Targeting the alpha 1 subunit of the sodium pump to combat glioblastoma cells.

abstract：OBJECTIVE:In meningioma surgery, the completeness of resection is of great importance with regard to prognosis and recurrence. This is more difficult in meningiomas en plaque and cranial base meningiomas, which often involve the bone of the cranial base. We present a case in which radioguided resection of a meningioma ...

journal_title：Neurosurgery

authors： Dammers R,Hsu SP,Krisht AF

更新日期：2009-03-01 00:00:00

abstract：OBJECTIVE:To assess acute and chronic histopathological changes observed in a swine arteriovenous malformation model after endovascular delivery of Embolyx E (Micro Therapeutics Inc., San Clemente, CA) and its organic solvent dimethyl sulfoxide (DMSO). To develop standard endovascular delivery techniques of Embolyx thr...

journal_title：Neurosurgery

authors： Murayama Y,Viñuela F,Ulhoa A,Akiba Y,Duckwiler GR,Gobin YP,Vinters HV,Greff RJ

更新日期：1998-11-01 00:00:00

abstract：:Using transcranial doppler ultrasonography, cerebral blood flow velocity was measured daily from both middle cerebral arteries in 121 patients who had suffered minor (n = 55), moderate (n = 16), or severe (n = 50) brain injury. Serial computed tomographic scans were performed to identify noncontusion-related infarctio...

journal_title：Neurosurgery

authors： Chan KH,Dearden NM,Miller JD

更新日期：1992-05-01 00:00:00

abstract：:A major limitation to the effective treatment of intrinsic mass lesions of the brain stem has been the inability to clearly define the pathological anatomy radiographically. The improved soft tissue resolution offered by magnetic resonance imaging, as compared with axial computed tomography, now makes it possible not ...

journal_title：Neurosurgery

authors： Heffez DS,Zinreich SJ,Long DM

更新日期：1990-11-01 00:00:00

abstract：:At least 300 000 sports-related concussions occur in the United States annually. With millions of American athletes, the long-term effects of repeated concussion or mild traumatic brain injury are an important topic. Unfortunately, there is a lack of strong data on the causality or prevalence of long-term effects amon...

journal_title：Neurosurgery

authors： Saigal R,Berger MS

更新日期：2014-10-01 00:00:00

abstract：OBJECTIVE:To assess the impact of vasospasm on costs, length of stay, and mortality among inpatients with aneurysmal subarachnoid hemorrhage. METHODS:We combined hospital accounting and physician billing data for a consecutive cohort of 198 patients who underwent surgical clipping or endovascular coiling for subarachn...

journal_title：Neurosurgery

authors： Chou CH,Reed SD,Allsbrook JS,Steele JL,Schulman KA,Alexander MJ

更新日期：2010-08-01 00:00:00

abstract：:It is well known that the Horsley-Clarke frame was developed and first used by Robert Henry Clarke and the pioneer neurosurgeon Victor Horsley in 1906 for making lesions in the central nervous system of animals. The Horsley-Clarke frame was extensively used throughout the next 4 decades for excitation and lesion produ...

journal_title：Neurosurgery

authors： Jensen RL,Stone JL,Hayne RA

更新日期：1996-03-01 00:00:00

abstract：OBJECTIVE:To systematically appraise the study design and quality of reporting of randomized controlled trials (RCTs) on neurosurgical procedures and to identify potential defects and biases. METHODS:Randomized controlled trials with at least five patients comparing any neurosurgical procedure against another procedur...

journal_title：Neurosurgery

authors： Vranos G,Tatsioni A,Polyzoidis K,Ioannidis JP

更新日期：2004-07-01 00:00:00

abstract：:We have recently shown that seizures induce significant and sustained elevations of thyrotropin-releasing hormone (TRH) in specific extrahypothalamic rat brain regions associated with epileptic foci including amygdala, hippocampus, pyriform cortex, and anterior cortex. Seizures were induced in dogs to further study th...

journal_title：Neurosurgery

authors： Shapiro S,Kubek M,Sanders S,Durbin S,Goodwin S,Javed T

更新日期：1992-11-01 00:00:00

abstract：OBJECTIVE:Brain injuries have been the most common direct cause of death among American football players since the annual recording of football-related deaths began in 1931. This study examines the 55-year experience with brain injury-related fatalities in American football from 1945 to 1999, including not only the inc...

journal_title：Neurosurgery

authors： Cantu RC,Mueller FO

更新日期：2003-04-01 00:00:00

abstract：OBJECTIVE AND IMPORTANCE:We describe a patient with a cavernous malformation within the trigeminal nerve at the nerve root entry zone who presented with trigeminal neuralgia. CLINICAL PRESENTATION:A 52-year-old woman sought treatment after experiencing dizziness and lancinating left facial pain for almost a year. Neur...

journal_title：Neurosurgery

authors： Deshmukh VR,Hott JS,Tabrizi P,Nakaji P,Feiz-Erfan I,Spetzler RF

更新日期：2005-03-01 00:00:00

abstract：BACKGROUND:Although favorable clinical outcomes have been reported for instrumented lumbar interbody fusion (LIF), adjacent segment degeneration (ASD) has been reported as a long-term complication after LIF. OBJECTIVE:To investigate ASD after instrumented LIF performed at a single level and only for the homogeneous di...

journal_title：Neurosurgery

authors： Bae JS,Lee SH,Kim JS,Jung B,Choi G

更新日期：2010-12-01 00:00:00

abstract：OBJECTIVE AND IMPORTANCE:Hypertrophic neuropathy of the cauda equina (HNCE) is a rare form of peripheral neuropathy. The diagnosis is complicated by an insidious clinical presentation and complex radiographic images. We present a case of HNCE caused by chronic inflammatory demyelinating polyneuropathy with symptomatic ...

journal_title：Neurosurgery

authors： Kretzer RM,Burger PC,Tamargo RJ

更新日期：2004-02-01 00:00:00

abstract：OBJECTIVE:We report on 32 neonates treated with ventriculosubgaleal (VSG) shunts to determine VSG shunt survival and associated complications. METHODS:Between 1993 and 1997, 37 VSG shunts were placed in 32 neonates when the cerebrospinal fluid (CSF) or the abdomen was considered unsuitable for ventriculoperitoneal shu...

journal_title：Neurosurgery

authors： Fulmer BB,Grabb PA,Oakes WJ,Mapstone TB

更新日期：2000-07-01 00:00:00

abstract：:An unusual case of benign stem glioma with a 15-year survival is presented. In spite of 12 years of clinical quiescence, a focus of the tumor in the upper brain stem was found at necropsy. Morphologically, the tumor was a cystic pilocytic astrocytoma. The few previously reported similar cases in the same location were...

journal_title：Neurosurgery

authors： Soffer D,Sahar A

更新日期：1982-04-01 00:00:00

abstract：BACKGROUND:Knowledge of the individual course of the optic radiations (ORs) is important to avoid postoperative visual deficits. Cadaveric studies of the visual pathways are limited because it has not been possible to separate the OR from neighboring tracts accurately and results may not apply to individual patients. D...

journal_title：Neurosurgery

authors： Wu W,Rigolo L,O'Donnell LJ,Norton I,Shriver S,Golby AJ

更新日期：2012-03-01 00:00:00

abstract：OBJECTIVE:Total brain water content changes in several cerebral pathological conditions and the measurement of brain water content are important for the selection of appropriate therapeutic procedures. We present a quantitative, in vivo, bioelectrical impedance analysis (BIA) method and propose its use for the accurate...

journal_title：Neurosurgery

authors： Grasso G,Alafaci C,Passalacqua M,Morabito A,Buemi M,Salpietro FM,Tomasello F

更新日期：2002-05-01 00:00:00

abstract：BACKGROUND:Although injury to the lumbar arteries during anterior spinal approaches is often encountered, there are few published articles regarding the relationship between the lumbar arteries and spinal cord ischemia. OBJECTIVE:To examine the morphology of the lumbar arteries and to emphasize their clinical importan...

journal_title：Neurosurgery

authors： Arslan M,Comert A,Acar HI,Ozdemir M,Elhan A,Tekdemir I,Tubbs RS,Ugur HC

更新日期：2011-03-01 00:00:00

abstract：:Cell therapy has been widely recognized as a promising strategy to enhance recovery in stroke survivors. However, despite an abundance of encouraging preclinical data, successful clinical translation remains elusive. As the field continues to advance, it is important to reexamine prior clinical trials in the context o...

journal_title：Neurosurgery

authors： Gu BJ,Kung DK,Chen HI

更新日期：2020-12-28 00:00:00

abstract：:The recently described multiple tumor suppressor 1/cyclin-dependent kinase inhibitor 2 (MTS1/CDKN2) gene, encoding the cyclin-dependent kinase 4 inhibitor p16, is mutated in a wide variety of tumor cell lines, including gliomas. To investigate the possible role of this gene in the genesis of the central nervous system...

journal_title：Neurosurgery

authors： Raffel C,Ueki K,Harsh GR 4th,Louis DN

更新日期：1995-05-01 00:00:00

abstract：OBJECTIVE:To further elucidate the importance of anatomic variations in morphology of the foramen magnum and associated clinical implications, we conducted a morphometric study. METHODS:Seventy-two dry skulls were used for this study. Digital images were obtained of the foramen magnum from an inferior view. These imag...

journal_title：Neurosurgery

authors： Tubbs RS,Griessenauer CJ,Loukas M,Shoja MM,Cohen-Gadol AA

更新日期：2010-02-01 00:00:00

abstract：OBJECTIVE:The purpose of this study was to test, in rabbits, the tightness of seven dural substitution materials commonly used in neurosurgery, i.e., Lyodura (B. Braun Melsungen AG, Melsungen, Germany), Tutoplast dura (Tutogen Medical, Inc., Parsippany, NJ), Tutoplast fascia lata (Tutogen Medical, Inc.), autologous per...

journal_title：Neurosurgery

authors： Filippi R,Derdilopoulos A,Heimann A,Krummenauer F,Perneczky A,Kempski O

更新日期：2000-06-01 00:00:00

abstract：:Harvey Cushing developed an illness in the last months of World War I that made it impossible for him to operate and forced him to bed for over a month. The features of Cushing's malady included symmetrical weakness, numbness, and paresthesias of the hands and feet, areflexia, bilateral facial paresis, diplopia, and f...

journal_title：Neurosurgery

authors： Reich SG

更新日期：1987-08-01 00:00:00

abstract：OBJECTIVE:Endoscopy usually is avoided in patients without hydrocephalus because of presumed difficulties with ventricular cannulation and intraventricular navigation. The feasibility of endoscopic tumor management in patients without hydrocephalus was assessed on the basis of achieving the surgical objective and asses...

journal_title：Neurosurgery

authors： Souweidane MM

更新日期：2005-10-01 00:00:00

abstract：OBJECTIVE:It is postulated that reactive oxygen species may play an inductive role in neuro-oncogenesis. However, data pertaining to the redox state of astrocytomas are limited, which prompted us to undertake this study. METHODS:Intraoperative snap-frozen samples were obtained from the surface and core of 8 low-grade ...

journal_title：Neurosurgery

authors： Louw DF,Bose R,Sima AA,Sutherland GR

更新日期：1997-11-01 00:00:00

abstract：:A newly designed cottonoid is fixed to the tip of the suction device by the negative pressure. It is especially useful during microsurgical procedures in areas crowded with neurovascular elements. The advantage of pressure-mounted cottonoids lies in the protection provided to the brain and neurovascular elements durin...

journal_title：Neurosurgery

authors： Arbit E

更新日期：1982-12-01 00:00:00

abstract：OBJECTIVE:Vascular remodeling via apoptotic mechanisms is an important factor in vascular diseases. c-Jun amino-terminal kinase (JNK) is a member of the mitogen-activated protein kinase family and initiates apoptosis mainly via phosphorylation of the c-Jun transcription factor. We performed this study to clarify the ro...

journal_title：Neurosurgery

authors： Takagi Y,Ishikawa M,Nozaki K,Yoshimura S,Hashimoto N

更新日期：2002-10-01 00:00:00

abstract：:INNOVATION IS THE driving force behind progress in neurosurgery. Most significant innovations require commercialization to ensure appropriate development and ultimate distribution to patients. There are several key factors that determine whether a particular innovation is likely to be commercially successful. Relation...

journal_title：Neurosurgery

authors： Firlik AD,Lowry DW,Levy AJ,Hirsch RC

更新日期：2000-07-01 00:00:00

abstract：BACKGROUND:Resection of cerebellopontine angle (CPA) meningiomas may result in significant neurological morbidity. Radiosurgery offers a minimally invasive alternative to surgery. OBJECTIVE:To evaluate, in a multicenter cohort study, the outcomes of patients harboring CPA meningiomas who underwent Gamma Knife radiosur...

journal_title：Neurosurgery

authors： Ding D,Starke RM,Kano H,Nakaji P,Barnett GH,Mathieu D,Chiang V,Omay SB,Hess J,McBride HL,Honea N,Lee JY,Rahmathulla G,Evanoff WA,Alonso-Basanta M,Lunsford LD,Sheehan JP

更新日期：2014-10-01 00:00:00

abstract：:Although the shapes of velocity waveforms obtained with transcranial Doppler examination can indicate such abnormalities as increased intracranial pressure and proximal arterial compromise, the significance of unusual waveform morphologies is often obscure. In this report, we describe four cases in which an unusual wa...

journal_title：Neurosurgery

authors： Giller CA,Giller AM,Batjer HH,Kopitnik TA

更新日期：1994-06-01 00:00:00