Abstract:
:1. In the anaesthetized dog bombesin had a potent antidiuretic effect, and sometimes arrested urine flow completely. Threshold doses, by i.v. infusion, were of the order of 0.5-1 (ng/kg)/minute. Antidiuresis was the result of a reduction in glomerular filtration rate provoked by a fall in intraglomerular hydrostatic pressure. This, in its turn, was due to afferent vasoconstriction.2. The spasmogenic effect of bombesin on the smooth muscle of the afferent arterioles was directly demonstrated by the radioactive microspheres technique and indirectly by the (85)Kr washout method and by [(3)H]-p-aminohippurate clearance. The vascular compartment most sensitive to bombesin was that of the outer cortical zone, especially in its external half.3. Filtration fraction decreased under the influence of bombesin, indicating that the effect of the polypeptide on postglomerular arterioles was, if present, only of minor importance.4. At high infusion rates (above 6 (ng/kg)/min), bombesin produced a decrease in [(3)H]-p-aminohippurate extraction. The effect of the polypeptide on fractional distal delivery of sodium varied with the dose: at moderate infusion rates it decreased, at high infusion rates it increased. The total glucose appearing in urine following a glucose load was sharply reduced by bombesin. However, the glomerular filtration rate/maximum tubular glucose transport ratio did not show any appreciable change.5. Afferent vasoconstriction produced by bombesin was accompanied by an intense activation of the renin-angiotensin system, as shown by a conspicuous increase in renin secretion, followed by increases in renin activity and angiotensin II concentration in arterial blood. When bombesin was infused into one renal artery only the infused kidney showed afferent vasoconstriction and increased renin secretion. The time-course of renin secretion produced by bombesin depended upon the rate of infusion of the polypeptide. At low rates an increased renin secretion was observed throughout the infusion period, at high rates two peaks of renin secretion could be seen, one at the beginning of the infusion, the other soon after the infusion had finished.6. The mechanism of action of bombesin is discussed and the interest of the polypeptide as a possible hormonal regulator of the circulation and function of the kidney is pointed out.
journal_name
Br J Pharmacoljournal_title
British journal of pharmacologyauthors
Erspamer V,Melchiorri P,Sopranzi Ndoi
10.1111/j.1476-5381.1973.tb08352.xsubject
Has Abstractpub_date
1973-07-01 00:00:00pages
438-55issue
3eissn
0007-1188issn
1476-5381journal_volume
48pub_type
杂志文章abstract::1. The NK1 tachykinin receptor agonists, septide, [Sar9,Met(O2)11]SP and [Pro9]SP produced locomotor hyperactivity (10-20 min) when injected intracerebroventricularly (i.c.v.) in the guinea-pig. The most potent in eliciting this hyperactivity was septide (from 0.63 to 5 micrograms), compared to [Sar9,Met(O2)11]SP, whi...
journal_title:British journal of pharmacology
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更新日期:1995-11-01 00:00:00
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journal_title:British journal of pharmacology
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doi:10.1111/j.1476-5381.1996.tb15392.x
更新日期:1996-05-01 00:00:00
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doi:10.1111/j.1476-5381.1992.tb12754.x
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更新日期:2004-05-01 00:00:00
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更新日期:1999-07-01 00:00:00
abstract::1 Physiologically, perisinusoidal hepatic stellate cells (HSC) are quiescent and store retinoids. During liver injury and in cell culture, HSC transform into proliferating myofibroblast-like cells that express alpha-smooth muscle actin (alpha-sma) and produce excessive amounts of extracellular matrix. During transform...
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更新日期:2003-06-01 00:00:00
abstract::1. The biotransformation of prostaglandin E(1) (PGE(1)) was studied in the isolated, perfused dog kidneys.2. An average 43% of PGE(1) was converted into the less polar metabolite I by a single passage through the kidney. As the re-circulation of the perfusate continued, PGE(1) was converted not only into metabolite I ...
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更新日期:1970-10-01 00:00:00
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更新日期:1974-01-01 00:00:00
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更新日期:1998-11-01 00:00:00
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更新日期:2008-05-01 00:00:00
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更新日期:2006-04-01 00:00:00
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journal_title:British journal of pharmacology
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更新日期:1987-09-01 00:00:00
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更新日期:2012-08-01 00:00:00
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更新日期:2010-10-01 00:00:00
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journal_title:British journal of pharmacology
pub_type: 杂志文章
doi:10.1111/j.1476-5381.1989.tb11847.x
更新日期:1989-03-01 00:00:00
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journal_title:British journal of pharmacology
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doi:10.1038/sj.bjp.0701461
更新日期:1997-11-01 00:00:00
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更新日期:2002-01-01 00:00:00
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journal_title:British journal of pharmacology
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更新日期:2017-06-01 00:00:00