Abstract:
:Radiosurgery is fundamentally the harnessing of energy and delivering it to a focal target for a therapeutic effect. The evolution of radiosurgical technology and practice has served toward refining methodologies for better conformal energy delivery. In the past, this has resulted in developing strategies for improved beam generation and delivery. Ultimately, however, our current instrumentation and treatment modalities may be approaching a practical limit with regard to further optimizing energy containment. In looking forward, several strategies are emerging to circumvent these limitations and improve conformal radiosurgery. Refinement of imaging techniques through functional imaging and nanoprobes for cancer detection may benefit lesion localization and targeting. Methods for enhancing the biological effect while reducing radiation-induced changes are being examined through dose fractionation schedules. Radiosensitizers and photosensitizers are being investigated as agents for modulating the biological response of tissues to radiation and alternative energy forms. Discovery of new energy modalities is being pursued through development of microplanar beams, free electron lasers, and high-intensity focused ultrasound. The exploration of these future possibilities will provide the tools for radiosurgical treatment of a broader spectrum of diseases for the next generation.
journal_name
Neurosurgeryjournal_title
Neurosurgeryauthors
Hoh DJ,Liu CY,Chen JC,Pagnini PG,Yu C,Wang MY,Apuzzo MLdoi
10.1227/01.neu.0000306089.22894.4esubject
Has Abstractpub_date
2007-12-01 00:00:00pages
1111-29; discussion 1129-30issue
6eissn
0148-396Xissn
1524-4040pii
00006123-200712000-00001journal_volume
61pub_type
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