Abstract：
:A multicompartmental model is proposed to deal with the spread of the HIV epidemic. Stratification with respect to high- and low-risk groups is taken into account, introducing a "fuzzy" decomposition of the compartment of susceptibles. The infectivity period is staged using different levels of CD4 cell counts. Asymptotic behavior is studied, and some simulation results are reported in tabular and graphic forms.
journal_name
Math Bioscijournal_title
Mathematical biosciencesauthors
Rossi Cdoi
10.1016/0025-5564(91)90021-asubject
Has Abstractpub_date
1991-12-01 00:00:00pages
521-45issue
2eissn
0025-5564issn
1879-3134pii
0025-5564(91)90021-Ajournal_volume
107pub_type
杂志文章abstract：:Cyclic four-state models are frequently used in biology to represent a variety of molecular behaviors. A common experimental strategy to test such models is to follow the behavior of the real system after some of the rate constants are changed in a stepwise manner. We analyze the mathematical behavior of a simple exam...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/0025-5564(92)90086-c
更新日期：1992-11-01 00:00:00
abstract：:In this paper, we first propose a prey-predator model with prey-stage structure and diffusion. Then we discuss the following three problems: (1) stability of non-negative constant steady states for the reduced ODE system and the corresponding reaction diffusion system with homogeneous Neumann boundary conditions; (2) ...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/j.mbs.2007.08.008
更新日期：2008-04-01 00:00:00
abstract：:Calculations of the oxygen distribution in resting and contracting skeletal muscle are presented, based on a mathematical model and experimental data obtained on the hamster cremaster muscle [Klitzman et al., Microvasc. Res. 25:108-131 (1983)]. The model considers a slab of tissue penetrated by a regular square array ...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/0025-5564(86)90164-1
更新日期：1986-09-01 00:00:00
abstract：:In the present paper we have first introduced a measure of dynamical entropy of an ecosystem on the basis of the dynamical model of the system. The dynamical entropy which depends on the eigenvalues of the community matrix of the system leads to a consistent measure of complexity of the ecosystem to characterize the d...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/j.mbs.2013.07.016
更新日期：2013-10-01 00:00:00
abstract：:The transmission dynamics of a communicable disease in a subdivided population where the spread among groups follows the proportionate mixing model while the within-group transmission can correspond to preferred mixing, proportionate mixing among subgroups, or mixing between social and nonsocial subgroups, is analyzed...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/0025-5564(89)90061-8
更新日期：1989-10-01 00:00:00
abstract：:This article examines the functional and clinical impact of time delays that arise in human physiological systems, especially control systems. An overview of the mathematical and physiological contexts for considering time delays will be illustrated, from the system level to cell level, by examining models that incorp...
journal_title：Mathematical biosciences
pub_type： 杂志文章,评审
doi：10.1016/j.mbs.2011.08.006
更新日期：2011-12-01 00:00:00
abstract：:In automatic feedback control of intravenous drug infusions, convergence to the setpoint is an important objective. This paper examines the stability of pharmacokinetic-pharmacodynamic models of patient response regulated with proportional integral feedback. The model consists of three components: linear compartmental...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/s0025-5564(97)00076-x
更新日期：1997-12-01 00:00:00
abstract：:A mathematical model of the T-lymphocyte proliferation process (in vivo and in vitro) is presented. This model takes into account cell-cycle progression and the regulation by lymphokines (lymphocyte activating factor interleukin 1 and T-cell growth factor interleukin 2). Using data on the generalized picture of the sh...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/0025-5564(93)90071-h
更新日期：1993-06-01 00:00:00
abstract：:Frailty models are becoming increasingly popular in multivariate survival analysis. Shared frailty models in particular are often used despite their limitations. To overcome their disadvantages numerous correlated frailty models were established during the last decade. In the present study, we examine bivariate correl...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/j.mbs.2004.11.010
更新日期：2005-11-01 00:00:00
abstract：:Based on previously published experimental observations and mathematical models for Hes1, p53 and NF-kappaB gene expression, we improve these models through a distributed delay formulation of the time lag between transcription factor binding and mRNA production. This description of natural variability for delays intro...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/j.mbs.2006.08.010
更新日期：2007-02-01 00:00:00
abstract：:An inherent problem in studying the behavior of a metabolic pathway is the impossibility of developing a complete, detailed model that includes all the cellular processes that have an impact on the set of fluxes in such a pathway. Lacking this, one requires some means of modeling the interactions between a metabolic p...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/0025-5564(90)90049-5
更新日期：1990-06-01 00:00:00
abstract：:Therapeutic enhancement of humoral immune response to microbial attack is addressed as the stochastic optimal control of a dynamic system. Without therapy, the modeled immune response depends upon the initial concentration of pathogens in a simulated attack. Immune response can be augmented by agents that kill the pat...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/j.mbs.2004.06.004
更新日期：2004-10-01 00:00:00
abstract：:Metabolic flux analysis using carbon labeling experiments (CLEs) is an important tool in metabolic engineering where the intracellular fluxes have to be computed from the measured extracellular fluxes and the partially measured distribution of 13C labeling within the intracellular metabolite pools. The relation betwee...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/s0025-5564(02)00222-5
更新日期：2003-06-01 00:00:00
abstract：:The motions of many physical particles as well as living creatures are mediated by random influences or 'noise'. One might expect that over evolutionary time scales internal random processes found in living systems display characteristics that maximize fitness. Here we focus on animal random search strategies [G.M. Vi...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/j.mbs.2006.11.014
更新日期：2007-06-01 00:00:00
abstract：:This paper presents a novel epidemiological transmission model of a population affected by two different susceptible-infected-susceptible infectious diseases. For each disease, individuals fall into one of the two susceptibility conditions in which one of the diseases has the highest occurrence level. This model is un...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/j.mbs.2019.01.005
更新日期：2019-03-01 00:00:00
abstract：:A significant consideration in modeling systems with stages is to obtain models for the individual stages that have probability density functions (pdfs) of residence times that are close to those of the real system. Consequently, the theory of residence time distributions is important for modeling. Here I show first t...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/s0025-5564(02)00110-4
更新日期：2002-11-01 00:00:00
abstract：:In this work, we derive and analyze a 2n+1-dimensional deterministic differential equation modeling the transmission and treatment of HIV (Human Immunodeficiency Virus) disease. The model is extended to a stochastic differential equation by introducing noise in the transmission rate of the disease. A theoretical treat...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/j.mbs.2018.03.013
更新日期：2018-05-01 00:00:00
abstract：:In this paper, a mathematical modeling framework is presented which describes the growth, encapsulation, and transcapsular spread of solid tumors. The model is based on the physical forces and cellular interactions involved in tumorigenesis and is used to test and compare the active (foreign body hypothesis) and passi...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/s0025-5564(02)00118-9
更新日期：2002-11-01 00:00:00
abstract：:We apply to Michaelis-Menten kinetics an alternative approach to the study of Singularly Perturbed Differential Equations, that is based on the Renormalization Group (SPDERG). To this aim, we first rebuild the perturbation expansion for Michaelis-Menten kinetics, beyond the standard Quasi-Steady-State Approximation (s...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/j.mbs.2017.11.012
更新日期：2018-05-01 00:00:00
abstract：:Some viruses encode proteins that promote cell proliferation while others, such as the human immunodeficiency virus (HIV), encode proteins that prevent cell division. It has been hypothesized that the selective advantage determining which strategy evolves depends on the ability of the virus to induce a cellular enviro...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/s0025-5564(00)00020-1
更新日期：2000-07-01 00:00:00
abstract：:The methods of Laplace transform were used to solve a mathematical model developed for percutaneous drug absorption. This model includes application and removal of the vehicle from the skin. A system of two linear partial differential equations was solved for the application period. The concentration of the medicinal ...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/j.mbs.2005.07.002
更新日期：2005-10-01 00:00:00
abstract：:We consider a single-species model which is composed of several patches connected by linear migration rates and having logistic growth with a threshold. We show the existence of an aggregating mechanism that allows the survival of a species which is in danger of extinction due to its low population density. Numerical ...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/s0025-5564(00)00005-5
更新日期：2000-05-01 00:00:00
abstract：:We study the invasion of a top predator into a food chain in a chemostat. For each trophic level, a bioenergetic model is used in which maintenance and energy reserves are taken into account. Bifurcation analysis is performed on the set of nonlinear ordinary differential equations which describe the dynamic behaviour ...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/s0025-5564(98)10083-4
更新日期：1999-03-15 00:00:00
abstract：:The spread of the human immunodeficiency virus (HIV) depends prominently on the migration of people between different regions. An important consequence of this population mobility is that HIV control strategies that are optimal in a regional sense may not be optimal in a national sense. We formulate various mathematic...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/j.mbs.2008.03.003
更新日期：2008-06-01 00:00:00
abstract：:A stochastic model for hospital infection incorporating both direct transmission and indirect transmission via free-living bacteria in the environment is investigated. We examine the long term behavior of the model by calculating a stationary distribution and normal approximation of the distribution. The quasi-station...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/j.mbs.2012.10.002
更新日期：2013-01-01 00:00:00
abstract：:Weakly electric fish continuously emit a quasi-sinusoidal electric organ discharge (EOD) to probe their near environment (electrolocation). P-type tuberous receptors located on their skin respond to amplitude modulations of the EOD by varying their firing rate. These receptors, and the neuronal circuitry downstream fr...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/j.mbs.2003.08.012
更新日期：2004-03-01 00:00:00
abstract：:This paper describes an efficient method for tracing interactions between a radiation track and molecular targets in a cell or nucleus. The method is efficient because it ensures that a minimal subset of interactions in the track needs to be tested for each score. It is most useful for high-energy particles since the ...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/s0025-5564(98)10045-7
更新日期：1998-12-15 00:00:00
abstract：:A beam balance is analyzed as a model that describes Weber's law. The mathematical derivations of the torques on a beam balance produce a description that is strictly compatible with that law. The natural relationship of the beam balance model to Weber's law provides for an intuitive understanding of the relationship ...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/0025-5564(94)90083-3
更新日期：1994-07-01 00:00:00
abstract：:Many important results in stochastic epidemic modelling are based on the Reed-Frost model or on other similar models that are characterised by unrealistic temporal dynamics. Nevertheless, they can be extended to many other more realistic models thanks to an argument first provided by Ludwig [Final size distributions f...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/j.mbs.2008.08.009
更新日期：2008-11-01 00:00:00
abstract：:The problem addressed is that of finding the harvesting policy that will maximize the yield and maintain a given population in a steady state. It is assumed that the equations describing the evolution of the population and the yield are linear but that the equation describing reproduction is nonlinear (density depende...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/0025-5564(94)90039-6
更新日期：1994-03-01 00:00:00
