Abstract：
:1. Skins of the lizard Anolis carolinensis darken in vitro in response to melanophore stimulating hormone (MSH), a peptide hormone, as well as to catecholamines. These hormones darken Anolis skins by dispersing the sub-cellular organelle, the melanosome, out into the dendritic processes of the dermal melanophores.2. Dibutyryl cyclic AMP and methylxanthines also darken skins. In addition, methylxanthines are synergistic with both catecholamines and MSH in causing skin darkening. These data suggest that the dispersion of melanosomes within melanophores in response to both MSH and catecholamines is mediated by cyclic AMP.3. alpha-Adrenoceptor blocking agents inhibit MSH-induced darkening but potentiate catecholamine-induced darkening. beta-Adrenoceptor blocking agents, in contrast, inhibit catecholamine-induced darkening but have no effect on MSH-induced darkening. This selective blockade of one receptor while the functional integrity of the other receptor is maintained suggests that MSH and catecholamines increase cyclic AMP levels through different receptors.4. Catecholamines exert their action through beta-adrenoceptors; MSH darkens skins through what appears to be a component of the alpha-adrenoceptor. beta-Adrenoceptor stimulation may stimulate adenyl cyclase to increase cyclic AMP levels whereas MSH may inhibit cyclic AMP phosphodiesterase thereby preventing cyclic AMP breakdown.
journal_name
Br J Pharmacoljournal_title
British journal of pharmacologyauthors
Goldman JM,Hadley MEdoi
10.1111/j.1476-5381.1970.tb09565.xsubject
Has Abstractpub_date
1970-05-01 00:00:00pages
160-6issue
1eissn
0007-1188issn
1476-5381journal_volume
39pub_type
杂志文章abstract：:1. Acute SR 58611A (0.25 mg kg-1), was effective in reducing the blood glucose response to a glucose tolerance test (GTT) in normal lean (control) and spontaneously obese/diabetic CBA/Ca mice and to be equipotent to 1.25 mg kg-1 glibenclamide in lean mice. 2. Neither brown (BAT) nor white (WAT) adipose tissue lipogene...
journal_title：British journal of pharmacology
pub_type： 杂志文章
doi：10.1038/sj.bjp.0702946
更新日期：1999-12-01 00:00:00
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journal_title：British journal of pharmacology
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doi：10.1111/j.1476-5381.1990.tb14075.x
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abstract：:1. In order to explore whether 5-HT4 receptor subtypes exist, we have characterized further the 5-HT4 receptor that mediates tachycardia in the piglet isolated right atrium. All experiments were carried out in the presence of propranolol (400 nM) and cocaine (6 microM). We used tryptamine derivatives, substituted benz...
journal_title：British journal of pharmacology
pub_type： 杂志文章
doi：10.1111/j.1476-5381.1993.tb13916.x
更新日期：1993-11-01 00:00:00
abstract：:1. Previous studies suggested that nitric oxide (NO) may cause hyperpolarization and relaxation of canine colonic smooth muscle by both cGMP-dependent and cGMP-independent mechanisms. This hypothesis was tested using 1H-[1,2,4]oxadiazolo[4,3-a]quinoxaline-1-one (ODQ), a novel inhibitor of NO-stimulated guanylate cycla...
journal_title：British journal of pharmacology
pub_type： 杂志文章
doi：10.1038/sj.bjp.0701487
更新日期：1997-11-01 00:00:00
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journal_title：British journal of pharmacology
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doi：10.1038/sj.bjp.0702731
更新日期：1999-08-01 00:00:00
abstract：:1. The pathological features of Gram-positive shock can be mimicked by the co-administration of two cell wall components of Staphylococcus aureus, namely lipoteichoic acid (LTA) and peptidoglycan (PepG). This is associated with the expression of the inducible isoform of nitric oxide synthase (iNOS) in various organs. ...
journal_title：British journal of pharmacology
pub_type： 杂志文章
doi：10.1111/j.1476-5381.1996.tb16053.x
更新日期：1996-12-01 00:00:00
abstract：:GPCRs can interact with each other to form homomers or heteromers. Homomers involve interactions with the same receptor type while heteromers involve interactions between two different GPCRs. These receptor-receptor interactions modulate not only the binding but also the signalling and trafficking properties of indivi...
journal_title：British journal of pharmacology
pub_type： 杂志文章,评审
doi：10.1111/bph.12798
更新日期：2014-09-01 00:00:00
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journal_title：British journal of pharmacology
pub_type： 杂志文章,评审
doi：10.1111/bph.14038
更新日期：2017-12-01 00:00:00
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doi：10.1111/bph.12880
更新日期：2014-12-01 00:00:00
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pub_type： 杂志文章
doi：10.1038/sj.bjp.0702607
更新日期：1999-06-01 00:00:00
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journal_title：British journal of pharmacology
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doi：10.1111/j.1476-5381.1993.tb13930.x
更新日期：1993-11-01 00:00:00
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pub_type： 杂志文章,评审
doi：10.1038/sj.bjp.0707658
更新日期：2008-03-01 00:00:00
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journal_title：British journal of pharmacology
pub_type： 杂志文章
doi：10.1111/j.1476-5381.1985.tb09462.x
更新日期：1985-09-01 00:00:00
abstract：:The past two decades have seen an immense increase in our appreciation of the vast range of signalling processes and supporting machinery that occur in cells. Pivotal to this is the notion of signal compartmentalization (compartmentation). Targeting by protein domains is critical in allowing signalling complexes to be...
journal_title：British journal of pharmacology
pub_type： 评论,杂志文章
doi：10.1111/j.1476-5381.2009.00359.x
更新日期：2009-09-01 00:00:00
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doi：10.1038/sj.bjp.0704813
更新日期：2002-08-01 00:00:00
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journal_title：British journal of pharmacology
pub_type： 杂志文章
doi：10.1111/j.1476-5381.1995.tb15930.x
更新日期：1995-12-01 00:00:00
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pub_type： 杂志文章,评审
doi：10.1111/bph.12231
更新日期：2013-07-01 00:00:00
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更新日期：2011-07-01 00:00:00
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doi：10.1038/sj.bjp.0700956
更新日期：1997-02-01 00:00:00
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更新日期：2005-01-01 00:00:00
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doi：10.1038/sj.bjp.0705810
更新日期：2004-06-01 00:00:00
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journal_title：British journal of pharmacology
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doi：10.1111/j.1476-5381.1990.tb12085.x
更新日期：1990-09-01 00:00:00
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pub_type： 杂志文章
doi：10.1038/sj.bjp.0702889
更新日期：1999-11-01 00:00:00
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journal_title：British journal of pharmacology
pub_type： 杂志文章
doi：10.1111/j.1476-5381.1995.tb13257.x
更新日期：1995-01-01 00:00:00
abstract：:The endothelial 5-HT receptor mediating relaxation of pig pulmonary artery has been characterized using the selective 5-HT(2B) receptor agonist BW 723C86 and a variety of structurally diverse 5-HT receptor antagonists. If arterial rings with intact endothelium were precontracted with prostaglandin F(2alpha) (3 microM)...
journal_title：British journal of pharmacology
pub_type： 杂志文章
doi：10.1038/sj.bjp.0703341
更新日期：2000-06-01 00:00:00
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journal_title：British journal of pharmacology
pub_type： 杂志文章
doi：10.1111/j.1476-5381.2011.01391.x
更新日期：2011-09-01 00:00:00
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journal_title：British journal of pharmacology
pub_type： 杂志文章
doi：10.1038/sj.bjp.0701694
更新日期：1998-03-01 00:00:00
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journal_title：British journal of pharmacology
pub_type： 杂志文章
doi：10.1038/sj.bjp.0705703
更新日期：2004-03-01 00:00:00
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journal_title：British journal of pharmacology
pub_type： 杂志文章
doi：10.1111/j.1476-5381.1977.tb07720.x
更新日期：1977-04-01 00:00:00
abstract：:Melatonin deprival in young rats induces alterations in cerebral arteriolar wall similar to those observed during aging: atrophy and a decrease in distensibility. In this study, we examined the effects of melatonin treatment on cerebral arteriolar structure and distensibility and on the lower limit of cerebral blood f...
journal_title：British journal of pharmacology
pub_type： 杂志文章
doi：10.1038/sj.bjp.0705629
更新日期：2004-02-01 00:00:00
