studied here its effects on mitochondrial Ca(2+) fluxes. EXPERIMENTAL APPROACH:[Ca(2+)] in cytosol,...

journal_title：British journal of pharmacology

authors： Santo-Domingo J,Vay L,Hernández-Sanmiguel E,Lobatón CD,Moreno A,Montero M,Alvarez J

更新日期：2007-07-01 00:00:00

abstract：:1. Transepithelial transport of a fluorescent derivative of octreotide (NBD-octreotide) was studied in freshly isolated, functionally intact renal proximal tubules from killifish (Fundulus heteroclitus). 2. Drug accumulation in the tubular lumen was visualized by means of confocal microscopy and was measured by image ...

journal_title：British journal of pharmacology

authors： Gutmann H,Miller DS,Droulle A,Drewe J,Fahr A,Fricker G

更新日期：2000-01-01 00:00:00