Abstract：
AIM:To investigate effects of polymorphic variants of surfactant protein C gene (SFTPC) on the course of the disease in patients with chronic obstructive pulmonary disease (COPD). MATERIAL AND METHODS:Sixty COPD patients were examined with COPD of stage 0-IV. The following parameters were studied: smoking index (SI), bronchial patency, lung pathology by the findings of high resolution computed tomography, polymorphisms of SFTPC gene by the data of polymerase chain reaction (PCR) followed by mass-spectrometric detection. A trend was found to correlation between a polymorphic variant of A138C and COPD severity (p = 0.056). A CC genotype occurred more frequently in patients with COPD stages III and IV. A significant correlation exists between a polymorphic variant of A186G and the disease course severity (p = 0.23). Genotypes AA or AG are more typical for patients with COPD stage 0, I and II; GG genotype--stage III and IV. Genotype CC SFPTC A138C and genotype GG SFTPC A186G are significantly associated with pulmonary emphysema (p = 0.004 and p = 0.01, respectively). CONCLUSION:Polymorphic variants of SFTPC affect COPD course.
journal_name
Ter Arkhjournal_title
Terapevticheskii arkhivauthors
Tsvetkova OA,Veselovskaia MVsubject
Has Abstractpub_date
2007-01-01 00:00:00pages
65-9issue
9eissn
0040-3660issn
2309-5342journal_volume
79pub_type
杂志文章abstract：:Ceruloplasmin- and placebo-treated CHD patients were studied for severity of angina pectoris, changes in central hemodynamics, exercise tolerance. It is shown that ceruloplasmin promoted an increase in exercise tolerance, higher quality of life, arrest of the disease progress. Combined treatment of CHD incorporating c...
journal_title：Terapevticheskii arkhiv
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1995-01-01 00:00:00
abstract：:Data are presented on external respiration at rest and during exercise (bicycle ergometry) in 20 patients with chronic circulatory insufficiency due to a variety of heart diseases, as well as variation in the above in the course of treatment with digoxin and calcium antagonist corinfar. External respiration parameters...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：1986-01-01 00:00:00
abstract：:The authors review literature data on application of impulsed magnetic field (IMF) in clinical practice. IMF introduction in LE treatment is thought beneficial because IMF antiinflammatory, analgetic effects, positive action on microcirculation, immunological reactivity, the ability to upgrade the effect of combined t...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：1995-01-01 00:00:00
abstract：AIM:To study diagnostic significance of blood serum cancer antigens levels in patients who subsequently develop pulmonary cancer (PC) and gastrointestinal cancer (GIC). MATERIAL AND METHODS:ELISA was used to study expression of tumor antigens (CEA, NSE, CA19-9, CA242, AFP) in the blood serum of 27 PC and 31 GIC patien...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：2005-01-01 00:00:00
abstract：:As many as 195 patients with rheumatoid arthritis (RA) were examined for the clinical characteristics of the disease course depending on the presence or lack of antibodies to DNA or of antinuclear factor (ANF). Provided the patients' blood serum contained antibodies to DNA and ANF, RA was noted to run a graver course ...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：1991-01-01 00:00:00
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journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：2012-01-01 00:00:00
abstract：AIM:to determine the perspectives for the use of drugs with combined antiviral, anti - inflammatory and immunomodulatory activity on the basis of medical studies of existing antiviral drugs for the treatment of influenza and acute respiratory viral infections in Russia. MATERIALS AND METHODS:A brief review of the anti...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：10.26442/00403660.2019.11.000454
更新日期：2019-11-15 00:00:00
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journal_title：Terapevticheskii arkhiv
pub_type： 临床试验,杂志文章,多中心研究
doi：
更新日期：2000-01-01 00:00:00
abstract：:The paper discusses the problem of chronic heart failure (CHF) in left ventricular diastolic dysfunction - diastolic heart failure (DHF). It considers whether DHF is an independent phenotype or nothing more than a step in the development of systolic heart failure. The results of a number of studies evaluating the effi...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章,评审
doi：
更新日期：2009-01-01 00:00:00
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journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章,评审
doi：
更新日期：2013-01-01 00:00:00
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journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章,评审
doi：
更新日期：1994-01-01 00:00:00
abstract：AIM:The goal is to evaluate the effectiveness of pancreatic enzyme replacement therapy (PERT) using microencapsulated pancreatin preparations for the correction of nutritional status in patients with chronic pancreatitis (CP) and associated exocrine pancreatic insufficiency (EPI). MATERIALS AND METHODS:The study inclu...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：10.26442/00403660.2020.01.000488
更新日期：2020-01-15 00:00:00
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journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：1985-01-01 00:00:00
abstract：:Forty patients and 14 donors were examined. Twenty-two patients were diagnosed to have congestive cardiomyopathy (CCM), and 18 to have non-rheumatic myocarditis. The total number of T and B lymphocytes and lymphocyte subpopulations were measured by the method of surface markers (T mu and T gamma) and concurrently with...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：1984-01-01 00:00:00
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journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：2002-01-01 00:00:00
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journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：1992-01-01 00:00:00
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journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：2003-01-01 00:00:00
abstract：AIM:To analyze the influence of clinical and pharmacogenetic factors on the risk of resistance to original or generic clopidogrel and that of cardiovascular events (CVE) during 12 months of follow-up. SUBJECTS AND METHODS:Two hundred and fifty patients admitted to Moscow hospitals in October 2011 to September 2012 wer...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：2014-01-01 00:00:00
abstract：:Bilateral electrocoagulation of the central veins of the adrenals (ECVA) was performed in 13 patients with stable and malignant arterial hypertension (AH). The renin-dependent character of AH was supported by positive reaction of arterial pressure (AP) to the test dose of captopril (25 mg). The vasorenal origin of the...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：1990-01-01 00:00:00
abstract：AIM:The retrospective analysis of prevalence, peculiarities of duration of biliary calculosis without gall bladder cholesterosis, biliary calculosis with gall-bladder cholesterosis and xanthogranulematous cholecystitis among persons who underwent cholecystectomy using clinical, instrumental and morphological data. MATE...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：2008-01-01 00:00:00
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journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：1985-01-01 00:00:00
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journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：1988-01-01 00:00:00
abstract：:In three patients with multiple myeloma, stage IIIA, a complete remission lasting from 6 to 8 years was attained, in spite of the fact that not all of them received treatment. In the latter case the remission lasted from 5 to 6 years. One of the patients had diffuse Gk + BIk myeloma, one presented with multiple focal ...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：1985-01-01 00:00:00
abstract：:The authors appraise the efficacy of the treatment of severe aplastic anemia by splenectomy, antilymphocyte globulin and cyclophosphamide. A total of 120 patients were placed under observation. Of these, 103 patients had a severe disease pattern, one hundred and 112 patients with aplastic anemia including 96 with a se...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：1984-01-01 00:00:00
abstract：AIM:To reveal the effect of HBsAg on the serum lipid spectrum in alcoholics. MATERIALS AND METHODS:The serum lipid spectrum was studied in 30 alcoholics who were HBsAg carries, 50 alcoholics without HBsAg and 40 healthy individuals. RESULTS:Unlike alcoholic patients without HBsAg, those who were HBsAg carriers had hi...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：2002-01-01 00:00:00
abstract：:Hemocoagulation was examined in 477 diabetes mellitus patients. Whatever the disease type, severity, duration and the intensity of microvascular complications, diabetes mellitus was discovered to be marked by the development of chronic intravascular blood microcoagulation associated with primary hyperactivation of the...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：1991-01-01 00:00:00
abstract：:The atrial complex of ECG transbronchial leads (TB ECG) was in all cases recorded as two waves in line with right and left atrial contractions. Changes in atrial electrical activity reflect alterations in the lesser circulation. A new criterium of TB ECG atrial complex quantitation is suggested devised upon comparison...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：1994-01-01 00:00:00
abstract：AIM:To study the levels of inflammatory markers in acute coronary syndrome (ACS) and 6 months after its regression in patients with diabetes mellitus (DM) type 2; to evaluate effects of anxiodepressive disorders on inflammatory markers. MATERIAL AND METHODS:The levels of high-sensitive C-reactive protein (hsCRP), inte...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：2007-01-01 00:00:00
abstract：AIM:To study the effectiveness of a fixed combination of perindopril and amlodipine, with the subsequent addition of indapamide-retard in male patients with arterial hypertension (AH), obesity and severe sleep apnea (OSAS). MATERIALS AND METHODS:The study included 43 male patients in whom antihypertensive therapy titr...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：10.26442/00403660.2018.12.000005
更新日期：2018-12-30 00:00:00
abstract：AIM:To determine approaches of the exacerbations treatment of chronic pancreatitis (CP) with IBS (irritable bowel syndrome)-like syndrome. MATERIALS AND METHODS:312 patients with exacerbation of CP were observed and received standard therapy: antispasmodics, enzymes, proton pump inhibitors. 85 (27.2%) patients had no ...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：10.26442/00403660.2020.02.000518
更新日期：2020-04-27 00:00:00
