Neurosurgery at the University of Michigan.


:Neurosurgery at the University of Michigan was established as a specialty three-quarters of a century ago by Max Minor Peet. It developed under the successive leadership of Edgar Allan Kahn, Richard Coy Schneider, and Julian T. Hoff. Each has made unique contributions to the program, which has a strong tradition of teaching, research, and patient care. This article traces the development of the training program in neurosurgery at Michigan, focusing on its historical background, past accomplishments, present structure, and future directions.






Hoff JT,Taren JA




Has Abstract


1995-07-01 00:00:00












  • Preliminary report: intracranial cholinergic drug infusion in patients with Alzheimer's disease.

    abstract::After toxicity studies in dogs, a preliminary feasibility trial of the continuous intracranial infusion of a muscarinic agonist was begun in four patients with biopsy-documented Alzheimer's disease. During the last 8 months, a totally implantable infusion system has been used to deliver bethanechol chloride into the c...


    pub_type: 临床试验,杂志文章


    authors: Harbaugh RE,Roberts DW,Coombs DW,Saunders RL,Reeder TM

    更新日期:1984-10-01 00:00:00

  • External validation of the international mission for prognosis and analysis of clinical trials model and the role of markers of coagulation.

    abstract:BACKGROUND:Markers of coagulation have shown to have important value in predicting traumatic brain injury outcome. OBJECTIVE:To externally validate and investigate the role of markers of coagulation for outcome prediction by using the International Mission for Prognosis and Analysis of Clinical Trials (IMPACT) model w...


    pub_type: 杂志文章


    authors: Raj R,Siironen J,Kivisaari R,Hernesniemi J,Tanskanen P,Handolin L,Skrifvars MB

    更新日期:2013-08-01 00:00:00

  • A novel murine elastase saccular aneurysm model for studying bone marrow progenitor-derived cell-mediated processes in aneurysm formation.

    abstract:BACKGROUND:Although there are several large-species animal models for saccular aneurysms, there is a need for a simple, reproducible saccular aneurysm model in mice. OBJECTIVE:To develop a murine saccular aneurysm model, which replicates key characteristics that occur in the formation of human cerebral aneurysms. MET...


    pub_type: 杂志文章


    authors: Hoh BL,Velat GJ,Wilmer EN,Hosaka K,Fisher RC,Scott EW

    更新日期:2010-03-01 00:00:00

  • The use of fibrin glue to stop venous bleeding in the epidural space, vertebral venous plexus, and anterior cavernous sinus: technical note.

    abstract:OBJECTIVE:Various techniques have been used to stop venous bleeding from the epidural space, vertebral venous plexus, and cavernous sinus. Here, we describe our experience with the use of fibrin glue to stop venous bleeding in these areas. METHODS:During the last 8 years, the senior author (LNS) has used injection of ...


    pub_type: 杂志文章,评审


    authors: Sekhar LN,Natarajan SK,Manning T,Bhagawati D

    更新日期:2007-09-01 00:00:00

  • Epilepsy surgery in children with electrical status epilepticus in sleep.

    abstract:OBJECTIVE:Pediatric epilepsy surgery candidates with unilateral congenital or early-acquired brain lesions may present with refractory seizures and generalized electroencephalographic features such as electrical status epilepticus in sleep (ESES). The purpose of our study was to review the clinical presentation, neuroi...


    pub_type: 杂志文章


    authors: Loddenkemper T,Cosmo G,Kotagal P,Haut J,Klaas P,Gupta A,Lachhwani DK,Bingaman W,Wyllie E

    更新日期:2009-02-01 00:00:00

  • Postoperative infection may influence survival in patients with glioblastoma: simply a myth?

    abstract:BACKGROUND:It is a prevalent myth that a postoperative infection may actually confer a survival advantage in patients with malignant glioma. This contention is based largely on anecdotal reports. Recently, a single-center study showed there was no survival advantage in those patients who had glioblastoma with postopera...


    pub_type: 杂志文章


    authors: De Bonis P,Albanese A,Lofrese G,de Waure C,Mangiola A,Pettorini BL,Pompucci A,Balducci M,Fiorentino A,Lauriola L,Anile C,Maira G

    更新日期:2011-10-01 00:00:00

  • Technique, Results, and Complications Related to Robot-Assisted Stereoelectroencephalography.

    abstract:BACKGROUND:Robot-assisted stereoelectroencephalography (SEEG) may represent a simplified, precise, and safe alternative to the more traditional SEEG techniques. OBJECTIVE:To report our clinical experience with robotic SEEG implantation and to define its utility in the management of patients with medically refractory e...


    pub_type: 杂志文章


    authors: González-Martínez J,Bulacio J,Thompson S,Gale J,Smithason S,Najm I,Bingaman W

    更新日期:2016-02-01 00:00:00

  • The effects of diffuseness and deep perforating artery supply on outcomes after microsurgical resection of brain arteriovenous malformations.

    abstract:OBJECTIVE:Diffuse arteriovenous malformations (AVM) have non-compact niduses, irregular margins, and intervening brain parenchyma. Deep perforating arteries often contribute to the ragged border of these diffuse AVMs. We hypothesized that diffuseness and deep perforator supply increase the difficulties and risks associ...


    pub_type: 临床试验,杂志文章


    authors: Du R,Keyoung HM,Dowd CF,Young WL,Lawton MT

    更新日期:2007-04-01 00:00:00

  • Iatrogenic vertebrobasilar insufficiency after surgery of the subclavian or brachial artery: review of three cases.

    abstract:OBJECTIVE AND IMPORTANCE:Vertebrobasilar insufficiency resulting from disease of the subclavian artery is well recognized. Usually, this occurs as the "subclavian steal" syndrome in the context of chronic subclavian stenosis and is consequently well tolerated because of collateralization. Acute disruption of the hemody...


    pub_type: 杂志文章


    authors: Amar AP,Levy ML,Giannotta SL

    更新日期:1998-12-01 00:00:00

  • Vittorio Marchi, MD (1851-1908): an unsung pioneer of neuroscience.

    abstract::Vittorio Marchi was an Italian neuroscientist who lived during the second half of the 19th century. He is generally remembered for developing a novel staining method to trace the degeneration of nervous fibers in lesions of the central nervous system. This osmium-based method was used worldwide for approximately a cen...


    pub_type: 传,历史文章,杂志文章


    authors: Talamonti G,D'Aliberti G,Debernardi A,Innocenti G

    更新日期:2013-11-01 00:00:00

  • The rete mirabile of the cranial base: a millenary legend.

    abstract::The rete mirabile, a vascular network assumed to give origin to the intracranial segments of the internal carotid arteries, was interpreted by Galen as the key station for the conversion of the "vital spirit" into the "animal spirit." According to this interpretation, the rete was determinant either in sustaining the ...


    pub_type: 传,历史文章,杂志文章


    authors: Viale G

    更新日期:2006-06-01 00:00:00

  • Statin use was not associated with less vasospasm or improved outcome after subarachnoid hemorrhage.

    abstract:OBJECTIVE:The development of delayed ischemia caused by cerebral vasospasm remains a common cause of morbidity and mortality after aneurysmal subarachnoid hemorrhage. Preliminary studies suggest that 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) may decrease the risk of vasospasm, but additional ...


    pub_type: 杂志文章


    authors: Kramer AH,Gurka MJ,Nathan B,Dumont AS,Kassell NF,Bleck TP

    更新日期:2008-02-01 00:00:00

  • Stereotactic radiosurgery for vestibular schwannomas in patients with neurofibromatosis type 2: an analysis of tumor control, complications, and hearing preservation rates.

    abstract:OBJECTIVE:Vestibular schwannomas present significant management challenges in patients with neurofibromatosis Type 2 (NF2). We evaluated the results of gamma knife radiosurgery for the management of these tumors, focusing on tumor response, hearing preservation, and other factors affecting outcomes. METHODS:Stereotact...


    pub_type: 临床试验,杂志文章


    authors: Mathieu D,Kondziolka D,Flickinger JC,Niranjan A,Williamson R,Martin JJ,Lunsford LD

    更新日期:2007-03-01 00:00:00

  • Transcranial epidural approach to pituitary tumors extending beyond the sella.

    abstract:OBJECTIVE:The treatment of residual and/or recurrent pituitary tumors, initially operated on through transsphenoidal and/or transcranial approaches, required a new single approach that would make it possible to excise the tumor from the sella and from the neighboring regions. Surgical complications, such as pneumatocep...


    pub_type: 杂志文章


    authors: Dolenc VV

    更新日期:1997-09-01 00:00:00

  • Characterization of contractile responses to endothelin in human cerebral arteries: implications for cerebral vasospasm.

    abstract::Cerebral vascular tone is modulated, at least in part, by the vascular endothelium. This probably results from a balance between the release of the endothelium-derived relaxing factor(s) and the endothelium-derived constricting factor(s) (e.g., endothelin). The time course of the induction and the decay of these mutua...


    pub_type: 杂志文章


    authors: Papadopoulos SM,Gilbert LL,Webb RC,D'Amato CJ

    更新日期:1990-05-01 00:00:00

  • Cortical stimulation and epileptic seizure: a study of the potential risk in primates.

    abstract:OBJECTIVE:The recent successful development of chronic stimulation of the motor cortex as a treatment for neuropathic and central pain does not exclude the possibility of eventual side effects, such as epileptic seizure or a lowering of the epileptic threshold. This study evaluates the behavioral and electroencephalogr...


    pub_type: 杂志文章


    authors: Bezard E,Boraud T,Nguyen JP,Velasco F,Keravel Y,Gross C

    更新日期:1999-08-01 00:00:00

  • Clinical evaluation and follow-up outcome of diffusion tensor imaging-based functional neuronavigation: a prospective, controlled study in patients with gliomas involving pyramidal tracts.

    abstract:OBJECTIVE:To evaluate diffusion tensor imaging (DTI)-based functional neuronavigation in surgery of cerebral gliomas with pyramidal tract (PT) involvement with respect to both perioperative assessment and follow-up outcome. METHODS:A prospective, randomized controlled study was conducted between 2001 and 2005. A conse...


    pub_type: 杂志文章,随机对照试验


    authors: Wu JS,Zhou LF,Tang WJ,Mao Y,Hu J,Song YY,Hong XN,Du GH

    更新日期:2007-11-01 00:00:00

  • Endovascular therapy of very small aneurysms of the anterior communicating artery: five-fold increased incidence of rupture.

    abstract:BACKGROUND:Intraprocedural rupture is a dangerous complication of endovascular treatment. Small ruptured anterior communicating artery (ACoA) aneurysms and microaneurysms present a challenge for both surgical and endovascular therapies to achieve obliteration. An understanding of the complication rates of treating rupt...


    pub_type: 杂志文章,多中心研究


    authors: Schuette AJ,Hui FK,Spiotta AM,Obuchowski NA,Gupta R,Moskowitz SI,Tong FC,Dion JE,Cawley CM

    更新日期:2011-03-01 00:00:00

  • Delayed surgical resection reduces intraoperative blood loss for embolized meningiomas.

    abstract:OBJECTIVE:Embolization before surgical resection of tumors has been demonstrated to reduce intraoperative blood loss, but the optimal time that should elapse between embolization and tumor resection has not been established. We evaluated whether immediate surgical resection (< or =24 h) after embolization or delayed su...


    pub_type: 杂志文章


    authors: Chun JY,McDermott MW,Lamborn KR,Wilson CB,Higashida R,Berger MS

    更新日期:2002-06-01 00:00:00

  • Extracranial-intracranial vein graft bypass for giant intracranial aneurysm surgery for pediatric patients: two technical case reports.

    abstract:OBJECTIVE AND IMPORTANCE:Herein we describe two cases of extracranial-intracranial vein graft bypasses for the treatment of giant intracranial aneurysms in prepubertal pediatric patients. One patient is, we think, the youngest patient reported in the literature to have been successfully treated in such a manner, with a...


    pub_type: 杂志文章


    authors: Zhang YJ,Barrow DL,Day AL

    更新日期:2002-03-01 00:00:00

  • Volumetric stereotaxy and the supratentorial occipitosubtemporal approach in the resection of posterior hippocampus and parahippocampal gyrus lesions.

    abstract:OBJECTIVE:Resection of intracranial tumors in the posterior hippocampus and the parahippocampal gyrus can be associated with significant morbidity because of the parenchymal resection and the cortical retraction often required in gaining access to this infrequently explored region. With the use of image guidance, the o...


    pub_type: 杂志文章


    authors: Russell SM,Kelly PJ

    更新日期:2002-05-01 00:00:00

  • Roles of estrogen in the formation of intracranial aneurysms in ovariectomized female mice.

    abstract:BACKGROUND:Epidemiological studies have indicated that postmenopausal women have a higher incidence of intracranial aneurysms than men in the same age group. OBJECTIVE:To investigate whether estrogen or estrogen receptors (ERs) mediate protective effects against the formation of intracranial aneurysms. METHODS:Intrac...


    pub_type: 杂志文章


    authors: Tada Y,Makino H,Furukawa H,Shimada K,Wada K,Liang EI,Murakami S,Kudo M,Kung DK,Hasan DM,Kitazato KT,Nagahiro S,Lawton MT,Hashimoto T

    更新日期:2014-12-01 00:00:00

  • Occurrence, Risk Factors, and Time Trends for Late Reoperations due to Degenerative Cervical Spine Disease: A Finnish National Register Study of 19 377 Patients Operated on Between 1999 and 2015.

    abstract:BACKGROUND:Surgery for degenerative cervical spine disease has escalated since the 1990s. Fusion has become the mainstay of surgery despite concerns regarding adjacent segment degeneration. The patient-specific trends in reoperations have not been studied previously. OBJECTIVE:To analyze the occurrence, risk factors, ...


    pub_type: 杂志文章


    authors: Kotkansalo A,Leinonen V,Korajoki M,Korhonen K,Rinne J,Malmivaara A

    更新日期:2020-12-28 00:00:00

  • Intracranial hemangiopericytoma: patterns of failure and the role of radiation therapy.

    abstract:BACKGROUND:Meningeal hemangiopericytoma (M-HPC) is a rare entity. OBJECTIVE:To characterize our institutional experience in treating M-HPC. METHODS:We reviewed the medical records of patients with M-HPC evaluated at The University of Texas M.D. Anderson Cancer Center between 1979 and 2009. RESULTS:We identified 63 p...


    pub_type: 杂志文章


    authors: Ghia AJ,Chang EL,Allen PK,Mahajan A,Penas-Prado M,McCutcheon IE,Brown PD

    更新日期:2013-10-01 00:00:00

  • Polyamine and prostaglandin markers in focal cerebral ischemia.

    abstract::This study examines the pathophysiology of stroke secondary to focal cerebral ischemia. The interaction of arachidonic acid metabolites and polyamines, a class of ubiquitous ornithine-derived molecules with important membrane effects on edema, Ca++-dependent endocytosis, platelet function, and prostaglandin (PG) forma...


    pub_type: 杂志文章


    authors: Dempsey RJ,Roy MW,Meyer K,Tai HH,Olson JW

    更新日期:1985-10-01 00:00:00

  • Whole Sella vs Targeted Stereotactic Radiosurgery for Acromegaly: A Multicenter Matched Cohort Study.

    abstract:BACKGROUND:Targeted stereotactic radiosurgery (SRS) with sparing of the residual pituitary is the traditional radiosurgical method for pituitary adenomas. Whole-sella SRS is an alternative choice for radiologically indeterminate or large adenomas, the safety and efficacy of which has yet to be determined. OBJECTIVE:To...


    pub_type: 杂志文章,多中心研究


    authors: Taylor DG,Janssen A,Ding D,Xu Z,Mehta GU,Liscak R,Kano H,Kosak M,Martinez-Moreno N,Hobbs L,Chen CJ,Grills IS,Mathieu D,Lunsford LD,Vance ML,Sheehan JP

    更新日期:2020-05-01 00:00:00

  • Market-Based Health Care in Specialty Surgery: Finding Patient-Centered Shared Value.

    abstract::: The US health care system is struggling with rising costs, poor outcomes, waste, and inefficiency. The Patient Protection and Affordable Care Act represents a substantial effort to improve access and emphasizes value-based care. Value in health care has been defined as health outcomes for the patient per dollar spen...


    pub_type: 杂志文章,评审


    authors: Smith TR,Rambachan A,Cote D,Cybulski G,Laws ER

    更新日期:2015-10-01 00:00:00

  • Beneficial effect of subsequent lesion procedures after nonresponse to initial cingulotomy for severe, treatment-refractory obsessive-compulsive disorder.

    abstract:BACKGROUND:Anterior cingulotomy (AC) can be an effective therapy for patients with severe obsessive-compulsive disorder who are refractory to traditional medical therapy. For patients who do not respond to AC, the benefit of additional lesion procedures vs continued medical management remains unknown. OBJECTIVE:To det...


    pub_type: 杂志文章


    authors: Bourne SK,Sheth SA,Neal J,Strong C,Mian MK,Cosgrove GR,Eskandar EN,Dougherty DD

    更新日期:2013-02-01 00:00:00

  • Frontal Sinus Breach During Routine Frontal Craniotomy Significantly Increases Risk of Surgical Site Infection: 10-Year Retrospective Analysis.

    abstract:BACKGROUND:Frontotemporal craniotomies are commonly performed for a variety of neurosurgical pathologies. Infections related to craniotomies cause significant morbidity. We hypothesized that the risk of cranial surgical site infections (SSIs) may be increased in patients whose frontal sinuses are breached during cranio...


    pub_type: 杂志文章


    authors: Linzey JR,Wilson TJ,Sullivan SE,Thompson BG,Pandey AS

    更新日期:2017-09-01 00:00:00

  • Craniotomy and clipping of intracranial aneurysm in a stereoscopic virtual reality environment.

    abstract:OBJECTIVE:The release of results of International Subarachnoid Aneurysm Trial in 2003 caused a shift in the paradigm of management of ruptured intracranial aneurysms. The cases selected for microsurgical clipping nowadays are usually those patients with aneurysms that are not suitable for embolization, and are often co...


    pub_type: 杂志文章


    authors: Wong GK,Zhu CX,Ahuja AT,Poon WS

    更新日期:2007-09-01 00:00:00