Abstract:
:The effects on fertility and reproductive wastage of 110 female Swiss/Webster mice and postnatal survival of their offspring were examined after exposure to either air, 0.4% isoflurane, or 0.1% isoflurane. Treatments were for 4 h daily for 2 weeks before and during pregnancy. In a second experiment, the effects on fertility of 54 male Swiss/Webster mice and on reproductive wastage of their unexposed mates were examined after 4-h daily exposures to either air, 0.4% isoflurane, or 0.1% isoflurane throughout spermatogenesis and during mating. There were no adverse reproductive effects in either experiment. The lack of toxicity of isoflurane is consistent with the results of other reproductive studies in animals that have examined chronic intermittent exposure to subanesthetic concentrations of halothane, enflurane, methoxyflurane, and nitrous oxide. They suggest that these and lower (trace) levels of anesthetic gases may not be the cause of the harmful reproductive effects said to occur in operating room personnel.
journal_name
Anesthesiologyjournal_title
Anesthesiologyauthors
Mazze RIdoi
10.1097/00000542-198512000-00017subject
Has Abstractpub_date
1985-12-01 00:00:00pages
663-7issue
6eissn
0003-3022issn
1528-1175journal_volume
63pub_type
杂志文章相关文献
ANESTHESIOLOGY文献大全abstract:BACKGROUND:Moxonidine, a novel imidazoline-alpha2-adrenergic receptor-selective analgesic, was recently identified as antinociceptive but has yet to be evaluated in neuropathic pain models. alpha2-adrenergic receptor-selective analgesics, and high-efficacy opioids, effectively inhibit neuropathic pain behaviors in rode...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-200009000-00026
更新日期:2000-09-01 00:00:00
abstract:BACKGROUND:This propensity score-matched cohort study evaluates the effect of anesthetic technique on a 30-day mortality after total hip or knee arthroplasty. METHODS:All patients who had hip or knee arthroplasty between January 1, 2003, and December 31, 2014, were evaluated. The principal exposure was spinal versus g...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0000000000001248
更新日期:2016-10-01 00:00:00
abstract::The effect of chronic renal failure (RF) on the pharmacokinetics of morphine was studied in nine patients with end-stage RF, aged 58 +/- 8 yr (SD), and in seven control patients, aged 58 +/- 15 yr, undergoing peripheral surgery under general anesthesia. All patients received 0.2 mg X kg-1 as an intravenous bolus injec...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-198703000-00011
更新日期:1987-03-01 00:00:00
abstract:BACKGROUND:The diagnosis of an acute malignant hyperthermia reaction by clinical criteria can be difficult because of the nonspecific nature and variable incidence of many of the clinical signs and laboratory findings. Development of a standardized means for estimating the qualitative likelihood of malignant hypertherm...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199404000-00008
更新日期:1994-04-01 00:00:00
abstract:BACKGROUND:Blood pressure (BP) monitoring with arterial waveform display requires an arterial cannula. We evaluated a new noninvasive device, Vasotrac (Medwave, Arden Hills, MN) that provides BP measurements approximately every 12-15 beats and displays pulse rate and a calibrated arterial waveform for each BP measureme...
journal_title:Anesthesiology
pub_type: 杂志文章,多中心研究
doi:10.1097/00000542-199909000-00021
更新日期:1999-09-01 00:00:00
abstract:BACKGROUND:Anesthetic drugs administered to immature animals may cause neurohistopathologic changes and alterations in behavior. The authors studied association between anesthetic exposure before age 4 yr and the development of reading, written language, and math learning disabilities (LD). METHODS:This was a populati...
journal_title:Anesthesiology
pub_type: 杂志文章,多中心研究
doi:10.1097/01.anes.0000344728.34332.5d
更新日期:2009-04-01 00:00:00
abstract:BACKGROUND:Despite the fact that obesity is a known risk factor for cardiovascular disease, many studies have failed to demonstrate that obesity is independently associated with an increased risk of cardiovascular morbidity and mortality in nondiabetic patients undergoing coronary artery bypass graft surgery. The autho...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-200603000-00010
更新日期:2006-03-01 00:00:00
abstract:BACKGROUND:Ventilator-associated pneumonia is a clear risk factor for acute lung injury which has been poorly described in trauma patients. This prospective study was undertaken to estimate the incidence of such ventilator-associated pneumonia leading to acute lung injury, the risk factors, and the associated morbidity...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-200602000-00006
更新日期:2006-02-01 00:00:00
abstract:BACKGROUND:Dexmedetomidine is a sedative with modest analgesic efficacy, whereas remifentanil is an opioid analgesic with modest sedative potency. Synergy is often observed when sedative-hypnotics are combined with opioid analgesics in anesthetic practice. A three-phase crossover trial was conducted to study the pharma...
journal_title:Anesthesiology
pub_type: 临床试验,杂志文章
doi:10.1097/ALN.0000000000002882
更新日期:2019-11-01 00:00:00
abstract::The treatment of venous air embolism by aspiration from central venous catheters is well established. However, some anesthesiologists prefer to use a pulmonary artery catheter to monitor patients undergoing a neurosurgical procedure in the sitting position. While offering certain advantages, pulmonary artery catheters...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-198801000-00017
更新日期:1988-01-01 00:00:00
abstract::Chronic muscle disuse decreases the sensitivity of skeletal muscle to nondepolarizing relaxants, such as metocurine (MTC). In this study, the authors determined whether chronic conditioning would produce the opposite effect and increase the sensitivity of skeletal muscle to MTC. Five dogs were exercised by daily runni...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-198906000-00015
更新日期:1989-06-01 00:00:00
abstract:BACKGROUND:3,4-Methylenedioxymethamphetamine (MDMA, "ecstasy") can mediate acute toxic effects such as muscle rigidity, metabolic acidosis, and hyperthermia. Because of close clinical similarities, an association between MDMA intoxication and malignant hyperthermia (MH) was suggested. The aim of this study was to inves...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-200311000-00020
更新日期:2003-11-01 00:00:00
abstract::To investigate the hemodynamic correlates of perioperative regional wall motion abnormalities (RWMA), we measured wall motion continuously via transesophageal echocardiography (TEE), and related RWMA to continuously measured hemodynamic indices of myocardial oxygen supply and demand (heart rate [HR] and systemic and p...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199011000-00002
更新日期:1990-11-01 00:00:00
abstract:BACKGROUND:The mechanisms that underlie the supraspinal central nervous system effects of systemic lidocaine are poorly understood and not solely explained by Na(+) channel blockade. Among other potential targets is the hyperpolarization-activated cation current, I(h), which is blocked by lidocaine in peripheral neuron...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0b013e31822ddf08
更新日期:2011-10-01 00:00:00
abstract::The occurrence of fasciculations following administration of agents is a well-known pharmacologic phenomenon. Using the cat soleus nerve-muscle preparation, intravenous neostigmine doses between 20-200 micrograms/kg evoked fasciculations in a dose-related manner. The data demonstrate that the fasciculations were the r...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-198712000-00011
更新日期:1987-12-01 00:00:00
abstract:BACKGROUND:Recent evidences have documented that several pharmacologic actions of alpha2-adrenoceptor agonists are mediated via activation of not only alpha2-adrenoceptors, but also by imidazoline receptors, which are nonadrenergic receptors in the central nervous system. However, the effect of imidazoline receptors on...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199710000-00032
更新日期:1997-10-01 00:00:00
abstract:BACKGROUND:Ulnar neuropathy is well-recognized as a potential complication of procedures performed on anesthetized patients. However, reported outcomes and risk factors for this problem are based on small series and anecdotes. METHODS:We retrospectively reviewed the perioperative courses of 1,129,692 consecutive patie...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:
更新日期:1994-12-01 00:00:00
abstract:BACKGROUND:Reduced spinal excitability contributes to the suppression of movement responses to noxious stimuli during the anesthetic state. This study examines and compares presynaptic and postsynaptic effects of two anesthetics in the human spinal cord. METHODS:The authors tested two parameters during the administrat...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/01.anes.0000282099.30437.46
更新日期:2007-10-01 00:00:00
abstract:BACKGROUND:Little is known about the influence of liver transplantation on the pharmacokinetics of most anesthetic drugs. The authors determined the pharmacokinetics of rocuronium during liver transplantation and examined whether variability in pharmacokinetics could explain variability in recovery of neuromuscular fun...
journal_title:Anesthesiology
pub_type: 临床试验,杂志文章
doi:10.1097/00000542-199706000-00012
更新日期:1997-06-01 00:00:00
abstract:BACKGROUND:Anesthetics are believed to alter functional connectivity across brain regions. However, network-level analyses of anesthesia, particularly in humans, are sparse. The authors hypothesized that propofol-induced loss of consciousness results in functional disconnection of human sensorimotor cortices underlying...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0000000000001940
更新日期:2018-02-01 00:00:00
abstract:BACKGROUND:Active sodium transport is the primary mechanism that drives alveolar fluid clearance. In the current study, the effects of exposure to halothane and isoflurane on alveolar fluid clearance in rats were evaluated. METHODS:Rats were exposed to either halothane (0.4% for 6 h or 2% for 2 h) or isoflurane (0.6% ...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199803000-00027
更新日期:1998-03-01 00:00:00
abstract::Local glucose consumption within specific brain structures in awake and halothane-anesthetized primates was studied using a quantitative autoradiographic technique for glucose (14C-deoxyglucose). In both awake and anesthetized animals, significant heterogeneity (one-way analysis of variance) in uptake of glucose was f...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-197802000-00004
更新日期:1978-02-01 00:00:00
abstract::Critically ill patients requiring mechanical ventilation are particularly susceptible to malnutrition. A knowledge of the energy requirements of these patients is essential in designing nutritional regimens. This study examines 45 resting energy-expenditure measurements performed in a group (n = 40) of postoperative, ...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-198606000-00001
更新日期:1986-06-01 00:00:00
abstract::Isoflurane has a lesser ability than halothane to induce contracture in malignant hyperthermia (MH) muscle in vitro. This does not necessarily imply that isoflurane is not as potent an MH trigger as halothane in vivo. A hypothesis was tested that in vitro treatment with Bay K 8644, an activator of both the dihydropyri...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199204000-00010
更新日期:1992-04-01 00:00:00
abstract:BACKGROUND:Pain and nausea are the most common challenges in postoperative recovery after mastectomy. Preventive measures include multimodal analgesia with preoperative glucocorticoid. The aim of this study was to investigate whether 24 mg of preoperative dexamethasone was superior to 8 mg on early recovery after maste...
journal_title:Anesthesiology
pub_type: 杂志文章,随机对照试验
doi:10.1097/ALN.0000000000003112
更新日期:2020-04-01 00:00:00
abstract::Perioperative myocardial ischemia is associated with an increased risk of perioperative myocardial infarction (PMI). Several attempts have been made to define intraoperative hemodynamic predictors of myocardial ischemia. In a canine preparation with coronary stenosis, a pressure rate quotient (PRQ = mean arterial pres...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199105000-00008
更新日期:1991-05-01 00:00:00
abstract:BACKGROUND:Autoregressive modeling with exogenous input of middle latency auditory evoked potentials (A-Line autoregressive index [AAI]) has been proposed for monitoring depth of anesthesia in adults. The aim of this study was to evaluate the performance of the AAI during induction of anesthesia with sevoflurane and re...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-200408000-00008
更新日期:2004-08-01 00:00:00
abstract::A carcinogen bioassay of enflurane was performed in Swiss/ICR mice. Two groups of weanling mice, each of 125 males and 125 females, were exposed to eigher a maximum tolerated dose of enflurane, 3000 ppm (0.3 per cent v/v) or compressed air for 4 hs per day, 5 days per week. After 52 weeks exposure, 25 males and 25 fem...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-198201000-00003
更新日期:1982-01-01 00:00:00
abstract:OBJECTIVE:The authors reviewed efficacy and safety data for ondansetron for preventing postoperative nausea and vomiting (PONV). METHODS:Systematically searched, randomized, controlled trials (obtained through MEDLINE, EMBASE, Biological Abstracts, manufacturer's database, manual searching of journals, and article ref...
journal_title:Anesthesiology
pub_type: 杂志文章,meta分析
doi:10.1097/00000542-199712000-00004
更新日期:1997-12-01 00:00:00
abstract:BACKGROUND:In animals, systemic and intrathecal administration of the alpha2 -adrenergic receptor agonist dexmedetomidine results in robust antinociceptive effects in models of heat pain. In humans, systemically administered dexmedetomidine is approved for sedating patients in the intensive care unit. However, whether ...
journal_title:Anesthesiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00000542-200409000-00024
更新日期:2004-09-01 00:00:00