Abstract:
:Glutamate antagonists are the most powerful neuroprotective drugs in laboratory studies of focal cerebral ischemia. Because the majority of clinical conditions in which focal brain ischemia occurs are associated with high intracranial pressure (ICP), we have used the rat acute subdural hematoma model to evaluate the effects of three glutamate N-methyl-D-aspartate antagonists, MK-801, CGS 19755 (SELFOTEL), D-CPP-ene, and mannitol, upon ICP and also upon the volume of ischemic brain damage. Only mannitol produced a significant reduction in ICP and improved cerebral perfusion pressure. The three glutamate antagonists did not significantly affect ICP or cerebral perfusion pressure, but they were associated with a significantly smaller zone of focal brain damage, when compared to the mannitol and saline groups. N-methyl-D-aspartate antagonists do not increase ICP or jeopardize cerebral perfusion pressure when administered under anesthesia with a controlled PaCO2 level. Further studies in humans are indicated.
journal_name
Neurosurgeryjournal_title
Neurosurgeryauthors
Kuroda Y,Fujisawa H,Strebel S,Graham DI,Bullock Rdoi
10.1227/00006123-199407000-00016subject
Has Abstractpub_date
1994-07-01 00:00:00pages
106-12issue
1eissn
0148-396Xissn
1524-4040journal_volume
35pub_type
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