Abstract:
OBJECTIVE:Total brain water content changes in several cerebral pathological conditions and the measurement of brain water content are important for the selection of appropriate therapeutic procedures. We present a quantitative, in vivo, bioelectrical impedance analysis (BIA) method and propose its use for the accurate assessment of brain water content among human subjects. METHODS:Cerebral BIA is based on the conduction of an applied current in the brain parenchyma. Application of an excitatory current of 800 microA at 50 kHz, via two electrodes placed on the eyelids with the eyes closed, and detection of the voltage drop with two electrodes placed in the suboccipital region allow brain resistance and reactance to be measured. By means of an equation that considers cranial circumference and resistance, it is possible to quantify the total brain water content, expressed as the bioelectrical volume. Cerebral BIA was performed with a series of healthy volunteers (n = 100), for determination of average brain water content values. The method was then applied to 50 patients with brain tumors (n = 20), intracranial hemorrhage (n = 16), or hydrocephalus (n = 14), for assessment of changes in global brain water contents. Data were compared with those obtained for healthy volunteers. RESULTS:Statistically significant differences (P < 0.001) were observed between the two groups. Mean brain water content values (expressed as bioelectrical volume values) were 38.2 +/- 3.9 cm2/Omega for healthy volunteers and 67.7 +/- 13.1 cm2/Omega for patients with cerebral pathological conditions. Statistically significant differences (P < 0.05) were also observed among patients with cerebral pathological conditions. CONCLUSION:The results of this study suggest that BIA, applied to the cerebral parenchyma, is a valid method for the prediction of brain water contents under both normal and pathological conditions. However, further studies are needed to establish whether it is sensitive and reliable enough for future clinical applications.
journal_name
Neurosurgeryjournal_title
Neurosurgeryauthors
Grasso G,Alafaci C,Passalacqua M,Morabito A,Buemi M,Salpietro FM,Tomasello Fdoi
10.1097/00006123-200205000-00023keywords:
subject
Has Abstractpub_date
2002-05-01 00:00:00pages
1064-72; discussion 1072-4issue
5eissn
0148-396Xissn
1524-4040journal_volume
50pub_type
杂志文章相关文献
NEUROSURGERY文献大全abstract:BACKGROUND:Cerebrovascular autoregulation (CA) is an important hemodynamic mechanism that protects the brain against inappropriate fluctuations in cerebral blood flow in the face of changing cerebral perfusion pressure. Temporal CA failure is associated with worse outcomes in various acute neurological diseases. An int...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/NEU.0000000000001192
更新日期:2016-07-01 00:00:00
abstract:OBJECTIVE:The high rate of mutagenesis in malignant cells has been considered to be a primary factor in the appearance of chemotherapy-resistant cell clones in glioblastomas. Quinacrine binds strongly to deoxyribonucleic acid, preventing mutagenesis. We investigated whether quinacrine could improve carmustine therapy i...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1097/00006123-200110000-00033
更新日期:2001-10-01 00:00:00
abstract:OBJECTIVE:In recent years, stereotactic radiosurgery has been growing in popularity as a treatment modality for metastatic disease to the brain. The technique has advantages of reduced cost and low morbidity compared with open surgical treatment. Furthermore, it avoids the potential cognitive side effects of fractionat...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1097/00006123-200008000-00003
更新日期:2000-08-01 00:00:00
abstract::Oligodendrogliomas occur primarily in the cerebral hemispheres of adults. A rare case of an oligodendroglioma in the cerebellum of a child is presented. The tendency for oligodendroglioma to metastasize through the cerebrospinal fluid (CSF) is reviewed and emphasized. A recommendation for CSF cytology and possible spi...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/00006123-198005000-00010
更新日期:1980-05-01 00:00:00
abstract:INTRODUCTION:Isolated spinal aneurysms are rare; only a few have been reported. To the best of our knowledge, this series represents the largest experience with four ruptured spinal aneurysms, all of which were treated surgically. METHODS:Clinical information from the hospital charts and diagnostic images of four pati...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/01.neu.0000186010.34779.10
更新日期:2005-12-01 00:00:00
abstract:OBJECTIVE:The objective was to examine the microsurgical anatomy basic to the microsurgical and endovascular management of lesions involving the dural arteries. METHODS:Adult cadaveric heads and skulls were examined using the magnification provided by the surgical microscope to define the origin, course, and distribut...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/01.neu.0000144823.94402.3d
更新日期:2005-04-01 00:00:00
abstract::Extracranial-intracranial arterial bypass procedures provide important augmentation of collateral circulation to cortical areas rendered potentially ischemic by therapeutic occlusion of major branches of the circle of Willis. Although the case studies reported to date in general reflect positively on this use of the b...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:
更新日期:1980-02-01 00:00:00
abstract::Research examining the neurobehavioral outcome after mild head injury has yielded inconsistent and contradictory findings. Such findings have been attributed to a variety of methodological weaknesses, such as failure to consider the preinjury status of the patient, lack of control groups, and variability in outcome ti...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1097/00006123-199602000-00002
更新日期:1996-02-01 00:00:00
abstract:OBJECTIVE:Symptomatic dissections of the cervical carotid artery (CCA) can be spontaneous or secondary to trauma and may be associated with pseudoaneurysms. Surgical treatment is often difficult or unavailable. We report the successful use of endovascular stents in the treatment of symptomatic dissection of the CCA. M...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1097/00006123-199904000-00037
更新日期:1999-04-01 00:00:00
abstract::Two patients presented with syringomyelia, each unusual. After neuroradiographic diagnosis with delayed metrizamide computed tomography (CT) or magnetic resonance imaging (MRI), an interesting diagnostic question arose. A percutaneous minidose metrizamide endomyelographic CT (PMDMECT) study clarified each situation an...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/00006123-198703000-00013
更新日期:1987-03-01 00:00:00
abstract::Premature closure of the metopic suture results in a deformity ranging from a minor variation to a severe cosmetic deformity. The three principal abnormalities comprising metopic synostosis are trigonocephaly secondary to the restriction of growth of both frontal bones, deficient lateral supraorbital rims, and hypotel...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/00006123-198608000-00008
更新日期:1986-08-01 00:00:00
abstract:OBJECTIVE:Intracranial dural arteriovenous fistulae (DAVFs) can present as disabling intracranial hemorrhage. The aim of this study was to investigate the independent effects of specific demographic and clinical variables on hemorrhagic presentation in patients with DAVFs. METHODS:All patients with DAVFs evaluated at ...
journal_title:Neurosurgery
pub_type: 临床试验,杂志文章
doi:10.1227/01.neu.0000317311.69697.fc
更新日期:2008-03-01 00:00:00
abstract::Surgical resection of cerebral arteriovenous malformations is often complicated by persistent bleeding from the nidus, which is difficult to manage. It has often been mentioned that the difficulty of hemostasis is caused by the fragile and pathological nature of vessels of the nidus. This may be one reason, but I hypo...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1097/00006123-200106000-00018
更新日期:2001-06-01 00:00:00
abstract:OBJECTIVE AND IMPORTANCE:Abducens nerve palsy is a rare and reversible complication associated with percutaneous radiofrequency trigeminal rhizolysis. CLINICAL PRESENTATION:An 86-year-old man developed an abducens nerve palsy immediately after undergoing percutaneous radiofrequency trigeminal rhizolysis for severe tri...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1097/00006123-199809000-00134
更新日期:1998-09-01 00:00:00
abstract:OBJECTIVE:For adult meningiomas, the staining index (SI) for the anti-Ki-67 monoclonal antibody MIB-1 is well correlated with histological atypia and tumor recurrence. MIB-1 SIs for meningiomas in the pediatric population have not been previously reported. Meningiomas tend to be more histologically aggressive and to re...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1097/00006123-200103000-00027
更新日期:2001-03-01 00:00:00
abstract:BACKGROUND:Although various strategies for prevention of brain disease have been implemented, no substance has been found to be advantageous for prophylaxis against brain injury. OBJECTIVE:While previous work in our laboratory and others have shown positive effects using the omega-3 fatty acid docosahexaenoic acid (DH...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/NEU.0b013e3181ff692b
更新日期:2011-02-01 00:00:00
abstract:OBJECTIVE:We describe a case of sickle cell anemia and multiple intracranial aneurysms and review the English-language-reported cases of sickle cell disease associated with intracranial aneurysms proven angiographically or by autopsy, to assess whether there are associations with aneurysm multiplicity and sites of aneu...
journal_title:Neurosurgery
pub_type: 杂志文章,评审
doi:10.1097/00006123-199805000-00007
更新日期:1998-05-01 00:00:00
abstract::We recorded somatosensory evoked potentials (SEPs) from the skin surface and spinal evoked potentials (SpEP) from the posterior epidural space after median nerve stimulation in 11 patients with cervical syringomyelia. We compared SEPs with SpEP to assess the possible feasibility of using these techniques to localize t...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/00006123-199202000-00011
更新日期:1992-02-01 00:00:00
abstract:OBJECTIVE:The authors tested the hypothesis that among Grade II astrocytomas with a particularly long seizure history, a subgroup is hidden with a different prognosis and possibly histological characteristics. To do so, clinical and histological characteristics of two groups of World Health Organization Grade II astroc...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/01.neu.0000129546.38675.1b
更新日期:2004-08-01 00:00:00
abstract::Neurosurgery at the University of Michigan was established as a specialty three-quarters of a century ago by Max Minor Peet. It developed under the successive leadership of Edgar Allan Kahn, Richard Coy Schneider, and Julian T. Hoff. Each has made unique contributions to the program, which has a strong tradition of te...
journal_title:Neurosurgery
pub_type: 传,历史文章,杂志文章
doi:10.1227/00006123-199507000-00017
更新日期:1995-07-01 00:00:00
abstract:BACKGROUND:A piezo actuator-driven pulsed water jet (ADPJ) system is a novel surgical instrument that enables dissection of tissue without thermal damage. It can potentially resect intra-axial lesions while preserving neurological function. OBJECTIVE:To report our first experience of applying an ADPJ system to brain a...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/NEU.0000000000000867
更新日期:2015-09-01 00:00:00
abstract:BACKGROUND:Older age has been associated with worse outcomes in low-grade gliomas (LGGs). Given their rarity in the older population, determining optimal treatment plans and patient outcomes remains difficult. OBJECTIVE:To retrospectively study LGG survival outcomes in an older population stratified by molecular genet...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1093/neuros/nyy149
更新日期:2019-02-01 00:00:00
abstract:OBJECTIVE:The most important treatment options for meningiomas are microsurgery, radiotherapy, and gamma knife radiosurgery (GKRS). The efficacy of GKRS in terms of local tumor control and tumor volume (TV) reduction can best be determined by accurate analysis of changes in tumor size in pre- and post-GKRS images. In t...
journal_title:Neurosurgery
pub_type: 临床试验,杂志文章
doi:10.1227/01.NEU.0000279999.95953.EA
更新日期:2007-08-01 00:00:00
abstract:BACKGROUND:Magnetic resonance with diffusion tensor image (DTI) may be able to estimate trajectories compatible with subcortical tracts close to brain lesions. A limit of DTI is brain shifting (movement of the brain after dural opening and tumor resection). OBJECTIVE:To calculate the brain shift of trajectories compat...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/NEU.0b013e31821a8555
更新日期:2011-09-01 00:00:00
abstract::Glutamate antagonists are the most powerful neuroprotective drugs in laboratory studies of focal cerebral ischemia. Because the majority of clinical conditions in which focal brain ischemia occurs are associated with high intracranial pressure (ICP), we have used the rat acute subdural hematoma model to evaluate the e...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/00006123-199407000-00016
更新日期:1994-07-01 00:00:00
abstract:OBJECTIVE:Subarachnoid hemorrhage (SAH) predisposes patients to excessive natriuresis and volume contraction. We studied the effects of postoperative administration of 5% albumin solution on sodium balance and blood volume after SAH. We also sought to identify physiological variables that influence renal sodium excreti...
journal_title:Neurosurgery
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00006123-199804000-00048
更新日期:1998-04-01 00:00:00
abstract:OBJECTIVE:To determine the clinical presentation, imaging characteristics, microscopic and ultrastructural characteristics, and treatment outcomes of patients with clinically silent pituitary corticotroph adenomas. METHODS:All silent corticotroph adenomas diagnosed at the Mayo Clinic during the years 1975 through 1997...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1097/00006123-200009000-00039
更新日期:2000-09-01 00:00:00
abstract::Stereotactic instillation of absolute alcohol into the sella turcica for pituitary destruction was carried out in 29 patients divided into two groups. Seventeen with prostatic carcinoma underwent a total of 19 injections with 94% good to excellent results that persisted throughout the remainder of the patient's life-s...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/00006123-198003000-00006
更新日期:1980-03-01 00:00:00
abstract:BACKGROUND:Risk factors for poor quality of life (QOL) after subarachnoid hemorrhage (SAH) remain poorly described. OBJECTIVE:To identify the frequency and predictors of poor QOL 1 year after SAH. METHODS:We studied 1-year QOL in a prospectively collected cohort of 1181 consecutively admitted SAH survivors between Ju...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/NEU.0000000000001042
更新日期:2016-02-01 00:00:00
abstract::Premature infants weighing under 1500 g are now surviving because of technical and medical advances in the field of neonatology. Up to 70% of these babies will have intracranial hemorrhages. The management of posthemorrhagic hydrocephalus in these children with multiple other medical problems has thus become quite sig...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/00006123-198011000-00007
更新日期:1980-11-01 00:00:00