Abstract：
:1. Pregnancy is characterized by a decrease in systemic vascular resistance and a blunting of the angiotensin II (AII) pressor response. We studied the role of nitric oxide (NO) and prostanoids in these vascular changes of pregnancy in anaesthesized, ganglion blocked non-pregnant and pregnant rats. 2. Inhibition of NO synthesis with NG-nitro-L-arginine methyl ester (L-NAME) led to an increase in mean arterial pressure (MAP) which was of a significantly greater magnitude in pregnant rats in late gestation than in non-pregnant rats, or rats in mid-gestation. 3. The pressor response to varying doses of AII was attenuated during late pregnancy, and this attenuation was partially reversed by L-NAME. 4. The pressor response to varying doses of a vasoconstrictor, phenylephrine (PE), was also attenuated in late pregnancy. However, this attenuation was not reversed by L-NAME. 5. Inhibition of prostanoid biosynthesis with meclofenamate did not alter basal MAP, nor the pressor response to varying doses of AII or PE in pregnant and non-pregnant animals. 6. It is concluded that (a) increased NO synthesis occurs during late gestation and contributes both to the decrease in systemic vascular resistance, as well as the blunting of the pressor response to AII during pregnancy, and (b) prostaglandins are not important in the maintenance of basal vascular tone, or the blunting of the pressor response to AII during pregnancy.
journal_name
Br J Pharmacoljournal_title
British journal of pharmacologyauthors
Nathan L,Cuevas J,Chaudhuri Gdoi
10.1111/j.1476-5381.1995.tb13297.xsubject
Has Abstractpub_date
1995-03-01 00:00:00pages
955-60issue
5eissn
0007-1188issn
1476-5381journal_volume
114pub_type
杂志文章abstract：:1. The modification by Bay K 8644 of the vasodilator effects of nifedipine, diltiazem, nicorandil and nitroglycerin was investigated in the femoral arterial bed of anaesthetized dogs. 2. The right femoral artery was cannulated and its arterial bed was perfused with autologous blood at a constant pressure slightly high...
journal_title：British journal of pharmacology
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doi：10.1111/j.1476-5381.1988.tb11415.x
更新日期：1988-01-01 00:00:00
abstract：BACKGROUND AND PURPOSE:While the 5-HT and Rho-kinase (ROCK) pathways have been implicated in the development of pulmonary arterial hypertension (PAH), the nature of any interactions between them remain unclear. This study investigated a role for ROCK in 5-HT-regulated proliferative responses in lung fibroblasts in vivo...
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journal_title：British journal of pharmacology
pub_type： 杂志文章
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journal_title：British journal of pharmacology
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doi：10.1111/j.1476-5381.1995.tb16642.x
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abstract：BACKGROUND AND PURPOSE:Tolerance induced by morphine and other opiates remains a major unresolved problem in the clinical management of pain. There is now good evidence for the importance of MAPKs in morphine-induced antinociceptive tolerance. A member of the MAPK kinase kinase family, TGF-β activated kinase 1 (TAK1) i...
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doi：10.1038/sj.bjp.0700959
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doi：10.1038/sj.bjp.0705032
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更新日期：1991-07-01 00:00:00
abstract：:1 In cats anaesthetized with pentobarbitone, observations were made on respiration, spontaneous and evoked diaphragmatic electromyograms, blood pressure, heart rate, indirectly-induced contractions of the anterior tibialis muscle and nictitating membrane, and electrical excitability of the inspiratory centre in the me...
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pub_type： 杂志文章
doi：10.1038/sj.bjp.0707261
更新日期：2007-06-01 00:00:00
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doi：10.1111/j.1476-5381.1996.tb15307.x
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abstract：BACKGROUND AND PURPOSE:Transient receptor potential canonical 5 (TRPC5) channels are widely expressed, including in the CNS, where they potentiate fear responses. They also contribute to other non-selective cation channels that are stimulated by G-protein-coupled receptor agonists and lipid and redox factors. Steroids ...
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更新日期：2013-03-01 00:00:00
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journal_title：British journal of pharmacology
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doi：10.1111/j.1476-5381.1994.tb17074.x
更新日期：1994-11-01 00:00:00
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pub_type： 杂志文章
doi：10.1038/sj.bjp.0703552
更新日期：2000-09-01 00:00:00
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更新日期：1997-06-01 00:00:00
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journal_title：British journal of pharmacology
pub_type： 杂志文章
doi：10.1111/j.1476-5381.1980.tb10947.x
更新日期：1980-01-01 00:00:00
abstract：:In this issue of the BJP, Green et al. suggest that animal data could not be used to predict the adverse effects of 3,4-methylenedioxymethamphetamine (MDMA) in humans and that MDMA did not produce 5-HT neurotoxicity in the human brain. This proposal was, however, not accompanied by a review of the empirical evidence i...
journal_title：British journal of pharmacology
pub_type： 评论,杂志文章
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更新日期：2012-07-01 00:00:00
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pub_type： 杂志文章
doi：10.1038/sj.bjp.0703687
更新日期：2000-12-01 00:00:00
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pub_type： 杂志文章
doi：10.1038/sj.bjp.0703270
更新日期：2000-04-01 00:00:00
abstract：:Cartilage destruction is a key characteristic of arthritic disease, a process now widely established to be mediated by metzincins such as MMPs. Despite showing promise in preclinical trials during the 1990s, MMP inhibitors for the blockade of extracellular matrix turnover in the treatment of cancer and arthritis faile...
journal_title：British journal of pharmacology
pub_type： 杂志文章,评审
doi：10.1111/bph.14173
更新日期：2019-01-01 00:00:00
