Regulation of Wnt/β-catenin signalling by tankyrase-dependent poly(ADP-ribosyl)ation and scaffolding.

abstract：:1. Peroxynitrite, a potent cytotoxic oxidant formed by the reaction of nitric oxide with superoxide anion, and hydroxyl radical, formed in the iron-catalysed Fenton reaction, are important mediators of reperfusion injury. In in vitro studies, DNA single strand breakage, triggered by peroxynitrite or by hydroxyl radica...

journal_title：British journal of pharmacology

authors： Cuzzocrea S,Zingarelli B,Costantino G,Szabó A,Salzman AL,Caputi AP,Szabó C

更新日期：1997-07-01 00:00:00

abstract：:1. Inducible NO synthase (iNOS) expression and activity were measured in the mouse macrophage cell line J774 after exposure to bacterial lipopolysaccharide (LPS) with or without interferon-gamma (IFN-gamma). 2. Inhibition of NOS activity by concomitant N(G)-monomethyl-L-arginine (L-NMMA) treatment further increased iN...

journal_title：British journal of pharmacology

authors： Llovera M,Pearson JD,Moreno C,Riveros-Moreno V

更新日期：2001-01-01 00:00:00

abstract：:Gut inflammation occurring in patients with inflammatory bowel diseases (IBD) is associated with an excessive immune response that is directed against constituents of the normal bacterial flora and results in the production of large amounts of inflammatory cytokines. Anti-cytokine compounds, such as the neutralizing T...

journal_title：British journal of pharmacology

authors： Caprioli F,Caruso R,Sarra M,Pallone F,Monteleone G

更新日期：2012-02-01 00:00:00

abstract：:The monamine oxidase (MAO) inhibitors harmaline, tranylcypromine, deprenyl, clorgyline and iproniazid were injected intraperitoneally for five days to rabbits at doses that produced significant MAO inhibition. The first three inhibitors raised the concentrations of pyruvate and lactate in blood, decreased the activity...

journal_title：British journal of pharmacology

authors： Ali BH

更新日期：1985-12-01 00:00:00

abstract：:1. Measurements were made of the in vivo formation of inositol phosphates in the brains of C57/B1/601a mice treated acutely or chronically with lithium chloride (LiCl). 2. A single injection of LiCl (10 mEquiv kg-1, s.c.) 18 h before death increased the accumulation of [3H]-inositol phosphates ([3H]-Ins P's) in the br...

journal_title：British journal of pharmacology

authors： Whitworth P,Heal DJ,Kendall DA

更新日期：1990-09-01 00:00:00

abstract：:1. The efflux and influx of tryptophan across the synaptosomal plasma membrane has been studied under a variety of experimental conditions, in order to examine the mechanism by which depolarization enhances the efflux of tryptophan from superfused synaptosomes. 2. Efflux of [3H]-tryptophan from preloaded superfused sy...

journal_title：British journal of pharmacology

authors： Collard KJ,Wilkinson LS,Lewis DJ

更新日期：1988-02-01 00:00:00

abstract：:Chemotherapy-induced immune-suppression is a common, but potential detrimental, adverse reaction in patients undergoing treatment for cancer and strategies with capacity to boost the immune cell populations are needed. Physical exercise training is a potent regulator of immune cell viability and function and may serve...

journal_title：British journal of pharmacology

authors： Schauer T,Hojman P,Gehl J,Christensen JF

更新日期：2020-05-25 00:00:00

abstract：:1 Rat isolated perfused hearts with the right sympathetic nerves attached were loaded with [3H]-(-)-noradrenaline. The nerves were stimulated with up to 40 trains of 10 pulses every min at 1 Hz, and the evoked increases of [3H-]noradrenaline overflow into the perfusate, of right atrial tension development and ventricu...

journal_title：British journal of pharmacology

authors： Fuder H,Muscholl E,Spemann R

更新日期：1983-05-01 00:00:00

abstract：:1 Endothelin-1 (ET-1), an endothelium-derived vasoactive peptide, participates in the regulation of endothelial function through mechanisms that are not fully elucidated. This study examined the impact of ET-1 on oxidative stress, apoptosis and cell proliferation in human umbilical vein endothelial cells (HUVEC). HUVE...

journal_title：British journal of pharmacology

authors： Dong F,Zhang X,Wold LE,Ren Q,Zhang Z,Ren J

更新日期：2005-06-01 00:00:00

abstract：:1. The macroscopic currents induced in cultured rat melanotrophs by exogenous gamma-aminobutyric acid (GABA) were analysed using the patch clamp recording technique. 2. Using various concentrations of intra- and extracellular chloride it was demonstrated that the conductance activated by GABA was chloride selective. S...

journal_title：British journal of pharmacology

authors： Kehl SJ,Hughes D,McBurney RN

更新日期：1987-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Iridoid glycosides containing the double bond scaffold of cyclopentapyran are reversible and orthosteric agonists of glucagon-like peptide-1 (GLP-1) receptors and exert anti-nociceptive and neuroprotective actions. Morroniside, derived from the medicinal herb Cornus officinalis, is an atypical se...

journal_title：British journal of pharmacology

authors： Xu M,Wu HY,Liu H,Gong N,Wang YR,Wang YX

更新日期：2017-04-01 00:00:00

abstract：:1. alpha 1-Adrenoceptor subtypes in rabbit thoracic aorta have been examined in binding and functional experiments. 2. [3H]-prazosin bound to two distinct populations of alpha 1-adrenoceptors (pKD,high = 9.94, Rhigh = 79.2 fmol mg-1 protein; pKD,low = 8.59, Rlow = 215 fmol mg-1 protein). Pretreatment with chloroethylc...

journal_title：British journal of pharmacology

authors： Oshita M,Kigoshi S,Muramatsu I

更新日期：1993-04-01 00:00:00

abstract：:1. We examined the effects of eprosartan, an AT(1) receptor antagonist, on the progression of left ventricular (LV) dysfunction and remodelling in dogs with heart failure (HF) produced by intracoronary microembolizations (LV ejection fraction, EF 30 to 40%). 2. Dogs were randomized to 3 months of oral therapy with low...

journal_title：British journal of pharmacology

authors： Suzuki G,Mishima T,Tanhehco EJ,Sharov VG,Todor A,Rostogi S,Gupta RC,Chaudhry PA,Anagnostopoulos PV,Nass O,Goldstein S,Sabbah HN

更新日期：2003-01-01 00:00:00

abstract：:1 A 3 min intracoronary infusion of adenosine (50 mug/min) produced a significant decrease in coronary artery perfusion pressure, left ventricular systolic pressure and myocardial O2 consumption in the isolated supported heart preparation of the dog perfused at a constant coronary blood flow. Heart rate was controlled...

journal_title：British journal of pharmacology

authors： Gross GJ,Hardman HF,Warltier DC

更新日期：1976-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Partial agonists selective for α4β2 nicotinic ACh receptors have been developed for smoking cessation as they induce weak activation of native α4β2* receptors and inhibit effect of nicotine. However, it is unclear whether at brain functions there is an existence of receptor reserve that allows we...

journal_title：British journal of pharmacology

authors： Chen Y,Broad LM,Phillips KG,Zwart R

更新日期：2012-02-01 00:00:00

abstract：:1. The possible mechanisms of the antiproliferative and apoptotic effects of curcumin (diferuloylmethane), a polyphenol in the spice turmeric, on vascular smooth muscle cells were studied in rat aortic smooth muscle cell line (A7r5). 2. The proliferative response was determined from the uptake of [3H]-thymidine. Curcu...

journal_title：British journal of pharmacology

authors： Chen HW,Huang HC

更新日期：1998-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The effects of 4-O-methylhonokiol (MH), a constituent of Magnolia officinalis, were investigated on human prostate cancer cells and its mechanism of action elucidated. EXPERIMENTAL APPROACH:The anti-cancer effects of MH were examined in prostate cancer and normal cells. The effects were validate...

journal_title：British journal of pharmacology

authors： Lee NJ,Oh JH,Ban JO,Shim JH,Lee HP,Jung JK,Ahn BW,Yoon DY,Han SB,Ham YW,Hong JT

更新日期：2013-03-01 00:00:00

abstract：:1 Ca(2+)-activated Cl(-) currents (I(Cl(Ca))) evoked by K(+)-free pipette solutions containing 500 nM Ca(2+) were recorded in rabbit pulmonary artery smooth muscle cells. A voltage step protocol in which the cells were stepped to +70 mV and then to -80 mV produced outward and inward Cl(-) currents respectively that ex...

journal_title：British journal of pharmacology

authors： Piper AS,Greenwood IA

更新日期：2003-01-01 00:00:00

abstract：:1 The relative potencies of methotrimeprazine, (+)-methotrimeprazine, (+/-)-10-(3-dimethylamino-2-methylpropyl)-2-valeroyl phenothiazine hydrochloride (M & B 18,706) and (+)-M & B 18,706 in reducing the pressor action of noradrenaline in the spinal cat, reducing intercollicular decerebrate rigidity, and muscle spindle...

journal_title：British journal of pharmacology

authors： Maxwell DR,Sumpter EA

更新日期：1974-03-01 00:00:00

abstract：:1 A procedure involving two guinea-pig isolated hearts perfused in series is described for detecting in the recipient heart the release of a possible coronary vasodilator metabolite from the donor heart. 2 Adrenaline and isoprenaline stimulated the rate and force of contraction and produced a multiphasic coronary vasc...

journal_title：British journal of pharmacology

authors： Broadley KJ

更新日期：1976-09-01 00:00:00

abstract：:1. Anaesthetized, open-chest dogs were subjected to 60 min of left circumflex coronary artery occlusion followed by 90 min of reperfusion. Endothelium-dependent and -independent relaxant responses of the isolated coronary arterial rings were then investigated. 2. The endothelium-dependent, acetylcholine-induced relaxa...

journal_title：British journal of pharmacology

authors： Sobey CG,Dalipram RA,Dusting GJ,Woodman OL

更新日期：1992-03-01 00:00:00

abstract：:S-nitrosothiols have a number of potential clinical applications, among which their use as antithrombotic agents has been emphasized. This is largely because of their well-documented platelet inhibitory effects, which show a degree of platelet selectivity, although the mechanism of this remains undefined. Recent progr...

journal_title：British journal of pharmacology

authors： Gordge MP,Xiao F

更新日期：2010-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:A putative novel cannabinoid receptor mediates vasorelaxation to anandamide and abnormal-cannabidiol and is blocked by O-1918 and by high concentrations of rimonabant. This study investigates VSN16, a novel water-soluble agonist, as a vasorelaxant potentially acting at non-CB1, non-CB2 cannabinoi...

journal_title：British journal of pharmacology

authors： Hoi PM,Visintin C,Okuyama M,Gardiner SM,Kaup SS,Bennett T,Baker D,Selwood DL,Hiley CR

更新日期：2007-11-01 00:00:00

abstract：:1. The purpose of the present investigations was to determine the influence of increasing age on the pharmacokinetics and pharmacodynamics of midazolam in male BN/BiRij rats as an animal model of aging. 2. Midazolam was administered intravenously at a dose of 2.5 mg kg-1 and its pharmacokinetics were determined on the...

journal_title：British journal of pharmacology

authors： Hovinga S,Stijnen AM,Langemeijer MW,Mandema JW,van Bezooijen CF,Danhof M

更新日期：1992-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Quercetin lowers plasma glucose, normalizes glucose tolerance tests and preserves pancreatic β-cell integrity in diabetic rats. However, its mechanism of action has never been explored in insulin-secreting β-cells. Using the INS-1 β-cell line, the effects of quercetin were determined on glucose- ...

journal_title：British journal of pharmacology

authors： Youl E,Bardy G,Magous R,Cros G,Sejalon F,Virsolvy A,Richard S,Quignard JF,Gross R,Petit P,Bataille D,Oiry C

更新日期：2010-10-01 00:00:00

abstract：:1. The effects of various metabotropic glutamate receptor agonists on [3H]-cyclic AMP accumulation and phosphoinositide hydrolysis were investigated in guinea-pig cerebral cortical slices prelabelled with [3H]-adenine or [3H]-inositol. 2. 1-Aminocyclopentane-1S,3R-dicarboxylate (1S,3R-ACPD), L-2-amino-4-phosphonobutan...

journal_title：British journal of pharmacology

authors： Cartmell J,Kemp JA,Alexander SP,Shinozaki H,Kendall DA

更新日期：1994-01-01 00:00:00

abstract：:1. Mice pretreated intraperitoneally for 2 days with delta-9-tetrahydrocannabinol (delta-9-THC) at a dose of 20 mg kg-1 day-1 and then challenged intravenously with this drug, 24 h after the second pretreatment, showed a 6 fold tolerance to the hypothermic effect of delta-9-THC. This pretreatment also induced toleranc...

journal_title：British journal of pharmacology

authors： Pertwee RG,Stevenson LA,Griffin G

更新日期：1993-12-01 00:00:00

abstract：:1 The binding of [3H]-muscimol, a potent gamma-aminobutyric acid (GABA) receptor agonist, to crude membrane preparations of bovine retina was studied, using a filtration method to isolate membrane-bound ligand. 2 Specific binding was found to be saturable and occurred at two binding sites with affinity constants of 4....

journal_title：British journal of pharmacology

authors： Osborne NN

更新日期：1980-01-01 00:00:00

abstract：:1. Calcium entry via neuronal calcium channels is essential for the process of neurotransmission. We investigated the calcium channel subtypes involved in the operation of cardiac autonomic neurotransmission by examining the effects of selective calcium channel blockers on the inotropic responses to electrical field s...

journal_title：British journal of pharmacology

authors： Serone AP,Angus JA

更新日期：1999-06-01 00:00:00

abstract：:The abilities of prostaglandin E1 (PGE1), PGE2, PGD2 and PGF2 alpha to antagonize striatal dopamine function were assessed following bilateral and unilateral injections into the striata of the rat and guinea-pig. Three tests were used to assess the effects of the bilateral injections, ability to antagonize dyskinetic ...

journal_title：British journal of pharmacology

authors： Costall B,Holmes SW,Kelly ME,Naylor RJ

更新日期：1985-08-01 00:00:00